Results 81 to 90 of about 6,578 (240)

Consensus Integration of Multiomics Data With Machine Learning Algorithms Reveals Heterogeneous Molecular Subtypes and Enables Personalized Treatment Strategies for Hepatocellular Carcinoma

Human Mutation, Volume 2025, Issue 1, 2025.
Background Cancers are characterized by high heterogeneity. This study seeks to identify the factors driving hepatocellular carcinoma (HCC) heterogeneity to aid in prognostic stratification and inform personalized treatment approaches. Methods We used a computational pipeline to integrate multiomics data from HCC patients, applying 10 clustering ...
Zhipeng Jin, Kun Fang, Xue Zhang, Mengying Song, Hong Jiang, Yefu Liu, Sujit Nair   +6 more
wiley   +1 more source

The value of simultaneous determination of blood large neutral amino acids and tetrahydrobiopterin metabolites in the diagnosis of atypical hyperphenylalaninemia

Egyptian Liver Journal
Tetrahydrobiopterin deficiency in newborns with atypical hyperphenylalaninemia requires rapid and accurate diagnosis and the ability to distinguish it from the classical type to prevent early irreversible neurological damage.
Nadia Salama, Gamalte Elgedawy, Radwa Gamal, Osama Zaki, Ashraf Khalil, Manar Obada   +5 more
doaj   +1 more source

Pteridine Pathway in Patients with Degenerative Diseases During Short Time Treatment with Low Dose of Meloxicam, as a Non-steroidal Anti-inflammatory Drug

Pteridines, 2008
The profiles of unconjugated pteridines such as neopterin and biopterin and of tryptophan metabolism change in many pathologic conditions such as rheumatoid arthritis, malignancies and autoimmune diseases and are related to the release of pro ...
Baydar Terken, Girgin Gozde, Fuchs Dietmar, Inanici Fatma, Sipahi Hande, Erol Ozlem, Sahin Gonul   +6 more
doaj   +1 more source

Role of endothelial colony forming cells (ECFCs) Tetrahydrobiopterin (BH4) in determining ECFCs functionality in coronary artery disease (CAD) patients

Scientific Reports, 2022
Nitric oxide (NO . ) is critical for functionality of endothelial colony forming cells (ECFCs). Dimerization of endothelial nitric oxide synthase (eNOS) is must to produce NO . and tetrahydrobiopterin (BH4) plays a crucial role in stabilizing this state.
Atanu Sen, Archna Singh, Ambuj Roy, Sujata Mohanty, Nitish Naik, Mani Kalaivani, Lakshmy Ramakrishnan   +6 more
doaj   +1 more source

Effects of phototherapy on biopterin, neopterin, tryptophan, and behavioral neuroinflammatory reaction in patients with post-stroke depression. [PDF]

Sci Rep
Liu L, Wu Z, Lu Y, Lu W, Su G, Zhou Z.
europepmc   +3 more sources

Attenuating susceptibility to ascites in cold‐stressed broiler chickens fed canola meal‐based diets by supplementing arginine or guanidinoacetic acid, either alone or in combination with phenylalanine

Veterinary Medicine and Science, Volume 10, Issue 6, November 2024.
For ARG subscript: Decreased ascites mortality by increased plasma nitric oxide (NO), decreased RV:TV ratio and improved blood oxygen levels. For PHE subscript: Improved feed conversion ratio and decreased ascites susceptibility when combined with ARG or GAA.
Negin Delfani, Mohsen Daneshyar, Parviz Farhoomand, Sina Payvastegan, Younes Ali Alijoo, Gholamreza Najafi   +5 more
wiley   +1 more source

Comparative analysis of gene and disease selection in genomic newborn screening studies

Journal of Inherited Metabolic Disease, Volume 47, Issue 5, Page 945-970, September 2024.
Abstract Genomic newborn screening (gNBS) is on the horizon given the decreasing costs of sequencing and the advanced understanding of the impact of genetic variants on health and diseases. Key to ongoing gNBS pilot studies is the selection of target diseases and associated genes to be included.
Isabel R. Betzler, Maja Hempel, Ulrike Mütze, Stefan Kölker, Eva Winkler, Nicola Dikow, Sven F. Garbade, Christian P. Schaaf, Heiko Brennenstuhl   +8 more
wiley   +1 more source

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity [PDF]

, 2017
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus our attention on the chroman-4-one scaffold.
Alcantara, Laura M, Behrens, Birte, Borsari, Chiara, Cordeiro-da-Silva, Anabela, Costi, Maria Paola, Dello Iacono, Lucia, Di Pisa, Flavio, Ferrari, Stefania, Fontana, Vanessa, Freitas-Junior, Lucio H, Gul, Sheraz, Kuzikov, Maria, Landi, Giacomo, Mangani, Stefano, Moraes, Carolina B, Poehner, Ina, Pozzi, Cecilia, Santarem, Nuno, Santucci, Matteo, Wade, Rebecca C   +19 more
core   +3 more sources

Degeneration of Rat Retina is Paralleled by an Imbalance of the Redox Mechanism of Pteridines

Pteridines, 1996
The RCS rat suffers from a genetic degeneration of retinal cell We have examined the pattern of oxidized and reduced monapterin and biopterin in retinas from RCS retinas and controls.
Cremer-Bartels Gertrud
doaj   +1 more source

Pterins as Sensors of Response to the Application of Fe3+-Dextran in Piglets

Sensors, 2010
The aim of the presented study was to assess the effect of a single administration of Fe3+-dextran on immune cell counts and pterin biomolecule production as novel sensors of the piglets' immune system activation, and to determine concentrations of ...
Klara Breinekova, Martin Svoboda, Miriam Smutna   +2 more
doaj   +1 more source