Results 191 to 200 of about 72,831 (298)
Carole A. Heath, Georges Belfort
openaire +2 more sources
Minimizing batch‐to‐batch variability of a live virus vaccine by process analytical technologies
Abstract For bioprocesses producing live virus, such as enterovirus Coxsackievirus A21, viral titer (infectivity basis) decay rates can exceed 30% within a day. Consequently, harvest timing is paramount. To optimize titer at harvest, a continuous viral product titer model was generated to elucidate kinetics.
Katherine Forrester+4 more
wiley +1 more source
Characterizing the effect of impeller design in plant cell fermentations using CFD modeling. [PDF]
Manickavasagam VM+3 more
europepmc +1 more source
Mammalian cell retention devices for stirred perfusion bioreactors.
Steven M. Woodside+2 more
openalex +2 more sources
NADH-Regulated Metabolic Model for Growth of Methylosinus trichosporium OB3b. Cometabolic Degradation of Trichloroethene and Optimization of Bioreactor System Performance [PDF]
Elisabeth Marijn Sipkema+4 more
openalex +1 more source
Using online metabolite data from the first few days of a bioreactor run, the digital shadow can forecast the cell concentration in real‐time with an accuracy of 13% (standard deviation ≈ 6%). These predictions can guide the optimal harvest time of CAR T cells for subsequent re‐infusion into the patient.
Joseph R. Egan+11 more
wiley +1 more source
Drying of Functional Hydrogels: Development of a Workflow for Bioreactor-Integrated Freeze-Drying of Protein-Coated Alginate Microcarriers for iPS Cell-Based Screenings. [PDF]
Balsters JM+6 more
europepmc +1 more source
Membrane Separation Bioreactors for Wastewater Treatment [PDF]
C. Visvanathan+2 more
openalex +1 more source
Abstract Fed‐batch recombinant therapeutic protein (RTP) production processes utilizing Chinese Hamster Ovary (CHO) cells can take a long period of time (>10 days). Within this period, not all critical features may be measured routinely, and in fact, some are only measured once the process is terminated, complicating decision making.
Sebastian‐Juan Reyes+4 more
wiley +1 more source