Results 31 to 40 of about 2,891 (172)

Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection

Revista do Instituto de Medicina Tropical de São Paulo, 2021
Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease.
Caio Vinicius Botelho Brito, Érika Dayane Leal Rodrigues, Fernanda Monik Silva Martins, Lavinia Dias Tavares, André Luis de Sousa Nogueira Lima, Lucas Carvalho Ferreira, Carlos Junior Lopes Santana, João Augusto Gomes de Souza Monteiro de Brito, Lívia Medeiros Neves Casseb, José Antonio Picanço Diniz Junior   +9 more
doaj   +1 more source

Data‐Driven Insights into Hyperkinetic Disorders in Neurodevelopmental Syndromes and Epileptic Encephalopathies

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Childhood‐onset hyperkinetic movement disorders occur in a range of genetic conditions. Recently, there has been an increase in recognition of hyperkinetic movement disorders, mainly dystonia, chorea and dyskinesia, with monogenic conditions associated with neurodevelopmental delay (NDD) and also with developmental and epileptic ...
Hugo Morales‐Briceño, Shekeeb S. Mohammad, Rajeshwar Reddy Angiti, Velda Han, Michel Tchan, Russell C. Dale, Victor S.C. Fung   +6 more
wiley   +1 more source

Plasma Nitrate and Pteridine Levels in Experimental Bacteremia in Baboons

Pteridines, 1995
Using a recently developed model of bacterially induced sepsis in baboons, we studied the time courses of pteridine and nitrate levels in plasma with regard to the dose of Escherichia coli. Eight animals were given a 2 h infusion of 2X 10" Colony Forming
Strohmaier Wolfgang, Werner Ernst R., Redl Heinz, Wachter Helmut, Schlag Gunther   +4 more
doaj   +1 more source

Can the Nonheme Iron Oxygenase Thymine Hydroxylase Catalyze Three Successive Reaction Cycles on One Substrate?

ChemCatChem, Volume 18, Issue 18, 28 September 2026.
A computational study on the structure, dynamics and catalytic mechanism is reported on thymine hydroxylase that shows substrate locked inside the protein and enables three successive catalytic cycles for (1) thymine hydroxylation, 2) 5‐hydroxymethyluracil desaturation, and (3) 5‐formyluracil hydroxylation to form carboxylic acid products.
Jingyu Cao, Sam P. de Visser
wiley   +1 more source

Serum Biopterin as a Marker of Immune Activation in the Spontaneously Diabetic BB Rat

Pteridines, 1998
Tetrahydrobiopterin (BH4), is a pteridine product which is released by rodent macrophages and fibroblasts upon activation by cytokines. It has previously been reported as a potentially useful marker for monitoring immune activation during the prediabetic
Galloway Tamara, Braven Jim, Barley Jas, Rokos Hartmut, Wilkin Terence   +4 more
doaj   +1 more source

Biopterin in Parkinson's disease. [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1987
Tetrahydrobiopterin is an essential co-factor in the natural synthesis of dopamine. Oral tetrahydrobiopterin was given in small doses to four patients with early Parkinson's disease but had no discernible effect.
A P, Moore, P O, Behan, W, Jacobson, W L, Armarego   +3 more
openaire   +2 more sources

Exposure to Helicobacter pylori and Serum Kynurenine to Tryptophan Ratio in Patients with Gastric Cancer

Pteridines, 2010
In Helicobacter pylori seropositive individuals, the subsequent risk of non-cardia gastric cancer development is frequently attributed to the infection agent. Although the link between inflammation and gastric cancer is formally recognized, the molecular
Engin Ayse Basak, Karahalil Bensu, Karakaya Ali Esat, Engin Atilla   +3 more
doaj   +1 more source

Developmental and Phenotypic Outcomes in Mild Phenylalanine Hydroxylase Deficiency

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1814-1820, August 2026.
ABSTRACT Benign hyperphenylalaninemia (bHPA) is defined as elevated phenylalanine (Phe) levels remaining ≤ 360 μmol/L (6 mg/dL) and not requiring medical intervention. Individuals with bHPA may demonstrate a rise in their Phe levels > 360 μmol/L, effectively developing a mild PKU phenotype requiring therapy to prevent neurocognitive complications. This
Aaron Williams, Kristian Divin, Lindsay C. Burrage, William J. Craigen, Fernando Scaglia, Claudia Soler‐Alfonso, V. Reid Sutton, Kevin E. Glinton, Ronit Marom   +8 more
wiley   +1 more source

Pteridines and Lipid Metabolism

Pteridines, 1998
The effect of 9 different pteridines on fatty acid incorporation into phospholipids as well as on cholesterol and phospholipid content was compared in vitro using rat liver homogenate, Krebs-Ringer phosphate buffer containing 0.3 % albumin (pH=7.4 ...
Rudzite Vera, Jurika Edite, Baier-Bitterlich Gabriele, Widner Bernhard, Reibnegger Gilbert, Fuchs Dietmar   +5 more
doaj   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source