Results 41 to 50 of about 2,873 (175)
Pteridines, 2010 Biopterin as a stable metabolite is produced by oxidation of 5,6,7,8-tetrahydrobiopterin (BH4). It is known that many diseases may cause changes in BH4 concentration and/or dihydropteridine reductase (DHPR) enzyme activity. There is only a limited number
Girgin Gözde +7 more
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iMetaOmics, Volume 3, Issue 2, June 2026.Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal +4 more
wiley +1 more source
Evaluation of dihydropteridine reductase activities in patients with kidney failure
Pteridines, 2013 End-stage renal disease (ESRD) is the inability of the kidneys to remove waste products from the blood. The most important factors causing ESRD that require hemodialysis are diabetes and hypertension.
Palabıyık Şaziye Sezin +5 more
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Pteridines, 2017 Conjugated and unconjugated pteridines and their derivatives are important cofactors in cellular metabolism. Hence, the amount of unconjugated pteridines in biological fluids has been found to be modified as a result of several disorders. It is necessary
Espinosa-Mansilla Anunciación +1 more
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Skin Hyperpigmentation: An Under‐Recognized Dermatological Clue to Vitamin B12 Deficiency
Clinical Case Reports, Volume 14, Issue 5, May 2026.Hyperpigmentation over the dorsal aspect of both hands, prominently involving the knuckles. ABSTRACT Cutaneous hyperpigmentation, an overlooked manifestation, can be an early sign of vitamin B12 deficiency. This case highlights symmetric pigmentation on the dorsum of hands and palms in a long‐term vegetarian.
Mahesh Mathur +5 more
wiley +1 more source
Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins
Pteridines, 1995 Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L ...
Schallreuter-Wood Karin U., Wood John M.
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Journal of Chromatography OpenThis work presents the development of an analytical methodology based on the use of cyclodextrin-electrokinetic chromatography to achieve the enantiomeric separation of biopterin, a biologically relevant molecule that plays a significant role as a ...
S. Adámez-Rodríguez +2 more
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Egyptian Liver JournalTetrahydrobiopterin deficiency in newborns with atypical hyperphenylalaninemia requires rapid and accurate diagnosis and the ability to distinguish it from the classical type to prevent early irreversible neurological damage.
Nadia Salama +5 more
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Frontiers in PsychiatryDepressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská +7 more
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Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism
Pteridines, 1998 The influence of changes in catecholamine metabolism on tetrahydrobiopterin biosynthesis was investigated in cultured rat pheochromocytoma PC12 cells. The increase in the cellular dopamine content after treatment with the MAO-COMT inhibitor or dopamine ...
Kuzuya Hiroshi +2 more
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