Mouse models for inherited monoamine neurotransmitter disorders
Journal of Inherited Metabolic Disease, Volume 47, Issue 3, Page 533-550, May 2024.Abstract Several mouse models have been developed to study human defects of primary and secondary inherited monoamine neurotransmitter disorders (iMND). As the field continues to expand, current defects in corresponding mouse models include enzymes and a molecular co‐chaperone involved in monoamine synthesis and metabolism (PAH, TH, PITX3, AADC, DBH ...
Beat Thöny +4 more
wiley +1 more source
Medicinal Research Reviews, Volume 44, Issue 3, Page 1055-1120, May 2024.Abstract Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of Leishmania protozoa, which are spread by the bite of infected sandflies. There are three main forms of the disease: cutaneous leishmaniasis (CL, the most common), visceral leishmaniasis (VL, also known as kala‐azar, the most serious), and mucocutaneous ...
Miguel Marín +4 more
wiley +1 more source
Effects of peri-operative statin treatment on atrial electrical properties, post-operative atrial fibrillation and in-hospital clinical outcomes in patients undergoing elective cardiac surgery [PDF]
, 2016 Surgical myocardial revascularization remains the standard of care for patients with multi-vessel coronary artery disease. A growing body of evidence indicates that systemic inflammation and myocardial oxidative stress are associated with the ...
Jayaram, Raja
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Disorders of biopterin metabolism [PDF]
Journal of Inherited Metabolic Disease, 2009 SummaryDefects in the metabolism or regeneration of tetrahydrobiopterin (BH4) were initially discovered in patients with hyperphenylalaninaemia who had progressive neurological deterioration despite optimal metabolic control (malignant hyperphenylalaninaemia).
openaire +4 more sources
Fast Label‐Free Metabolic Profile Recognition Identifies Phenylketonuria and Subtypes
Advanced Science, Volume 11, Issue 15, April 17, 2024.The plasmonic silver nanoshells constructed microarrays are used for laser desorption/ionization mass spectrometry (MS) detection of phenylketonuria (PKU) by recognizing metabolic profile in dried blood spot (DBS) samples. The platform achieves precise PKU diagnosis and subtype identification in a single DBS test with a fast, label‐free, and low‐cost ...
Haiyang Su +11 more
wiley +1 more source
Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics [PDF]
, 2018 In the apolipoprotein E–deficient mouse, the gut microbiota has an impact on the development of atherosclerosis, but whether such correlations are also present in rats requires investigation.
Bornfeldt, Karin E. +14 more
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Gene therapy for neurotransmitter‐related disorders
Journal of Inherited Metabolic Disease, Volume 47, Issue 1, Page 176-191, January 2024.Abstract Inborn errors of neurotransmitter (NT) metabolism are a group of rare, heterogenous diseases with predominant neurological features, such as movement disorders, autonomic dysfunction, and developmental delay. Clinical overlap with other disorders has led to delayed diagnosis and treatment, and some conditions are refractory to oral ...
Wing Sum Chu +3 more
wiley +1 more source
Electron paramagnetic resonance characterization of tetrahydrobiopterin radical formation in bacterial nitric oxide synthase compared to mammalian nitric oxide synthase. [PDF]
, 2012 International audienceH(4)B is an essential catalytic cofactor of the mNOSs. It acts as an electron donor and activates the ferrous heme-oxygen complex intermediate during Arg oxidation (first step) and NOHA oxidation (second step) leading to nitric ...
Brunel, Albane +2 more
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Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system. [PDF]
, 2017 There are several reviews on NO and hydrogen sulfide (H2 S) and their role in vascular diseases in the current relevant literature. The aim of this review is to discuss, within the limits of present knowledge, the interconnection between these two ...
Bucci, M., Cirino, G, Vellecco, V
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Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis. [PDF]
, 2017 Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis ...
Ackerman, Hans +14 more
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