Microtechnology in Space Bioreactors
Space biology is a young and rapidly developing discipline comprising basic research and biotechnology. In the next decades it will play a prominent role in the International Space Station (ISS). Therefore, there is an increasing demand for sophisticated instrumentation to satisfy the requirements of the future projects in space biology.
Isabelle Walther+4 more
openaire +4 more sources
Growth behavior of human adipose tissue-derived stromal/stem cells at small scale : numerical and experimental investigations [PDF]
Human adipose tissue-derived stromal/stem cells (hASCs) are a valuable source of cells for clinical applications, especially in the field of regenerative medicine.
Eibl, Dieter+3 more
core +1 more source
Tailored 3D Lattice Microstructures for Enhanced Functionality in Blood‐Gas Exchange
Common hollow fiber structures are associated with inhomogeneous flow, leading to many complications in the medical application of extracorporeal membrane oxygenation. Using locally adapted lattice structures, the overall flow distribution can be manipulated.
Kai P. Barbian+10 more
wiley +1 more source
IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex
This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv+6 more
wiley +1 more source
High density culturing of porcine hepatocytes immobilized on nonwoven polyurethane-based biomatrices [PDF]
Objective: Hepatocytes are increasingly used as functional units in bioartificial liver devices. The objective of the present study was to investigate the feasibility of culturing porcine hepatocytes in high density on a novel polyurethane-based nonwoven
Castell, M. J.+6 more
core +1 more source
Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang+4 more
wiley +1 more source
Engineering thick tissues - the vascularisation problem [PDF]
The ability to create thick tissues is a major tissue engineering challenge, requiring the development of a suitable vascular supply. Current trends are seeing the utilization of cells seeded into hybrid matrix/scaffold systems to create in vitro ...
H C H Ko, B K Milthorpe, C D McFarland
doaj
Os hidrocarbonetos aromáticos policíclicos (HAPs) são compostos mutagênicos e carcinogênicos aos humanos e aos animais que são introduzidos no ambiente em grandes quantidades, devido às atividades relacionadas à extração, ao transporte, ao refino, à ...
Rodrigo Josemar Seminoti Jacques+3 more
doaj +1 more source
Numerical Solution of a Complete Formulation of Flow in a Perfusion Bone-Tissue Bioreactor Using Lattice Boltzmann Equation Method [PDF]
We report the key findings from numerical solutions of a model of transport within an established perfusion bioreactor design. The model includes a complete formulation of transport with fully coupled convection-diffusion and scaffold cell attachment. It also includes the experimentally determined internal (Poly-L-Lactic Acid (PLLA)) scaffold boundary,
arxiv
Minimal-time bioremediation of natural water resources [PDF]
We study minimal time strategies for the treatment of pollution of large volumes, such as lakes or natural reservoirs, with the help of an autonomous bioreactor. The control consists in feeding the bioreactor from the resource, the clean output returning
Cabrera, Hector Ramirez+3 more
core +4 more sources