Oxidative Stress and Immune System in Vitiligo and Thyroid Diseases. [PDF]
, 2015 Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis.
Colucci, Roberta +2 more
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CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.The NMOSD model demonstrated substantial neuroinflammation and neural injury, accompanied by imbalances in gut microbiota, peripheral inflammation, and metabolic disorders, suggesting a potentially vicious cycle that exacerbates disease pathogenesis.
Xinying Yang +15 more
wiley +1 more source
Journal of Inherited Metabolic Disease, Volume 47, Issue 3, Page 494-508, May 2024.Abstract Proteostatic regulation of tyrosine hydroxylase (TH), the rate‐limiting enzyme in dopamine biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. Variants of the TH gene are associated with tyrosine hydroxylase deficiency (THD), a rare disorder with a wide phenotypic spectrum and variable response to treatment ...
Kunwar Jung‐KC +10 more
wiley +1 more source
Dystonia and Biopterin Deficiency
Pediatric Neurology Briefs, 1988 Five patients with childhood dystonia associated with reduced CSF biopterin, responsive to levodopa, and characterized by diurnal and exertional variation are reported from the Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD.
openaire +3 more sources
Mouse models for inherited monoamine neurotransmitter disorders
Journal of Inherited Metabolic Disease, Volume 47, Issue 3, Page 533-550, May 2024.Abstract Several mouse models have been developed to study human defects of primary and secondary inherited monoamine neurotransmitter disorders (iMND). As the field continues to expand, current defects in corresponding mouse models include enzymes and a molecular co‐chaperone involved in monoamine synthesis and metabolism (PAH, TH, PITX3, AADC, DBH ...
Beat Thöny +4 more
wiley +1 more source
Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics [PDF]
, 2018 In the apolipoprotein E–deficient mouse, the gut microbiota has an impact on the development of atherosclerosis, but whether such correlations are also present in rats requires investigation.
Bornfeldt, Karin E. +14 more
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Effects of peri-operative statin treatment on atrial electrical properties, post-operative atrial fibrillation and in-hospital clinical outcomes in patients undergoing elective cardiac surgery [PDF]
, 2016 Surgical myocardial revascularization remains the standard of care for patients with multi-vessel coronary artery disease. A growing body of evidence indicates that systemic inflammation and myocardial oxidative stress are associated with the ...
Jayaram, Raja
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Dispel some mist on circulating biopterins: measurement, physiological interval and pathophysiological implication [PDF]
, 2023 Shao‐Ting Wang, Haibo Wang
openalex +1 more source
Quantification of Neurotransmitters in Mouse Brain Tissue by Using Liquid Chromatography Coupled Electrospray Tandem Mass Spectrometry [PDF]
, 2014 A simple and rapid liquid chromatography tandem mass spectrometry method has been developed for the determination of BH4, DA, 5-HT, NE, EP, Glu, and GABA in mouse brain using epsilon-acetamidocaproic acid and isotopically labeled neurotransmitters as ...
Hak Rim Kim +3 more
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Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression [PDF]
, 2018 GTP cyclohydrolase I (GTPCH) catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases (NOS).
Al Haj Zen, Ayman +9 more
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