Results 1 to 10 of about 2,873 (175)

Tetrahydro-6-biopterin is associated with tetrahydro-7-biopterin in primary murine mast cells [PDF]

FEBS Letters, 1992
Murine bone marrow‐derived mast cells proliferate in response to interleukin 3. In addition to 6‐biopterin, 7‐biopterin was identified in these cells by HPLC analysis of iodine oxidized extracts and by alkaline permanganate oxidation to the 6‐ and 7‐carboxylic acids. 7‐Biopterin comprised 31.9 (± 7.7)% of the total biopterin.
L Hültner, I Ziegler
exaly   +3 more sources

The Levels of Neopterin, Biopterin and the Neopterin/Biopterin Ratio in Urine from Control Subjects and Patients with Alzheimer's Disease and Down's Syndrome

Pteridines, 1995
The levels of neopterin, biopterin and the neopterin/biopterin ratio (NIB) were measured in urine samples taken from normal young and elderly control subjects, exceptionally healthy elderly control subjects classified according to the 'Senieur' protocol ...
R A Armstrong, J A Blair
exaly   +2 more sources

A systematic review and meta-analysis of pteridines in mild cognitive impairment and Alzheimer’s disease [PDF]

BMC Geriatrics
Background Alterations in specific pteridine metabolites, particularly neopterin, biopterin, and tetrahydrobiopterin have been reported in mild cognitive impairment, Alzheimer’s disease, and other types of dementia.
Arduino A. Mangoni, Angelo Zinellu
doaj   +2 more sources

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes. [PDF]

PLoS Neglected Tropical Diseases
Mammalian cells synthesise tetrahydrobiopterin de novo, an essential cofactor for hydroxylation of aromatic amino acids, cleavage of ether lipids and the synthesis of nitric oxide.
Han B Ong, Susan Wyllie, Alan H Fairlamb
doaj   +2 more sources

Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth [PDF]

Communications Medicine
Background Exposure to tobacco smoke during pregnancy is an established risk factor for early birth including early term birth (ETB) and preterm birth (PTB). However, the underlying molecular mechanisms are minimally understood.
Paula-Dene C. Nesbeth, Xiajie Lyu, Anne L. Dunlop, Youran Tan, Dana Boyd Barr, Volha Yakimavets, Parinya Panuwet, Mengyuan Ren, Stephanie M. Eick, Blake R. Rushing, Susan L. McRitchie, Susan Sumner, P. Barry Ryan, Elizabeth J. Corwin, Dean P. Jones, Donghai Liang   +15 more
doaj   +2 more sources

Dystonia and Biopterin Deficiency

Pediatric Neurology Briefs, 1988
Five patients with childhood dystonia associated with reduced CSF biopterin, responsive to levodopa, and characterized by diurnal and exertional variation are reported from the Developmental and Metabolic Neurology Branch, National Institute of ...
J Gordon Millichap
doaj   +4 more sources

Integrated proteomic and metabolomic profiling reveals sex-stratified biomarkers predicting chronicity in paediatric primary immune thrombocytopenia. [PDF]

Br J Haematol
Construction of the immune thrombocytopenia (ITP) chronicity prediction model was based on sex‐stratified multi‐omics analysis, identifying key sex‐specific predictors (intercellular adhesion molecule‐1 [ICAM‐1] and biopterin in males; actin, alpha 2, smooth muscle, aorta [ACTA‐2] and N6‐acetyl‐L‐lysine in females).
Xue Y, Zhang R, Liang D, Xu Y, Tian Z, Dai X, Xu W, Cao Q, Zhu H, Wang Y, Yuan Y.   +10 more
europepmc   +2 more sources

Age-Dependent Variation in Blood Biopterin Peaks Following Oral Tetrahydrobiopterin Administration in Phenylketonuria. [PDF]

J Inherit Metab Dis
ABSTRACT The correct diagnosis of tetrahydrobiopterin (BH4, sapropterin dihydrochloride)‐responsive phenylketonuria (PKU) and treatment with BH4 are important for prognosis and quality of life. We examined whether age affects biopterin bioavailability following oral BH4 administration in PKU and whether this influences BH4 responsiveness.
Kitayama K, Sakaguchi T, Nakano N, Kabata D, Shintaku H, Hamazaki T.   +5 more
europepmc   +2 more sources

A Novel Multimodal LC-MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF. [PDF]

J Inherit Metab Dis
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Christ S, Rossmann J, Richter S, Garbade S, Klinke G, Blau N, Hoffmann GF, Okun JG, Opladen T.   +8 more
europepmc   +2 more sources

The High Concentration of Biopterin In Breast Milk and It's Absorption During the Neonatal Period

Pteridines, 1995
Breast milk has been found to contain high levels of biopterin compounds, whose physiological roles have attracted attention through newly discovered functions, particularly. as a cofactor for biosynthesis of nitric oxide.
Iizuka Tadashi, Ohishi Koh, Suzuki Hime, Hatanaka Yoshihumi, Kamisako Hitomi, Minatogawa Yosuke, Uemura Sigeru, Koike Michio   +7 more
doaj   +1 more source