Results 191 to 200 of about 72,831 (298)

Membranes and bioreactors

open access: yesInternational Journal of Biochemistry, 1990
Carole A. Heath, Georges Belfort
openaire   +2 more sources

Minimizing batch‐to‐batch variability of a live virus vaccine by process analytical technologies

open access: yesBiotechnology Progress, EarlyView.
Abstract For bioprocesses producing live virus, such as enterovirus Coxsackievirus A21, viral titer (infectivity basis) decay rates can exceed 30% within a day. Consequently, harvest timing is paramount. To optimize titer at harvest, a continuous viral product titer model was generated to elucidate kinetics.
Katherine Forrester   +4 more
wiley   +1 more source

A digital shadow of CAR T cell expansion in a perfusion bioreactor: Informing optimal harvest times for autologous cell therapy

open access: yesBiotechnology Progress, EarlyView.
Using online metabolite data from the first few days of a bioreactor run, the digital shadow can forecast the cell concentration in real‐time with an accuracy of 13% (standard deviation ≈ 6%). These predictions can guide the optimal harvest time of CAR T cells for subsequent re‐infusion into the patient.
Joseph R. Egan   +11 more
wiley   +1 more source

Membrane Separation Bioreactors for Wastewater Treatment [PDF]

open access: bronze, 2000
C. Visvanathan   +2 more
openalex   +1 more source

A recurrent neural network for soft sensor development using CHO stable pools in fed‐batch process for SARS‐CoV‐2 spike protein production as a vaccine antigen

open access: yesBiotechnology Progress, EarlyView.
Abstract Fed‐batch recombinant therapeutic protein (RTP) production processes utilizing Chinese Hamster Ovary (CHO) cells can take a long period of time (>10 days). Within this period, not all critical features may be measured routinely, and in fact, some are only measured once the process is terminated, complicating decision making.
Sebastian‐Juan Reyes   +4 more
wiley   +1 more source

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