Results 211 to 220 of about 96,256 (296)

Beyond omics: From descriptive profiling to causal and scalable design of fermentation microbiomes

iMeta, EarlyView.
Fermentation microbiomes play essential roles in food production, feed preservation, waste valorization, and diverse sustainable industrial processes. Although multi‐omics and systems biology have substantially advanced our understanding of their assembly, interactions, and functional dynamics, industrial translation remains constrained by fragmented ...
Dongze Niu, Huili Pang, Xuekai Wang, Liang Song, Jing Zhang, Ansah Terry, Junfeng Li, Jingwen Cao, Qinhua Liu, Dayong Han, Jidong Wang, Jong Geun Kim, Kazuo Ataku, Smerjai Bureenok, Zhongfang Tan, Fengyan Bai, Tao Shao, Taoli Huhe, Lifeng Wang, Peijie Han, Chuncheng Xu, Fuyu Yang, Yimin Cai   +22 more
wiley   +1 more source

Rapid Volumetric Bioprinting Coupled with Dynamic Perfusion Enhances Human Hepatic Organoid Toxicity Testing. [PDF]

Cells
Tao Y, Núñez Bernal P, Ginés Rodriguez N, Bouwmeester MC, Walraven TJG, Wanders D, Kock L, Heck NV, Schneeberger-Verjaal K, van der Laan LJW, Spee B.   +10 more
europepmc   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Performance of a modular robotic cluster matches skilled human operators for complex cell therapy manufacturing tasks. [PDF]

Int J Pharm X
Sadhu S, Schmittlein B, Lares A, Cheng C, Chen X, Bhatia V, Zha W, Wah S, Nayak S, Uboldi M, Yu Y, Wang J, Zhang W, Bhanap PP, Ji Y, Scheffler A, Wilson J, Welch D, Gkitsas-Long N, Retherford AJ, Tunuguntla R, Melocchi A, Girard A, Parietti F, Feldman SA, Esensten JH.   +25 more
europepmc   +1 more source

Removal of pharmaceuticals from municipal wastewater using a powdered activated carbon‐supplemented moving bed membrane bioreactor

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The new European Union Wastewater Directive 2024/3019 requires upgrading sewage treatment plants to achieve 80% removal of micropollutants. This study aimed to compare different Powdered Activated Carbon dosing strategies within a hybrid Moving Bed‐Membrane Bioreactor (PAC‐MB‐MBR) system, to evaluate its performance and to study the
Athanasia Iliopoulou, Petros Mastoras, Georgia Gatidou, Kallisti Skarveli, Konstantina Adamaki, Olga S Arvaniti, Maria Aloupi, Michail S Fountoulakis, Athanasios S Stasinakis   +8 more
wiley   +1 more source

Bio-process development for sustainable, large-scale production of LAB-oligosaccharides as a potential anti-colon-cancer metabolites produced by Lactobacillus acidophilus 20079. [PDF]

Microb Cell Fact
Kenawy AM, Abo-Zaid GA, Taha TH, Ragab AE, Al-Madboly LA, El-Deeb NM.   +5 more
europepmc   +1 more source

Production of recombinant human granulocyte‐macrophage colony‐stimulating factor in thermoinducible E. coli: Tuning inclusion body architecture and protein yield via dissolved oxygen control

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil, Norma A Valdez‐Cruz, Sara Restrepo‐Pineda, Nuria Sánchez‐Puig, Rafael Vázquez‐Duhalt, Rubén D Cadena‐Nava, Néstor O Pérez, Mauricio A Trujillo‐Roldán   +7 more
wiley   +1 more source

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal, Christina Chan, S Patrick Walton   +2 more
wiley   +1 more source

Challenges and knowledge gaps in corrosion and materials degradation of bioreactors for waste feedstocks. [PDF]

Discov Mater
Ramos-Suarez M, Zhang Y, Wharton J, Heaven S.   +3 more
europepmc   +1 more source

Disclosing the production of fungal chitinases and proteases using insect by‐products as substrates in solid‐state fermentation

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The world population is projected to reach nearly 9.7 billion by 2050, significantly increasing the demand for novel and sustainable protein sources. Edible insects, such as Tenebrio molitor, emerge as promising alternatives due to their high nutritional value, but adult insects and frass are direct and abundant by‐products of this ...
Borja Fernández, Helena Fernandes, Nuno Muñoz‐Seijas, Francisco Soto‐Beltrán, José Manuel Domínguez, Helena Peres, José Manuel Salgado   +6 more
wiley   +1 more source