Results 11 to 20 of about 2,794 (172)

Integrated proteomic and metabolomic profiling reveals sex‐stratified biomarkers predicting chronicity in paediatric primary immune thrombocytopenia [PDF]

British Journal of Haematology, Volume 208, Issue 6, Page 1954-1964, June 2026.
Construction of the immune thrombocytopenia (ITP) chronicity prediction model was based on sex‐stratified multi‐omics analysis, identifying key sex‐specific predictors (intercellular adhesion molecule‐1 [ICAM‐1] and biopterin in males; actin, alpha 2, smooth muscle, aorta [ACTA‐2] and N6‐acetyl‐L‐lysine in females).
Yuanyuan Xue, Rongrong Zhang, Dongmei Liang, Yupeng Xu, Zhaofang Tian, Xiaohong Dai, Wei Xu, Qingqing Cao, Haiyan Zhu, Yun Wang, Yufang Yuan   +10 more
wiley   +2 more sources

Age‐Dependent Variation in Blood Biopterin Peaks Following Oral Tetrahydrobiopterin Administration in Phenylketonuria [PDF]

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT The correct diagnosis of tetrahydrobiopterin (BH4, sapropterin dihydrochloride)‐responsive phenylketonuria (PKU) and treatment with BH4 are important for prognosis and quality of life. We examined whether age affects biopterin bioavailability following oral BH4 administration in PKU and whether this influences BH4 responsiveness.
Kana Kitayama, Tomoko Sakaguchi, Noriko Nakano, Daijiro Kabata, Haruo Shintaku, Takashi Hamazaki   +5 more
wiley   +2 more sources

A Novel Multimodal LC–MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF [PDF]

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Stine Christ, Julia Rossmann, Sylvia Richter, Sven Garbade, Glynis Klinke, Nenad Blau, Georg Friedrich Hoffmann, Jürgen Günther Okun, Thomas Opladen   +8 more
wiley   +2 more sources

A systematic review and meta-analysis of pteridines in mild cognitive impairment and Alzheimer’s disease [PDF]

BMC Geriatrics
Background Alterations in specific pteridine metabolites, particularly neopterin, biopterin, and tetrahydrobiopterin have been reported in mild cognitive impairment, Alzheimer’s disease, and other types of dementia.
Arduino A. Mangoni, Angelo Zinellu
doaj   +2 more sources

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes. [PDF]

PLoS Neglected Tropical Diseases
Mammalian cells synthesise tetrahydrobiopterin de novo, an essential cofactor for hydroxylation of aromatic amino acids, cleavage of ether lipids and the synthesis of nitric oxide.
Han B Ong, Susan Wyllie, Alan H Fairlamb
doaj   +2 more sources

Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth [PDF]

Communications Medicine
Background Exposure to tobacco smoke during pregnancy is an established risk factor for early birth including early term birth (ETB) and preterm birth (PTB). However, the underlying molecular mechanisms are minimally understood.
Paula-Dene C. Nesbeth, Xiajie Lyu, Anne L. Dunlop, Youran Tan, Dana Boyd Barr, Volha Yakimavets, Parinya Panuwet, Mengyuan Ren, Stephanie M. Eick, Blake R. Rushing, Susan L. McRitchie, Susan Sumner, P. Barry Ryan, Elizabeth J. Corwin, Dean P. Jones, Donghai Liang   +15 more
doaj   +2 more sources

Enhanced Monacolin K Production in Monascus purpureus Via Mutagenesis and Nitrogen Source Optimization [PDF]

Journal of Basic Microbiology, Volume 66, Issue 2, February 2026.
ABSTRACT Monascus fungi are valued for their production of Monacolin K (MK), a bioactive compound with recognized lipid‐lowering and multifunctional properties. To enhance MK yield in solid‐state fermentation, this study combined atmospheric and room‐temperature plasma (ARTP) mutagenesis with L‐arginine supplementation.
Chen Yang, Yang Yajing, Hong Housheng
wiley   +2 more sources

An Enzyme Immunoassay for Neopterin and Biopterin Using a Microtitre Plate Linked with N2-(3-Aminopropyl) Derivatives of Pteridines

Pteridines, 1990
A novel and sensitive enzyme immunoassay for neopterin and biopterin using a microtitre plate has been developed. The antiserum against neopterin or biopterin was incubated with samples prepared from human urine or rat tissues, and was placed in a well ...
Sugimoto Takashi, Ogiwara Shoji, Kiuchi Kazutoshi, Nagatsu Toshiharu, Sakai Masao, Nagatsu Ikuko, Fujita Keisuke   +6 more
doaj   +1 more source

Usefulness of serum biopterin as a predictive biomarker for childhood asthma control: A prospective cohort study

Allergology International, 2019
Background: Pteridines are metabolites of tetrahydrobiopterin, which serves as co-enzyme of nitric oxide synthase. We sought to investigate the usefulness of pteridines as biomarkers for childhood asthma control.
Saki Kasuga, Daijiro Kabata, Tomoko Sakaguchi, Satoshi Kudoh, Satsuki Nishigaki, Yusuke Higa, Shiori Fujikawa, Hiroko Fujitani, Ayumi Shintani, Takashi Hamazaki, Haruo Shintaku   +10 more
doaj   +1 more source

Plasma Levels of Neopterin and Biopterin in the Umbilical Vessels and the Maternal Vein

Pteridines, 2003
Tetrahydrobiopterin (BH4) is a highly bioactive pterin required for nitric oxide synthase and monooxygenases of aromatic amino acids, and is involved in the synthesis of nitric oxide, catecholamines and Serotonin.
Iwanaga Naoko, Yamamasu Seiichi, Tachibana Daisuke, Nishio Junko, Nakai Yuichiro, Shintaku Haruo, Imanaka Motoharu, Yamano Tsunekazu, Ishiko Osamu   +8 more
doaj   +1 more source