Results 31 to 40 of about 2,756 (173)
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Pteridines, 2010 Biopterin as a stable metabolite is produced by oxidation of 5,6,7,8-tetrahydrobiopterin (BH4). It is known that many diseases may cause changes in BH4 concentration and/or dihydropteridine reductase (DHPR) enzyme activity. There is only a limited number
Girgin Gözde +7 more
doaj +1 more source
iMetaOmics, EarlyView.Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal +4 more
wiley +1 more source
Evaluation of dihydropteridine reductase activities in patients with kidney failure
Pteridines, 2013 End-stage renal disease (ESRD) is the inability of the kidneys to remove waste products from the blood. The most important factors causing ESRD that require hemodialysis are diabetes and hypertension.
Palabıyık Şaziye Sezin +5 more
doaj +1 more source
British Journal of Haematology, EarlyView.Construction of the immune thrombocytopenia (ITP) chronicity prediction model was based on sex‐stratified multi‐omics analysis, identifying key sex‐specific predictors (intercellular adhesion molecule‐1 [ICAM‐1] and biopterin in males; actin, alpha 2, smooth muscle, aorta [ACTA‐2] and N6‐acetyl‐L‐lysine in females).
Yuanyuan Xue +10 more
wiley +1 more source
Pteridines, 2017 Conjugated and unconjugated pteridines and their derivatives are important cofactors in cellular metabolism. Hence, the amount of unconjugated pteridines in biological fluids has been found to be modified as a result of several disorders. It is necessary
Espinosa-Mansilla Anunciación +1 more
doaj +1 more source
Skin Hyperpigmentation: An Under‐Recognized Dermatological Clue to Vitamin B12 Deficiency
Clinical Case Reports, Volume 14, Issue 5, May 2026.Hyperpigmentation over the dorsal aspect of both hands, prominently involving the knuckles. ABSTRACT Cutaneous hyperpigmentation, an overlooked manifestation, can be an early sign of vitamin B12 deficiency. This case highlights symmetric pigmentation on the dorsum of hands and palms in a long‐term vegetarian.
Mahesh Mathur +5 more
wiley +1 more source
Plasma Nitrate and Pteridine Levels in Experimental Bacteremia in Baboons
Pteridines, 1995 Using a recently developed model of bacterially induced sepsis in baboons, we studied the time courses of pteridine and nitrate levels in plasma with regard to the dose of Escherichia coli. Eight animals were given a 2 h infusion of 2X 10" Colony Forming
Strohmaier Wolfgang +4 more
doaj +1 more source
Peripheral biopterin and neopterin in schizophrenia and depression
Psychiatry Research, 2021 Increasing evidence points to a causal involvement of inflammation in the pathogenesis of neuropsychiatric disorders, including major depressive disorder (MDD) and schizophrenia (SZ). Neopterin and biopterin may link peripheral immune system activation and central neurotransmitter alterations.
Klaus, Federica +7 more
openaire +4 more sources
Serum Biopterin as a Marker of Immune Activation in the Spontaneously Diabetic BB Rat
Pteridines, 1998 Tetrahydrobiopterin (BH4), is a pteridine product which is released by rodent macrophages and fibroblasts upon activation by cytokines. It has previously been reported as a potentially useful marker for monitoring immune activation during the prediabetic
Galloway Tamara +4 more
doaj +1 more source