Results 1 to 10 of about 1,785 (203)

Role of endothelial colony forming cells (ECFCs) Tetrahydrobiopterin (BH4) in determining ECFCs functionality in coronary artery disease (CAD) patients [PDF]

Scientific Reports, 2022
Nitric oxide (NO . ) is critical for functionality of endothelial colony forming cells (ECFCs). Dimerization of endothelial nitric oxide synthase (eNOS) is must to produce NO . and tetrahydrobiopterin (BH4) plays a crucial role in stabilizing this state.
Atanu Sen, Archna Singh, Ambuj Roy, Sujata Mohanty, Nitish Naik, Mani Kalaivani, Lakshmy Ramakrishnan   +6 more
doaj   +2 more sources

Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity. [PDF]

PLoS Pathogens, 2015
Decreased bioavailability of nitric oxide (NO) is a major contributor to the pathophysiology of severe falciparum malaria. Tetrahydrobiopterin (BH4) is an enzyme cofactor required for NO synthesis from L-arginine.
Matthew P Rubach, Jackson Mukemba, Salvatore Florence, Bert K Lopansri, Keith Hyland, Alicia D Volkheimer, Tsin W Yeo, Nicholas M Anstey, J Brice Weinberg, Esther D Mwaikambo, Donald L Granger   +10 more
doaj   +3 more sources

Dysregulation of tetrahydrobiopterin metabolism in myalgic encephalomyelitis/chronic fatigue syndrome by pentose phosphate pathway [PDF]

Journal of Central Nervous System Disease
Background Tetrahydrobiopterin (BH4) and its oxidized derivative dihydrobiopterin (BH2) were found to be strongly elevated in ME/CFS patients with orthostatic intolerance (ME + OI).
Sarojini Bulbule, Carl Gunnar Gottschalk, Molly E. Drosen, Daniel Peterson, Leggy A. Arnold, Avik Roy   +5 more
doaj   +2 more sources

Garlic prevents the oxidizing and inflammatory effects of sepsis induced by bacterial lipopolysaccharide at the systemic and aortic level in the rat. Role of trpv1 [PDF]

Heliyon, 2023
Garlic (Allium sativum) possesses healing properties for diseases like systemic arterial hypertension, cancer and diabetes, among others. Its main component, allicin, binds to the Transient Receptor Potential Vanilloid Type 1 (TRPV1).
Juan Carlos Torres-Narváez, Israel Pérez-Torres, Leonardo del Valle-Mondragón, Vicente Castrejón-Tellez, Verónica Guarner-Lans, María Sánchez-Aguilar, Elvira Varela-López, Álvaro Vargas-González, Gustavo Pastelín-Hernández, Julieta Anabell Díaz-Juárez   +9 more
doaj   +2 more sources

The Nitric Oxide System in Peripheral Artery Disease: Connection with Oxidative Stress and Biopterins [PDF]

Antioxidants, 2020
Peripheral artery disease (PAD) pathophysiology extends beyond hemodynamics to include other operating mechanisms, including endothelial dysfunction. Oxidative stress may be linked to endothelial dysfunction by reducing nitric oxide (NO) bioavailability.
Ahmed Ismaeel, Evlampia Papoutsi, Dimitrios Miserlis, Ramon Lavado, Gleb Haynatzki, George P. Casale, William T. Bohannon, Robert S. Smith, Jack Leigh Eidson, Robert Brumberg, Aaron Hayson, Jeffrey S. Kirk, Carlos Castro, Ian Sawicki, Charalambos Konstantinou, Luke P. Brewster, Iraklis I. Pipinos, Panagiotis Koutakis   +17 more
doaj   +2 more sources

Associations of Biopterins and ADMA with Vascular Function in Peripheral Microcirculation from Patients with Chronic Kidney Disease. [PDF]

Int J Mol Sci, 2023
Arefin S, Löfgren L, Stenvinkel P, Granqvist AB, Kublickiene K.   +4 more
europepmc   +3 more sources

Biopterin-Responsive Hyperphenylalaninemia

Journal of Nutritional Science and Vitaminology, 1992
Seymour Kaufman
openalex   +4 more sources

Comparative Study of Blood Neopterin and Biopterins in Patients with COVID-19 and Secondary Bacterial Infection. [PDF]

J Clin Med
Eguchi T, Niiyama S, Kamikokuryo C, Madokoro Y, Shimono K, Hara S, Ichinose H, Kakihana Y.   +7 more
europepmc   +3 more sources

Serum Neopterin, Biopterin, Tryptophan, and Kynurenine Levels in Patients with Fabry Disease [PDF]

Balkan Med J
Uçar T, Cansever MŞ, Isat E, Zubarioğlu T, Aktuğlu Zeybek AÇ, Topçu B, Seyahi N, Kıykım E.   +7 more
europepmc   +2 more sources

Radioimmunoassay for biopterin

Proceedings of the Japan Academy, Series B, 1979
Toshiharu Nagatsu, Tokio Yamaguchi, Takeshi Kato, Takashi Sugimoto, Sadao Matsuura   +4 more
openalex   +4 more sources