Results 71 to 80 of about 4,698 (199)

Acrylamide induces spatiotemporal metabolic profiling disturbance via targeting taurine and hypotaurine metabolism during early zebrafish development

Food Frontiers, Volume 6, Issue 1, Page 282-299, January 2025.
This study provides in‐depth evidence on the metabolic regulation of zebrafish embryos with acrylamide exposure at different zebrafish developmental stages. The pattern of significantly changed metabolites revealed that acrylamide exposure has a detrimental effect on early heart development in zebrafish due to the inhibition of de novo synthesis of ...
Anli Wang, Jia Zeng, Xiaoran Song, Yingyu Huang, Jianxin Yao, Li Zhu, Yuchen Gao, Binjie Wang, Yuanzhao Wu, Zhongshi Xu, Ruonan Zheng, Yazhou Qin, Jiye Wang, Weixuan Yao, Xuzhi Wan, Haoyu Li, Pan Zhuang, Jingjing Jiao, Shulin Zhuang, Yu Zhang   +19 more
wiley   +1 more source

Immune Stimulation of Interferon-Gamma- and Biopterin Synthesis with Endotoxin in Animal-Experimental Peritonitis

Pteridines, 1993
As a result to a microhial stimulus different defence systems are activated. Bacterial lipopolysaccharids (endotoxins) can lead to activation of the immune system in which phagocytic cells like macrophages.
Kullich W., Weissenhofer W., Hunsicker A., Rokos H.   +3 more
doaj   +1 more source

Pterins as Sensors of Response to the Application of Fe3+-Dextran in Piglets

Sensors, 2010
The aim of the presented study was to assess the effect of a single administration of Fe3+-dextran on immune cell counts and pterin biomolecule production as novel sensors of the piglets' immune system activation, and to determine concentrations of ...
Klara Breinekova, Martin Svoboda, Miriam Smutna   +2 more
doaj   +1 more source

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

FEBS Letters, 1991
Brain nitric oxide synthase is a Ca2+/calmodulin‐regulated enzyme which converts L‐arginine into NO. Enzymatic activity of this enzyme essentially depends on NADPH and is stimulated by tetrahydrobiopterin (H4biopterin). We found that purified NO synthase
B. Mayer, Mathias John, Burghard Heinzel, E. Werner, H. Wachter, G. Schultz, E. Böhme   +6 more
semanticscholar   +1 more source

Degeneration of Rat Retina is Paralleled by an Imbalance of the Redox Mechanism of Pteridines

Pteridines, 1996
The RCS rat suffers from a genetic degeneration of retinal cell We have examined the pattern of oxidized and reduced monapterin and biopterin in retinas from RCS retinas and controls.
Cremer-Bartels Gertrud
doaj   +1 more source

Consensus Integration of Multiomics Data With Machine Learning Algorithms Reveals Heterogeneous Molecular Subtypes and Enables Personalized Treatment Strategies for Hepatocellular Carcinoma

Human Mutation, Volume 2025, Issue 1, 2025.
Background Cancers are characterized by high heterogeneity. This study seeks to identify the factors driving hepatocellular carcinoma (HCC) heterogeneity to aid in prognostic stratification and inform personalized treatment approaches. Methods We used a computational pipeline to integrate multiomics data from HCC patients, applying 10 clustering ...
Zhipeng Jin, Kun Fang, Xue Zhang, Mengying Song, Hong Jiang, Yefu Liu, Sujit Nair   +6 more
wiley   +1 more source

Pterin determination in cerebrospinal fluid: state of the art

Pteridines, 2017
The analysis of pterins in the cerebrospinal fluid (CSF) is mandatory for the etiologic diagnosis of inborn errors of dopamine and serotonin metabolism.
Guibal Pierre, Lo Aurélien, Maitre Philippe, Moussa Fathi   +3 more
doaj   +1 more source

Attenuating susceptibility to ascites in cold‐stressed broiler chickens fed canola meal‐based diets by supplementing arginine or guanidinoacetic acid, either alone or in combination with phenylalanine

Veterinary Medicine and Science, Volume 10, Issue 6, November 2024.
For ARG subscript: Decreased ascites mortality by increased plasma nitric oxide (NO), decreased RV:TV ratio and improved blood oxygen levels. For PHE subscript: Improved feed conversion ratio and decreased ascites susceptibility when combined with ARG or GAA.
Negin Delfani, Mohsen Daneshyar, Parviz Farhoomand, Sina Payvastegan, Younes Ali Alijoo, Gholamreza Najafi   +5 more
wiley   +1 more source

Comparative analysis of gene and disease selection in genomic newborn screening studies

Journal of Inherited Metabolic Disease, Volume 47, Issue 5, Page 945-970, September 2024.
Abstract Genomic newborn screening (gNBS) is on the horizon given the decreasing costs of sequencing and the advanced understanding of the impact of genetic variants on health and diseases. Key to ongoing gNBS pilot studies is the selection of target diseases and associated genes to be included.
Isabel R. Betzler, Maja Hempel, Ulrike Mütze, Stefan Kölker, Eva Winkler, Nicola Dikow, Sven F. Garbade, Christian P. Schaaf, Heiko Brennenstuhl   +8 more
wiley   +1 more source

Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high‐salt diet

Acta Physiologica, Volume 240, Issue 9, September 2024.
Abstract Aim We aimed to test the hypothesis that a high‐salt diet (HS) impairs NO signaling in kidney microvascular endothelial cells through a histone deacetylase 1 (HDAC1)‐dependent mechanism. Methods Male Sprague Dawley rats were fed normal salt diet (NS; 0.49% NaCl) or HS (4% NaCl) for 2 weeks. NO signaling was assessed by measuring L‐NAME induced
Luke S. Dunaway, Anthony K. Cook, Cailin E. Kellum, Claudia Edell, Davide Botta, Patrick A. Molina, Randee S. Sedaka, Livius V. d'Uscio, Zvonimir S. Katusic, David M. Pollock, Edward W. Inscho, Jennifer S. Pollock   +11 more
wiley   +1 more source