Results 1 to 10 of about 1,078 (162)

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury [PDF]

Experimental Physiology, Volume 108, Issue 6, Page 874-890, 1 June 2023., 2023
New Findings What is the central question of this study? What are the physiological roles of cardiomyocyte-derived tetrahydrobiopterin (BH4) in cardiac metabolism and stress response? What is the main finding and its importance? Cardiomyocyte BH4 has
Bendall, Jennifer K, Channon, Keith M, Chu, Sandy M, Chuaiphichai, Surawee, Crabtree, Mark J, Douglas, Gillian, Heather, Lisa C, Miossec, Matthieu, Nicol, Thomas, Wright, Benjamin   +9 more
core   +3 more sources

Guide RNA structure design enables combinatorial CRISPRa programs for biosynthetic profiling. [PDF]

Nat Commun
Engineering metabolism to efficiently produce chemicals from multi-step pathways requires optimizing multi-gene expression programs to achieve enzyme balance.
Fontana J, Sparkman-Yager D, Faulkner I, Cardiff R, Kiattisewee C, Walls A, Primo TG, Kinnunen PC, Garcia Martin H, Zalatan JG, Carothers JM.   +10 more
europepmc   +3 more sources

Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology. [PDF]

Nitric Oxide, 2020
Macrophages are mononuclear phagocytes derived from haematopoietic progenitors that are widely distributed throughout the body. These cells participate in both innate and adaptive immune responses and lie central to the processes of inflammation ...
Bailey JD, Shaw A, McNeill E, Nicol T, Diotallevi M, Chuaiphichai S, Patel J, Hale A, Channon KM, Crabtree MJ.   +9 more
europepmc   +3 more sources

Genotypic variants of the tetrahydrobiopterin (BH4) biosynthesis genes in patients with hyperphenylalaninemia from different regions of Iran. [PDF]

Mol Genet Genomic Med
The clinical effect of reported variants is essential for genetic counseling and prenatal diagnosis in the patients' families and significant for the improvement of precision medicine. Abstract Background Hyperphenylalaninemia (HPA) is a metabolic disorder classified into phenylalanine‐4‐hydroxylase (PAH) and non‐PAH deficiency.
Nezhad SRK, Aligoodarzi PN, Rostami G, Shariati G, Galehdari H, Saberi A, Sedaghat A, Sedaghat A, Hamid M.   +8 more
europepmc   +2 more sources

Biopterin in Parkinson's disease. [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1987
Tetrahydrobiopterin is an essential co-factor in the natural synthesis of dopamine. Oral tetrahydrobiopterin was given in small doses to four patients with early Parkinson's disease but had no discernible effect.
W. Jacobson, P. O. Behan, A. P. Moore, W. L. F. Armarego   +3 more
openaire   +3 more sources

Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury

Advanced Materials, Volume 35, Issue 28, July 13, 2023., 2023
Engineered extracellular vesicles (eEVs) derived from adult dermal fibroblasts show enhanced intrapulmonary targeting and retention and can effectively deliver therapeutic cargo to the inflamed lung to reduce inflammation, mediate tissue repair, and drive metabolic changes that favor further activation of anti‐inflammatory pathways.
Ana I. Salazar‐Puerta, María A. Rincon‐Benavides, Tatiana Z. Cuellar‐Gaviria, Julian Aldana, Gabriela Vasquez Martinez, Lilibeth Ortega‐Pineda, Devleena Das, Daniel Dodd, Charles A. Spencer, Binbin Deng, David W. McComb, Joshua A. Englert, Samir Ghadiali, Diana Zepeda‐Orozco, Loren E. Wold, Daniel Gallego‐Perez, Natalia Higuita‐Castro   +16 more
wiley   +1 more source

Studies on the regulation of endothelial nitric oxide synthase in endothelial dysfunction [PDF]

, 2016
Ischaemic heart disease and cerebrovascular disease are the leading causes of morbidity and mortality in the world. The underlying progression of the disease is linked to a reduction in the bioavailability of nitric oxide. One factor contributing to this
Cerrato, Ruha
core   +1 more source

Mapping an atlas of tissue-specific drosophila melanogaster metabolomes by high resolution mass spectrometry [PDF]

, 2013
Metabolomics can provide exciting insights into organismal function, but most work on simple models has focussed on the whole organism metabolome, so missing the contributions of individual tissues.
A Kamleh, A Malmendal, A Malmendal, AA Jackson, C Jeulin, David G. Watson, DG Watson, DJ Creek, Dominika Korzekwa, DT Sullivan, G Di Paolo, G Fraenkel, GJ Blomquist, GX Quan, H Colinet, J Andrews, J Overgaard, Jacob Guy Bundy, JD Feala, JE Treherne, JL Hubby, JS Park, Julian A. T. Dow, KS Pedersen, L Coquin, L Pan, L Zheng, M Carvalho, M Parisi, M Rera, MA Kamleh, MA Kamleh, MF Wolfner, MM Green, Mohammed Al Bratty, MS Elias, N Vereshchagina, NE Braverman, P Niewiadomska, PA Robitaille, PS Shekhawat, R Tearle, S Buch, S Reisse, V Kostal, Venkateswara R. Chintapalli, VR Chintapalli, VR Chintapalli   +47 more
core   +3 more sources

Peripheral biopterin and neopterin in schizophrenia and depression

Psychiatry Research, 2021
Increasing evidence points to a causal involvement of inflammation in the pathogenesis of neuropsychiatric disorders, including major depressive disorder (MDD) and schizophrenia (SZ). Neopterin and biopterin may link peripheral immune system activation and central neurotransmitter alterations.
Flurin Cathomas, Anahita Rassi, Stefan Kaiser, Erich Seifritz, Beat Thöny, Federica Klaus, Federica Klaus, Rebecca Schlegel, Karoline Guetter   +8 more
openaire   +4 more sources

Unveiling Photodegradation and Photosensitization Mechanisms of Unconjugated Pterins

Chemistry – A European Journal, Volume 29, Issue 29, May 22, 2023., 2023
Despite the crucial role of unconjugated pterins in enzymatic processes and the photosensitization of singlet oxygen and other biomolecules, the mechanism underlying the photochemistry of these chromophores is still unclear. With the help of state‐of‐the‐art quantum‐chemical calculations, we shed light into the very fast triplet‐state population, their
Enrique M. Arpa, Inés Corral
wiley   +1 more source