Results 41 to 50 of about 1,785 (203)

Pterins as diagnostic markers of mechanical and impact-induced trauma: A systematic review [PDF]

, 2022
We performed a systematic review of the literature to evaluate pterins as biomarkers of mechanical and impact-induced trauma. MEDLINE and Scopus were searched in March 2019.
Baxter-Parker G, Gieseg, Steven, Lindsay A   +2 more
core   +1 more source

Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild

American Journal of Primatology, Volume 87, Issue 10, October 2025.
Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Verena Behringer, Caroline Deimel
wiley   +1 more source

Tetrahydrobiopterin Responsive Hyperphenylalaninemia without Biopterin Deficiency

pteridines, 2000
Hyperphenylalaninemia (HPA) results from a deficiency of the enzyme phenylalanine hydroxylase (PAH) or of its cofactor, tetrahydrobiopterin (BH4). In 1999, Kure et al reported that some patients with PAH deficiency showed lowering of blood Phe levels after BH4 loading (1). We found several patients with HPA whose serum phenylalanine levels decreased at
Shintaku Haruo, Asada Minoru, Sawada Yoshitomo, Yamano Tsunekazu   +3 more
openaire   +2 more sources

Dissecting the genomic regions, candidate genes and pathways using multi‐locus genome‐wide association study for stem rot disease resistance in groundnut

The Plant Genome, Volume 18, Issue 3, September 2025.
Abstract Stem rot, caused by Sclerotium rolfsii Sacc., is a devastating soil‐borne disease causing up to 80% yield losses in groundnut globally. To dissect the genetic basis of resistance, we evaluated a diverse minicore germplasm panel over 3 years in stem rot sick‐field conditions.
H. V. Veerendrakumar, Hari Kishan Sudini, Bangaru Kiranmayee, Talwar Devika, Sunil S. Gangurde, R. P. Vasanthi, A. R. Nirmal Kumar, Sandip K. Bera, Baozhu Guo, Boshou Liao, Rajeev K. Varshney, Manish K. Pandey   +11 more
wiley   +1 more source

Comparative Genomics Insights Into the Evolutionary Disparities Between Nitroplast‐Evolved Ecotype UCYN‐A2 and Its Closest Relative UCYN‐A1

Ecology and Evolution, Volume 15, Issue 7, July 2025.
This paper conducted comparative genomic analyses among seven UCYN‐A strains in genome content, gene structure, and key metabolic protein genes. In general, our results demonstrated considerable disparities between UCYN‐A1 and UCYN‐A2, providing insights into the evolution of UCYN‐A and nitroplast.
Shiyun Han, Sijia Zhang, Wen Ge, Jianke Yang, Hui Peng, Jinming Gao, Mengsa Zhang, Yingying Xiao, Dongsheng Du, Xianzhao Kan   +9 more
wiley   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Mutationen im PTS-Gen und mögliche Auswirkungen auf Funktion und Struktur der 6-Pyruvoyl-Tetrahydropterin-Synthase [PDF]

, 2002
Background: Research on Juvenile Idiopathic Arthritis (JIA) should support patients, caregivers/parents (carers) and clinicians to make important decisions in the consulting room and eventually to improve the lives of patients with JIA.
Armbrust, Wineke, Bookelman, Sanne L., Cappon, Jeannette, Cowan, Katherine, De Boer, Joke, Dedding, Christine, Fernhout, Marlous J., Jongsma, Karin R., Kamphuis, Sylvia, Lelieveld, Otto T.H.M., Muller, Petra C.E.Hissink, Olsder, Wendy, Schatorjé, Ellen, Schoemaker, Casper G., Swart, Joost F., Van Den Berg, J. Merlijn, Van Der Net, Janjaap, Van Loosdregt, Jorg, Van Rensen, Annemiek, Van Vliet, Rens, Vastert, Sebastiaan J., Versluis, Els, Verwoerd, Anouk, Whiting, Caroline, Wulffraat, Nico M.   +24 more
core   +9 more sources

Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia [PDF]

, 2016
Maternal physiological hypercholesterolemia (MPH) allows a proper foetal development; however, maternal supraphysiological hypercholesterolemia (MSPH) associates with foetal endothelial dysfunction and early development of atherosclerosis.
Barros, Eric, Fuenzalida, Barbara, Gutierrez, Jaime, Leiva, Andrea, Pardo, Fabian, Salsoso, Rocio, Sobrevia, Luis, Toledo, Fernando   +7 more
core   +1 more source

Acrylamide induces spatiotemporal metabolic profiling disturbance via targeting taurine and hypotaurine metabolism during early zebrafish development

Food Frontiers, Volume 6, Issue 1, Page 282-299, January 2025.
This study provides in‐depth evidence on the metabolic regulation of zebrafish embryos with acrylamide exposure at different zebrafish developmental stages. The pattern of significantly changed metabolites revealed that acrylamide exposure has a detrimental effect on early heart development in zebrafish due to the inhibition of de novo synthesis of ...
Anli Wang, Jia Zeng, Xiaoran Song, Yingyu Huang, Jianxin Yao, Li Zhu, Yuchen Gao, Binjie Wang, Yuanzhao Wu, Zhongshi Xu, Ruonan Zheng, Yazhou Qin, Jiye Wang, Weixuan Yao, Xuzhi Wan, Haoyu Li, Pan Zhuang, Jingjing Jiao, Shulin Zhuang, Yu Zhang   +19 more
wiley   +1 more source

Neurological aspects of biopterin metabolism. [PDF]

Archives of Disease in Childhood, 1986
Plasma total biopterin concentration was measured by bioassay in 59 infants with hyperphenylalaninaemia and in 50 children with developmental regression and or movement disorder with normal plasma phenylalanine concentrations. In infants with raised phenylalanine concentrations plasma biopterin concentrations were significantly raised in proportion to ...
I, Smith, R J, Leeming, N P, Cavanagh, K, Hyland   +3 more
openaire   +2 more sources