Results 11 to 20 of about 2,756 (173)

Age-Dependent Variation in Blood Biopterin Peaks Following Oral Tetrahydrobiopterin Administration in Phenylketonuria. [PDF]

J Inherit Metab Dis
ABSTRACT The correct diagnosis of tetrahydrobiopterin (BH4, sapropterin dihydrochloride)‐responsive phenylketonuria (PKU) and treatment with BH4 are important for prognosis and quality of life. We examined whether age affects biopterin bioavailability following oral BH4 administration in PKU and whether this influences BH4 responsiveness.
Kitayama K, Sakaguchi T, Nakano N, Kabata D, Shintaku H, Hamazaki T.   +5 more
europepmc   +2 more sources

A Novel Multimodal LC-MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF. [PDF]

J Inherit Metab Dis
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Christ S, Rossmann J, Richter S, Garbade S, Klinke G, Blau N, Hoffmann GF, Okun JG, Opladen T.   +8 more
europepmc   +2 more sources

Enhanced Monacolin K Production in Monascus purpureus Via Mutagenesis and Nitrogen Source Optimization. [PDF]

J Basic Microbiol
ABSTRACT Monascus fungi are valued for their production of Monacolin K (MK), a bioactive compound with recognized lipid‐lowering and multifunctional properties. To enhance MK yield in solid‐state fermentation, this study combined atmospheric and room‐temperature plasma (ARTP) mutagenesis with L‐arginine supplementation.
Yang C, Yajing Y, Housheng H.
europepmc   +2 more sources

Pteridines CV

Pteridines, 1995
Treatment of L-biopterin (I) with N,N-dimethyformamide dimethyl- (or diethyl)acetal and then with acetic anhydride in pyridine gave 1',2'-di-O-acetyl-N'-(N,N-dimethylaminomethylene)-L-biopterin (4), which was converted by the Mitsunobu reaction into 3 ...
Hanaya Tadashi, Torigoe Kiyoshi, Soranaka Kazuyuki, Yamamoto Horoshi, Qizhengt Yao, Pfleiderer Wolfgang   +5 more
doaj   +1 more source

Correlation between Neopterin, Biopterin and Nitrite/Nitrate in Cerebrospinal Fluid in Child Patients with Neurological Diseases

Pteridines, 2003
Cerebrospinal fluid (CSF) neopterin been previously reported in various diseases. In this study CSF neopterin, biopterin, and nitrite/nitrate (NOx) Contents were measured and the correlation between them in child patients with various kinds of ...
Kawakami Yasuhiko, Sakamoto Mayuko, Shimada Ken-ichi, Noguchi Eiji, Kuwabara Kentaro, Fukui-Kobayashi Tomoko, Shirota Kazuhiko, Ogawa Ko-ichi, Fujita Takehisa, Fujino Osamu, Kojima Shuji, Fukunaga Yoshitaka   +11 more
doaj   +1 more source

Influence of an Aromatic Amino Acid Decarboxylase Inhibitor on GTP Cyclohydrolase I Activity in the Rat Brain

Pteridines, 1997
Based on the hypothesis that catecholamine decreases may cause increases in biopterin, we measured the GTP cyclohydrolase I(GTPCH-I) activity and biopterin content in the cerebral cortex, midbrain/diencephalon, cerebeilum, pons/medulla oblongata ...
Sakamoto Hideo, Fujita Ko, Kuzuya Hiroshi   +2 more
doaj   +1 more source

An Enzyme Immunoassay for Neopterin and Biopterin Using a Microtitre Plate Linked with N2-(3-Aminopropyl) Derivatives of Pteridines

Pteridines, 1990
A novel and sensitive enzyme immunoassay for neopterin and biopterin using a microtitre plate has been developed. The antiserum against neopterin or biopterin was incubated with samples prepared from human urine or rat tissues, and was placed in a well ...
Sugimoto Takashi, Ogiwara Shoji, Kiuchi Kazutoshi, Nagatsu Toshiharu, Sakai Masao, Nagatsu Ikuko, Fujita Keisuke   +6 more
doaj   +1 more source

Usefulness of serum biopterin as a predictive biomarker for childhood asthma control: A prospective cohort study

Allergology International, 2019
Background: Pteridines are metabolites of tetrahydrobiopterin, which serves as co-enzyme of nitric oxide synthase. We sought to investigate the usefulness of pteridines as biomarkers for childhood asthma control.
Saki Kasuga, Daijiro Kabata, Tomoko Sakaguchi, Satoshi Kudoh, Satsuki Nishigaki, Yusuke Higa, Shiori Fujikawa, Hiroko Fujitani, Ayumi Shintani, Takashi Hamazaki, Haruo Shintaku   +10 more
doaj   +1 more source

Plasma Levels of Neopterin and Biopterin in the Umbilical Vessels and the Maternal Vein

Pteridines, 2003
Tetrahydrobiopterin (BH4) is a highly bioactive pterin required for nitric oxide synthase and monooxygenases of aromatic amino acids, and is involved in the synthesis of nitric oxide, catecholamines and Serotonin.
Iwanaga Naoko, Yamamasu Seiichi, Tachibana Daisuke, Nishio Junko, Nakai Yuichiro, Shintaku Haruo, Imanaka Motoharu, Yamano Tsunekazu, Ishiko Osamu   +8 more
doaj   +1 more source

Disorders of biopterin metabolism [PDF]

Journal of Inherited Metabolic Disease, 2009
SummaryDefects in the metabolism or regeneration of tetrahydrobiopterin (BH4) were initially discovered in patients with hyperphenylalaninaemia who had progressive neurological deterioration despite optimal metabolic control (malignant hyperphenylalaninaemia).
openaire   +2 more sources