Results 41 to 50 of about 2,891 (172)
Pteridines, 2010 Biopterin as a stable metabolite is produced by oxidation of 5,6,7,8-tetrahydrobiopterin (BH4). It is known that many diseases may cause changes in BH4 concentration and/or dihydropteridine reductase (DHPR) enzyme activity. There is only a limited number
Girgin Gözde +7 more
doaj +1 more source
Evaluation of dihydropteridine reductase activities in patients with kidney failure
Pteridines, 2013 End-stage renal disease (ESRD) is the inability of the kidneys to remove waste products from the blood. The most important factors causing ESRD that require hemodialysis are diabetes and hypertension.
Palabıyık Şaziye Sezin +5 more
doaj +1 more source
Liver‐ and Immune‐Enriched Molecular Signatures Associated With Mortality in Older Adults
Aging Cell, Volume 25, Issue 7, July 2026.Untargeted plasma proteomics and metabolomics identified molecular signatures associated with all‐cause mortality in older adults. A liver‐enriched proteomic profile was associated with mortality risk in the ILAS cohort and showed consistent associations in an independent validation cohort, supporting circulating proteomic profiles for mortality risk ...
Yi‐Long Huang +5 more
wiley +1 more source
Pteridines, 2017 Conjugated and unconjugated pteridines and their derivatives are important cofactors in cellular metabolism. Hence, the amount of unconjugated pteridines in biological fluids has been found to be modified as a result of several disorders. It is necessary
Espinosa-Mansilla Anunciación +1 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou +7 more
wiley +1 more source
Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins
Pteridines, 1995 Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L ...
Schallreuter-Wood Karin U., Wood John M.
doaj +1 more source
iMetaOmics, Volume 3, Issue 2, June 2026.Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal +4 more
wiley +1 more source
Journal of Chromatography OpenThis work presents the development of an analytical methodology based on the use of cyclodextrin-electrokinetic chromatography to achieve the enantiomeric separation of biopterin, a biologically relevant molecule that plays a significant role as a ...
S. Adámez-Rodríguez +2 more
doaj +1 more source
Egyptian Liver JournalTetrahydrobiopterin deficiency in newborns with atypical hyperphenylalaninemia requires rapid and accurate diagnosis and the ability to distinguish it from the classical type to prevent early irreversible neurological damage.
Nadia Salama +5 more
doaj +1 more source
Frontiers in PsychiatryDepressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská +7 more
doaj +1 more source