Results 61 to 70 of about 4,698 (199)

The value of simultaneous determination of blood large neutral amino acids and tetrahydrobiopterin metabolites in the diagnosis of atypical hyperphenylalaninemia

Egyptian Liver Journal
Tetrahydrobiopterin deficiency in newborns with atypical hyperphenylalaninemia requires rapid and accurate diagnosis and the ability to distinguish it from the classical type to prevent early irreversible neurological damage.
Nadia Salama, Gamalte Elgedawy, Radwa Gamal, Osama Zaki, Ashraf Khalil, Manar Obada   +5 more
doaj   +1 more source

Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism

Pteridines, 1998
The influence of changes in catecholamine metabolism on tetrahydrobiopterin biosynthesis was investigated in cultured rat pheochromocytoma PC12 cells. The increase in the cellular dopamine content after treatment with the MAO-COMT inhibitor or dopamine ...
Kuzuya Hiroshi, Sakamoto Hideo, Fujita Ko   +2 more
doaj   +1 more source

Neurological aspects of biopterin metabolism. [PDF]

Archives of Disease in Childhood, 1986
Plasma total biopterin concentration was measured by bioassay in 59 infants with hyperphenylalaninaemia and in 50 children with developmental regression and or movement disorder with normal plasma phenylalanine concentrations. In infants with raised phenylalanine concentrations plasma biopterin concentrations were significantly raised in proportion to ...
I, Smith, R J, Leeming, N P, Cavanagh, K, Hyland   +3 more
openaire   +2 more sources

Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status

Journal of Biological Chemistry, 2009
Tetrahydrobiopterin (BH4) is a critical determinant of endothelial nitric-oxide synthase (eNOS) activity. In the absence of BH4, eNOS becomes “uncoupled” and generates superoxide rather than NO.
M. Crabtree, A. Tatham, Y. Al-Wakeel, N. Warrick, Ashley B. Hale, S. Cai, K. Channon, N. Alp   +7 more
semanticscholar   +1 more source

Comparative Genomics Insights Into the Evolutionary Disparities Between Nitroplast‐Evolved Ecotype UCYN‐A2 and Its Closest Relative UCYN‐A1

Ecology and Evolution, Volume 15, Issue 7, July 2025.
This paper conducted comparative genomic analyses among seven UCYN‐A strains in genome content, gene structure, and key metabolic protein genes. In general, our results demonstrated considerable disparities between UCYN‐A1 and UCYN‐A2, providing insights into the evolution of UCYN‐A and nitroplast.
Shiyun Han, Sijia Zhang, Wen Ge, Jianke Yang, Hui Peng, Jinming Gao, Mengsa Zhang, Yingying Xiao, Dongsheng Du, Xianzhao Kan   +9 more
wiley   +1 more source

Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children

Pteridines, 2012
Neopterin, as a non-conjugated pteridine, is synthesized from guanosine triphosphate and its production is upregulated upon the activation of cellular immune response.
Girgin Gözde, Baydar Terken, Fuchs Dietmar, Sahin Gönül, Özmert Elif, Yurdakök Kadriye   +5 more
doaj   +1 more source

Role of endothelial colony forming cells (ECFCs) Tetrahydrobiopterin (BH4) in determining ECFCs functionality in coronary artery disease (CAD) patients

Scientific Reports, 2022
Nitric oxide (NO . ) is critical for functionality of endothelial colony forming cells (ECFCs). Dimerization of endothelial nitric oxide synthase (eNOS) is must to produce NO . and tetrahydrobiopterin (BH4) plays a crucial role in stabilizing this state.
Atanu Sen, Archna Singh, Ambuj Roy, Sujata Mohanty, Nitish Naik, Mani Kalaivani, Lakshmy Ramakrishnan   +6 more
doaj   +1 more source

Partial Biopterin Deficiency Disturbs Postnatal Development of the Dopaminergic System in the Brain*

Journal of Biological Chemistry, 2010
Postnatal development of dopaminergic system is closely related to the development of psychomotor function. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of dopamine and requires tetrahydrobiopterin (BH4) as a cofactor.
Daigo Homma, C. Sumi-Ichinose, H. Tokuoka, K. Ikemoto, T. Nomura, Kazunao Kondo, S. Katoh, H. Ichinose   +7 more
semanticscholar   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Pteridine Pathway in Patients with Degenerative Diseases During Short Time Treatment with Low Dose of Meloxicam, as a Non-steroidal Anti-inflammatory Drug

Pteridines, 2008
The profiles of unconjugated pteridines such as neopterin and biopterin and of tryptophan metabolism change in many pathologic conditions such as rheumatoid arthritis, malignancies and autoimmune diseases and are related to the release of pro ...
Baydar Terken, Girgin Gozde, Fuchs Dietmar, Inanici Fatma, Sipahi Hande, Erol Ozlem, Sahin Gonul   +6 more
doaj   +1 more source