Results 41 to 50 of about 71,391 (320)

Macro-scale Topology Optimization for Controlling Internal Shear Stress in a Porous Scaffold Bioreactor [PDF]

Biotechnology & Bioengineering, 109(7):1844-1854 (2012), 2011
Shear stress is an important physical factor that regulates proliferation, migration and morphogenesis. In particular, the homeostasis of blood vessels is dependent on shear stress. To mimic this process ex vivo, efforts have been made to seed scaffolds with vascular and other cell types in the presence of growth factors and under pulsatile flow ...
arxiv   +1 more source

Computational fluid dynamics simulation improves the design and characterization of a plug‐flow‐type scale‐down reactor for microbial cultivation processes

Biotechnology Journal, Volume 18, Issue 1, January 2023., 2023
Graphical Abstract and Lay Summary The heterogenous production conditions in large‐scale bioreactors cause scale‐up problems, such as reduced biomass or product yield, to occur during bioprocesses. In this study, we designed a two‐compartment scale‐down reactor and used it to simulate large‐scale heterogenous production conditions, allowing us to ...
Florian Mayer, Monika Cserjan‐Puschmann, Benedikt Haslinger, Anton Shpylovyi, Christian Sam, Miroslav Soos, Rainer Hahn, Gerald Striedner   +7 more
wiley   +1 more source

Identification of a prognostic ferroptosis-related lncRNA signature in the tumor microenvironment of lung adenocarcinoma

Cell Death Discovery, 2021
Ferroptosis is closely linked to various cancers, including lung adenocarcinoma (LUAD); however, the factors involved in the regulation of ferroptosis-related genes are not well established.
Yugang Guo, Zhongyu Qu, Dandan Li, Fanghui Bai, Juan Xing, Qian Ding, Jiawei Zhou, Lunguang Yao, Qian Xu   +8 more
doaj   +1 more source

Scalable Manufacturing of Radiation‐Tolerant Potentiometric Electrodes: A Systematic Transition from Laboratory to Semiautomated Fabrication

Advanced Engineering Materials, EarlyView.
Laboratory protocols for producing thin‐film pH electrodes for sterilized single‐use technologies have been successfully developed into a semiautomated workflow, with higher throughput and precision of membrane thickness. Accuracies are within 0.05 pH units versus ground truth, and uncertainty analysis reveals the largest sources of error to be derived
Bingyuan Zhao, Aiganym Yermembetova, Benson Kunhung Tsai, Jialong Huang, Alexander Wei   +4 more
wiley   +1 more source

Differentiation roadmap of embryonic Sertoli cells derived from mouse embryonic stem cells

Stem Cell Research & Therapy, 2019
Background Embryonic Sertoli cells (eSCs) play an important role in sex determination and in male gonad development which makes them a very useful cell type for therapeutic applications.
Chenze Xu, Ali Mohsin, Yanxia Luo, Lili Xie, Yan Peng, Qizheng Wang, Haifeng Hang, Yingping Zhuang, Meijin Guo   +8 more
doaj   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism

Biotechnology for Biofuels, 2019
Background Acetate, an economical industrial chemical, which is also the precursor of acetyl-CoA, could serve as an alternative substrate for biomanufacturing.
Qin Xu, Chenxiao Bai, Yiqi Liu, Lili Song, Lin Tian, Yunfeng Yan, Jinfeng Zhou, Xiangshan Zhou, Yuanxing Zhang, Menghao Cai   +9 more
doaj   +1 more source

Iterative gene integration mediated by 26S rDNA and non-homologous end joining for the efficient production of lycopene in Yarrowia lipolytica

Bioresources and Bioprocessing, 2023
Because of its potent antioxidant effects, lycopene has been used in various industries including, but not limited to, food, medical, and cosmetic industries.
Zhen Luo, Jiang-Ting Shi, Xin-Liang Chen, Jun Chen, Feng Liu, Liu-Jing Wei, Qiang Hua   +6 more
doaj   +1 more source

Advances in the structural characterization of complexes of therapeutic antibodies with PD-1 or PD-L1

mAbs, 2023
Antibody-based immune checkpoint blockade (ICB)-based therapeutics have become effective clinical applications for cancers. Applications of monoclonal antibodies (mAbs) to de-activate the PD-1-PD-L1 pathway could effectively reverse the phenotype of ...
Mengzhen Jiang, Man Liu, Guodi Liu, Jiawen Ma, Lixin Zhang, Shenlin Wang   +5 more
doaj   +1 more source

Dynamics and Control of Oscillatory Bioreactors [PDF]

arXiv, 2023
Bioreactors are widely used in many industries to generate a range of products using various host cells e.g., yeast, insect, and mammalian cells. Depending on the process, product, and host cell, some bioreactors exhibit sustained periodic behavior in key process variables such as metabolite concentrations, biomass, and product titer.
arxiv