Results 11 to 20 of about 2,891 (172)

An Overview of Pterin Analysis in Biological Samples: From Occurrence and Properties to Sample Pretreatment Combined With Hyphenated Separation Techniques. [PDF]

J Sep Sci
ABSTRACT Pterins are a structurally diverse group of biologically active compounds within the pteridine family, with key roles in pigmentation, redox metabolism, light sensing, and cellular signaling across a wide range of organisms. Their quantification in biological samples is analytically demanding due to their high polarity, chemical instability ...
Brejcha J, Bosakova Z.
europepmc   +2 more sources

Integrated proteomic and metabolomic profiling reveals sex-stratified biomarkers predicting chronicity in paediatric primary immune thrombocytopenia. [PDF]

Br J Haematol
Construction of the immune thrombocytopenia (ITP) chronicity prediction model was based on sex‐stratified multi‐omics analysis, identifying key sex‐specific predictors (intercellular adhesion molecule‐1 [ICAM‐1] and biopterin in males; actin, alpha 2, smooth muscle, aorta [ACTA‐2] and N6‐acetyl‐L‐lysine in females).
Xue Y, Zhang R, Liang D, Xu Y, Tian Z, Dai X, Xu W, Cao Q, Zhu H, Wang Y, Yuan Y.   +10 more
europepmc   +2 more sources

Age-Dependent Variation in Blood Biopterin Peaks Following Oral Tetrahydrobiopterin Administration in Phenylketonuria. [PDF]

J Inherit Metab Dis
ABSTRACT The correct diagnosis of tetrahydrobiopterin (BH4, sapropterin dihydrochloride)‐responsive phenylketonuria (PKU) and treatment with BH4 are important for prognosis and quality of life. We examined whether age affects biopterin bioavailability following oral BH4 administration in PKU and whether this influences BH4 responsiveness.
Kitayama K, Sakaguchi T, Nakano N, Kabata D, Shintaku H, Hamazaki T.   +5 more
europepmc   +2 more sources

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Papaccio F, Scano S, Bellei B.
europepmc   +2 more sources

A Novel Multimodal LC-MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF. [PDF]

J Inherit Metab Dis
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Christ S, Rossmann J, Richter S, Garbade S, Klinke G, Blau N, Hoffmann GF, Okun JG, Opladen T.   +8 more
europepmc   +2 more sources

eQTL Meta-Analysis Reveals Conserved and Population-Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato. [PDF]

Adv Sci (Weinh)
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Zhao J, Wang X, Zhang J, McQuinn R, Lee JM, Gonda I, Feder A, Xu Y, Wang B, Yu Q, Tieman DM, Huang S, Klee H, Giovannoni JJ, Fei Z.   +14 more
europepmc   +2 more sources

Pteridines CV

Pteridines, 1995
Treatment of L-biopterin (I) with N,N-dimethyformamide dimethyl- (or diethyl)acetal and then with acetic anhydride in pyridine gave 1',2'-di-O-acetyl-N'-(N,N-dimethylaminomethylene)-L-biopterin (4), which was converted by the Mitsunobu reaction into 3 ...
Hanaya Tadashi, Torigoe Kiyoshi, Soranaka Kazuyuki, Yamamoto Horoshi, Qizhengt Yao, Pfleiderer Wolfgang   +5 more
doaj   +1 more source

Correlation between Neopterin, Biopterin and Nitrite/Nitrate in Cerebrospinal Fluid in Child Patients with Neurological Diseases

Pteridines, 2003
Cerebrospinal fluid (CSF) neopterin been previously reported in various diseases. In this study CSF neopterin, biopterin, and nitrite/nitrate (NOx) Contents were measured and the correlation between them in child patients with various kinds of ...
Kawakami Yasuhiko, Sakamoto Mayuko, Shimada Ken-ichi, Noguchi Eiji, Kuwabara Kentaro, Fukui-Kobayashi Tomoko, Shirota Kazuhiko, Ogawa Ko-ichi, Fujita Takehisa, Fujino Osamu, Kojima Shuji, Fukunaga Yoshitaka   +11 more
doaj   +1 more source

Influence of an Aromatic Amino Acid Decarboxylase Inhibitor on GTP Cyclohydrolase I Activity in the Rat Brain

Pteridines, 1997
Based on the hypothesis that catecholamine decreases may cause increases in biopterin, we measured the GTP cyclohydrolase I(GTPCH-I) activity and biopterin content in the cerebral cortex, midbrain/diencephalon, cerebeilum, pons/medulla oblongata ...
Sakamoto Hideo, Fujita Ko, Kuzuya Hiroshi   +2 more
doaj   +1 more source

An Enzyme Immunoassay for Neopterin and Biopterin Using a Microtitre Plate Linked with N2-(3-Aminopropyl) Derivatives of Pteridines

Pteridines, 1990
A novel and sensitive enzyme immunoassay for neopterin and biopterin using a microtitre plate has been developed. The antiserum against neopterin or biopterin was incubated with samples prepared from human urine or rat tissues, and was placed in a well ...
Sugimoto Takashi, Ogiwara Shoji, Kiuchi Kazutoshi, Nagatsu Toshiharu, Sakai Masao, Nagatsu Ikuko, Fujita Keisuke   +6 more
doaj   +1 more source