Results 131 to 140 of about 92,761 (280)
Advanced Science, EarlyView.This review presents a process‐oriented framework for vascularized cardiac tissue engineering, highlighting how the coordinated design of cells, biomaterials, and biofabrication strategies enables the functional development or vascularized myocardium for disease modelling and drug discovery.
Yang Liu +9 more
wiley +1 more source
AIChE Journal, EarlyView.Abstract This work presents the optimization of cell cultivation for monoclonal antibody (mAb) production. We developed a hybrid model describing the effects of multiple process variables on antibody productivity and impurity generation. An automated platform with 12 × 250 mL bioreactors was set up.
Kosuke Nemoto +6 more
wiley +1 more source
Review on New Techniques in Tropane Alkaloids Production
Journal of Medicinal Plants, 2010 Increasing from day to day tendency of human societies to plant based drug usage increased demand of secondary metabolite application. Although artificial production of these compounds greatly progressed, but the only way to achieve these fine medicinal ...
E Dehghan +5 more
doaj
Market Strategies for a Tobacco Bio-Pharming Application: The Case of Gaucher's Disease Treatment [PDF]
Small firms developing biotechnology applications often focus on establishing intellectual property rights, which can then be sold to more established firms with existing market chains. This paper explores the expected 'Buyout' price and economic surplus
Kostandini, Genti, Mills, Bradford F.
core +1 more source
AIChE Journal, EarlyView.Abstract Filamentous microorganisms exhibit complex morphologies that influence product formation and are affected by various bioprocess parameters. Consistent morphology is therefore essential for comparable results during scale‐up. This study investigates the scale‐up of Streptomyces species (Streptomyces spp.) cultivations from shake flasks to ...
Gesa Brauneck +12 more
wiley +1 more source
Production of Biologically-Active Proteins in Plants
Journal of Medicinal Plants, 2006 Plants as bioreactors are able to produce substances including proteins. In order to produce a protein, the corresponding gen is introduced into plant cells by two systems: stable genetic transformation and the use of viral vectors.
MR Verdian Rizi +2 more
doaj
Advanced Intelligent Discovery, EarlyView.Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova +4 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.This study provides an introduction to Bayesian optimisation targeted for experimentalists. It explains core concepts, surrogate modelling, and acquisition strategies, and addresses common real‐world challenges such as noise, constraints, mixed variables, scalability, and automation.
Chuan He +2 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro +3 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley +1 more source