Results 231 to 240 of about 185,824 (352)

COMPUTER SIMULATION OF A HOLLOW-FIBER BIOREACTOR: HEPARAN REGULATED GROWTH FACTORS-RECEPTORS BINDING AND DISSOCIATION ANALYSIS

, 2011
Changjiang Zhang
openalex   +1 more source

Non-GMP plasmid production for transient transfection in bioreactors [PDF]

, 2001
Georg H. Schmid, Ernst‐Jürgen Schlaeger, Beat Wipf   +2 more
openalex   +1 more source

Advancing Malic Acid Production of Aspergillus oryzae: Combined Process Optimization and Application of Various Substrates

Biotechnology and Bioengineering, EarlyView.
ABSTRACT In light of climate change and growing resource scarcity, microbial production of organic acids offers a sustainable alternative to fossil‐based chemical synthesis. In this study, malic acid production by Aspergillus oryzae was optimized through cultivation temperature adjustment and biotin supplementation, while organic acid formation from ...
Lukas Hartmann, Anke Neumann, Dirk Holtmann, Björn Vater, Thomas Hahn, Susanne Zibek, Katrin Ochsenreither   +6 more
wiley   +1 more source

Capacitance Technology Enables Automated Feeding, Improved Expansion, and Higher Throughput of CAR-T Cell Stirred-Tank Bioreactor Cultures. [PDF]

Biotechnol J
Colao IL, Cunningham J, Lee M, Goldrick S, Rafiq QA.   +4 more
europepmc   +1 more source

Raman Spectroscopy–Based Glucose Feed Control Automates Malic Acid Fermentation

Biotechnology and Bioengineering, EarlyView.
Raman spectroscopy enables automated, closed‐loop glucose feeding for malic acid production with Ustilago trichophora. Online PLS regression of glucose and malic acid provides input for PID control to maintain 20 g/L glucose. The feed is dynamically adjusted and stopped in response to metabolic demand and product inhibition, demonstrating practical ...
Luca Antonia Grebe, Katharina Hürter, Dominik Engel, Alexander Walter Wilhelm Echtermeyer, Mafalda S. Santos, Laurin Röder, Valentin Steier, Jörn Viell, Jørgen Barsett Magnus   +8 more
wiley   +1 more source

Modular bioreactor for multi-well electrical stimulation of <i>in vitro</i> cardiac tissue engineering constructs. [PDF]

Lab Chip
Cook SH, Twiddy J, Li Y, Ali KM, Zha D, Gaddy K, Mabe L, Huang K, Cheng K, Daniele MA, Gluck JM.   +10 more
europepmc   +1 more source

Methodology for the Analysis of Life Science Innovation Systems (ALSIS) and its Application to Three Case Studies [PDF]

, 2012
Mastroeni, Michele, Mittra, James, Tait, Joyce   +2 more
core  

Production of High-Quality Particulate Methane Monooxygenase in High Yields from Methylococcus capsulatus (Bath) with a Hollow-Fiber Membrane Bioreactor

, 2003
Steve S.‐F. Yu, Kelvin H.‐C. Chen, Mandy Y.-H. Tseng, Yane‐Shih Wang, Chiu-Feng Tseng, Yu‐Ju Chen, Ded‐Shih Huang, Sunney I. Chan   +7 more
openalex   +2 more sources

Addressing Small Data Challenges in Biopharmaceutical Development and Manufacturing: A Mini Review of Multi‐Fidelity Techniques

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The growing demand for biopharmaceutical products reflects their effectiveness in medical treatments. However, developing new biopharmaceuticals remains a major bottleneck, often taking up to a decade before market approval. Machine learning (ML) models have the potential to accelerate this process, but their success depends on access to large
Mohammad Golzarijalal, Uwe Aickelin, Ellen Otte   +2 more
wiley   +1 more source

Using <i>Novosphingobium aromaticivorans</i> for Concurrent Production of Intracellular and Extracellular Products from Aromatics Extracted from Poplar Biomass. [PDF]

ACS ES T Eng
Kim B, Hall BW, Haak DV, Coplien J, Karlen SD, Donohue TJ, Noguera DR.   +6 more
europepmc   +1 more source