Results 21 to 30 of about 1,078 (162)

Activation of cGMP/Protein Kinase G Pathway in Postconditioned Myocardium Depends on Reduced Oxidative Stress and Preserved Endothelial Nitric Oxide Synthase Coupling [PDF]

, 2013
Altres ajuts: Redes Temáticas de Investigación Cooperativa Sanitaria (RETICS-RECAVA RD06/0014/0025); Comisión Interministerial en Ciencia y Tecnología (CICYT SAF/2008-03067); and Fondo Investigación Sanitaria (FIS-PI121738).The cGMP/protein kinase G (PKG)
Abad, Elena, Garcia-Dorado, David, Hernando, Víctor, Inserte, Javier, Poncelas-Nozal, Marcos, Universitat Autònoma de Barcelona, Vilardosa, Úrsula   +6 more
core   +1 more source

Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia [PDF]

, 2016
Maternal physiological hypercholesterolemia (MPH) allows a proper foetal development; however, maternal supraphysiological hypercholesterolemia (MSPH) associates with foetal endothelial dysfunction and early development of atherosclerosis.
Barros, Eric, Fuenzalida, Barbara, Gutierrez, Jaime, Leiva, Andrea, Pardo, Fabian, Salsoso, Rocio, Sobrevia, Luis, Toledo, Fernando   +7 more
core   +1 more source

Synthetic studies on pterin glycosides: the first synthesis of 2′-O-(α-d-glucopyranosyl)biopterin [PDF]

, 2009
L-Rhamnose was led, in a 14-step-sequence, to N2-(N,N-dimethylaminomethylene)-1′-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]biopterin (23), an appropriately protected precursor for 2′-O-glycosylation, while 4,6-di-O-acetyl-2,3-di-O-(4-methoxybenzyl)-α-
Cha, Cho, Choi, Coolidge, Crane, Fitzpatrick, Forrest, Gigg, Hanaya, Hanaya, Hanaya, Hanaya, Hanaya, Hanessian, Hatfield, Hiroki Baba, Hiroki Toyota, Hiroshi Yamamoto, Hough, Ibatullin, Ikawa, Kaufman, Kaufman, Kwon, Lee, Lemieux, Lin, Lönn, Marletta, Matsunaga, Ness, Noguchi, Saito, Stewart, Suzuki, Tadashi Hanaya, Taylor, Wolfrom, Wulff, Yin   +39 more
core   +1 more source

Pterins as diagnostic markers of mechanical and impact-induced trauma: A systematic review [PDF]

, 2022
We performed a systematic review of the literature to evaluate pterins as biomarkers of mechanical and impact-induced trauma. MEDLINE and Scopus were searched in March 2019.
Baxter-Parker G, Gieseg, Steven, Lindsay A   +2 more
core   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Acrylamide induces spatiotemporal metabolic profiling disturbance via targeting taurine and hypotaurine metabolism during early zebrafish development

Food Frontiers, Volume 6, Issue 1, Page 282-299, January 2025.
This study provides in‐depth evidence on the metabolic regulation of zebrafish embryos with acrylamide exposure at different zebrafish developmental stages. The pattern of significantly changed metabolites revealed that acrylamide exposure has a detrimental effect on early heart development in zebrafish due to the inhibition of de novo synthesis of ...
Anli Wang, Jia Zeng, Xiaoran Song, Yingyu Huang, Jianxin Yao, Li Zhu, Yuchen Gao, Binjie Wang, Yuanzhao Wu, Zhongshi Xu, Ruonan Zheng, Yazhou Qin, Jiye Wang, Weixuan Yao, Xuzhi Wan, Haoyu Li, Pan Zhuang, Jingjing Jiao, Shulin Zhuang, Yu Zhang   +19 more
wiley   +1 more source

Endothelial cell tetrahydrobiopterin modulates sensitivity to ang (angiotensin) II–induced vascular remodeling, blood pressure, and abdominal aortic aneurysm [PDF]

, 2018
GTPCH (GTP cyclohydrolase 1, encoded by Gch1) is required for the synthesis of tetrahydrobiopterin; a critical regulator of endothelial NO synthase function.
Channon, Keith M., Chuaiphichai, Surawee, Douglas, Gillian, Hale, Ashley B., Lygate, Craig A., McNeill, Eileen, Patel, Jyoti, Rashbrook, Victoria S., Trelfa, Lucy   +8 more
core   +1 more source

Dystonia and Biopterin Deficiency

Pediatric Neurology Briefs, 1988
Five patients with childhood dystonia associated with reduced CSF biopterin, responsive to levodopa, and characterized by diurnal and exertional variation are reported from the Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD.
openaire   +3 more sources

A Single‐Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates

JIMD Reports, Volume 66, Issue 1, January 2025.
ABSTRACT Background Tetrahydrobiopterin (BH4) deficiencies comprise a group of five neurometabolic disorders caused by five genetic defects responsible for BH4 biosynthesis and regeneration. Their global prevalence remains unknown, and variance exists among different countries.
Omar Jarrah, Mahmood Nouri, Aisha Al Shamsi   +2 more
wiley   +1 more source

Tetrahydrobiopterin protects against hypertrophic heart disease independent of myocardial nitric oxide synthase coupling [PDF]

, 2016
Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide.
Bedja, D, Carnicer, R, Casadei, Barbara, Channon, KM, Duglan, D, Hahn, VS, Hashimoto, T, Kass, DA, Recalde, A, Sivakumaran, V, Zhu, G   +10 more
core   +3 more sources