Results 61 to 70 of about 2,756 (173)

Pterin determination in cerebrospinal fluid: state of the art

Pteridines, 2017
The analysis of pterins in the cerebrospinal fluid (CSF) is mandatory for the etiologic diagnosis of inborn errors of dopamine and serotonin metabolism.
Guibal Pierre, Lo Aurélien, Maitre Philippe, Moussa Fathi   +3 more
doaj   +1 more source

Comparative Genomics Insights Into the Evolutionary Disparities Between Nitroplast‐Evolved Ecotype UCYN‐A2 and Its Closest Relative UCYN‐A1

Ecology and Evolution, Volume 15, Issue 7, July 2025.
This paper conducted comparative genomic analyses among seven UCYN‐A strains in genome content, gene structure, and key metabolic protein genes. In general, our results demonstrated considerable disparities between UCYN‐A1 and UCYN‐A2, providing insights into the evolution of UCYN‐A and nitroplast.
Shiyun Han, Sijia Zhang, Wen Ge, Jianke Yang, Hui Peng, Jinming Gao, Mengsa Zhang, Yingying Xiao, Dongsheng Du, Xianzhao Kan   +9 more
wiley   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Acrylamide induces spatiotemporal metabolic profiling disturbance via targeting taurine and hypotaurine metabolism during early zebrafish development

Food Frontiers, Volume 6, Issue 1, Page 282-299, January 2025.
This study provides in‐depth evidence on the metabolic regulation of zebrafish embryos with acrylamide exposure at different zebrafish developmental stages. The pattern of significantly changed metabolites revealed that acrylamide exposure has a detrimental effect on early heart development in zebrafish due to the inhibition of de novo synthesis of ...
Anli Wang, Jia Zeng, Xiaoran Song, Yingyu Huang, Jianxin Yao, Li Zhu, Yuchen Gao, Binjie Wang, Yuanzhao Wu, Zhongshi Xu, Ruonan Zheng, Yazhou Qin, Jiye Wang, Weixuan Yao, Xuzhi Wan, Haoyu Li, Pan Zhuang, Jingjing Jiao, Shulin Zhuang, Yu Zhang   +19 more
wiley   +1 more source

Late-stage systemic immune effectors in Plasmodium berghei ANKA infection: biopterin and oxidative stress

Pteridines, 2015
To investigate the involvement of systemic oxidative stress in the pathogenesis of murine cerebral malaria, mice were infected with the Plasmodium berghei (P. berghei) ANKA 6653 strain.
Dogruman-Al Funda, Engin Ayşe Başak, Bukan Neslihan, Evirgen-Bostanci Seda, Çeber Kemal   +4 more
doaj   +1 more source

Inhibitory Effects of Pteridines on the Cytochrome P-450 Enzyme System

Pteridines, 1997
The effects of 17 different pteridine derivatives on rat liver microsomal cytochrome P-450 catalyzed degradation of aminoantipyrin were studied.
Horejsi Renate, Daczki Jürgen, Mölller Reinhard, Öttl Karl, Vrecko Karoline, Reibnegger Gilbert   +5 more
doaj   +1 more source

Tetrahydrobiopterin Synthesis in Rat Cardiac Myocytes; An Event Required for Cytokine-induced NO Generation

Pteridines, 1998
Cardiac myocytes are known to express the high-capacity inducible isoform of nitric oxide (NO) synthase (iNOS). Since tetrahydrobiopterin (BH4) is an essential cofactor for NO formation, we investigated whether BH4 synthesis is required for cytokine ...
Hattori Yoshiyuki, Nakanishi Nobuo, Gross Steven S., Kasai Kikuo   +3 more
doaj   +1 more source

Oxidative Stress and Pteridines in Pediatric Asthma: Relationship to Exhaled Nitric Oxide

Pteridines, 2012
Fractional exhaled nitric oxide (FeNO) is a useful marker of airway inflammation in asthmatics. Nitric oxide synthase (NOS) requires tetrahydrobiopterin as a cofactor and produces superoxide during NO generation.
Takeda Taisuke, Hamazaki Takashi, Wakahara Ryohei, Fujioka Hiroki, Niihira Shizuhiro, Shintaku Haruo   +5 more
doaj   +1 more source

Concentrations of neopterin, biopterin, and cortisol associated with surgical castration of piglets with lidocaine

Czech Journal of Animal Science, 2015
The effect of surgical castration with local anesthesia using lidocaine on neopterin, biopterin, and cortisol blood plasma concentrations in piglets was studied.
P. Maršálek, M. Svoboda, J. Bernardy, V. Večerek   +3 more
doaj   +1 more source

The Influence of 2,4-Diamino-6-Hydroxypyrimidine and Food Restriction on Tetrahydrobiopterin Metabolism, Neurotransmitters and Behaviour in the Rat

Pteridines, 1991
Administration of 2,4-diamino-6-hydroxypyrimidine (DAHP) in the diet of rats reduced total biopterins in plasma, brain and liver. The levels of dihydropteridine reductase (DHPR) and the rate of biopterin biosynthesis were unaffected.
Cox J., Armstrong R. A., Blair J. A.
doaj   +1 more source