Results 71 to 80 of about 6,578 (240)

Evaluation of dihydropteridine reductase activities in patients with kidney failure

Pteridines, 2013
End-stage renal disease (ESRD) is the inability of the kidneys to remove waste products from the blood. The most important factors causing ESRD that require hemodialysis are diabetes and hypertension.
Palabıyık Şaziye Sezin, Aşçı Ali, Girgin Gözde, Şahin Gönül, Çetinkaya Ramazan, Baydar Terken   +5 more
doaj   +1 more source

Comparative Genomics Insights Into the Evolutionary Disparities Between Nitroplast‐Evolved Ecotype UCYN‐A2 and Its Closest Relative UCYN‐A1

Ecology and Evolution, Volume 15, Issue 7, July 2025.
This paper conducted comparative genomic analyses among seven UCYN‐A strains in genome content, gene structure, and key metabolic protein genes. In general, our results demonstrated considerable disparities between UCYN‐A1 and UCYN‐A2, providing insights into the evolution of UCYN‐A and nitroplast.
Shiyun Han, Sijia Zhang, Wen Ge, Jianke Yang, Hui Peng, Jinming Gao, Mengsa Zhang, Yingying Xiao, Dongsheng Du, Xianzhao Kan   +9 more
wiley   +1 more source

Pteridine determination in human serum with special emphasis on HPLC methods with fluorimetric detection

Pteridines, 2017
Conjugated and unconjugated pteridines and their derivatives are important cofactors in cellular metabolism. Hence, the amount of unconjugated pteridines in biological fluids has been found to be modified as a result of several disorders. It is necessary
Espinosa-Mansilla Anunciación, Durán-Merás Isabel   +1 more
doaj   +1 more source

First Synthesis of Biopterin α-D-Glucoside [PDF]

, 2009
A novel glycosyl donor, 4,6-di-O-acetyl-2,3-di-O-(4-methoxy-benzyl)-α-D-glucopyranosy bromide (15) was efficiently prepared from D-glucose in 8 steps.
Baba, Hiroki, Hanaya, Tadashi, Yamamoto, Hiroshi   +2 more
core   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Acrylamide induces spatiotemporal metabolic profiling disturbance via targeting taurine and hypotaurine metabolism during early zebrafish development

Food Frontiers, Volume 6, Issue 1, Page 282-299, January 2025.
This study provides in‐depth evidence on the metabolic regulation of zebrafish embryos with acrylamide exposure at different zebrafish developmental stages. The pattern of significantly changed metabolites revealed that acrylamide exposure has a detrimental effect on early heart development in zebrafish due to the inhibition of de novo synthesis of ...
Anli Wang, Jia Zeng, Xiaoran Song, Yingyu Huang, Jianxin Yao, Li Zhu, Yuchen Gao, Binjie Wang, Yuanzhao Wu, Zhongshi Xu, Ruonan Zheng, Yazhou Qin, Jiye Wang, Weixuan Yao, Xuzhi Wan, Haoyu Li, Pan Zhuang, Jingjing Jiao, Shulin Zhuang, Yu Zhang   +19 more
wiley   +1 more source

Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins

Pteridines, 1995
Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L ...
Schallreuter-Wood Karin U., Wood John M.
doaj   +1 more source

Synthesis of 6-Hydroxymethylpterin α- and β-D-Glucosides [PDF]

, 2010
The key precursor, N(2)-(N,N-dimethylaminomethylene)-6-hydroxymethyl-3-[2-(4-nitrophenyl)ethyl]pterin (11) was efficiently prepared from 2,5,6-triamino-4-hydroxypyrimidine (8) in 5 steps.
Baba, Hiroki, Ejiri, Kazumasa, Hanaya, Tadashi, Yamamoto, Hiroshi   +3 more
core   +1 more source

Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism

Pteridines, 1998
The influence of changes in catecholamine metabolism on tetrahydrobiopterin biosynthesis was investigated in cultured rat pheochromocytoma PC12 cells. The increase in the cellular dopamine content after treatment with the MAO-COMT inhibitor or dopamine ...
Kuzuya Hiroshi, Sakamoto Hideo, Fujita Ko   +2 more
doaj   +1 more source

Neurological aspects of biopterin metabolism. [PDF]

Archives of Disease in Childhood, 1986
Plasma total biopterin concentration was measured by bioassay in 59 infants with hyperphenylalaninaemia and in 50 children with developmental regression and or movement disorder with normal plasma phenylalanine concentrations. In infants with raised phenylalanine concentrations plasma biopterin concentrations were significantly raised in proportion to ...
I, Smith, R J, Leeming, N P, Cavanagh, K, Hyland   +3 more
openaire   +2 more sources