Results 171 to 180 of about 6,100 (218)
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A new biorelevant dissolution method for orodispersible films
European Journal of Pharmaceutics and Biopharmaceutics, 2016Specific knowledge about the dissolution behavior under biorelevant conditions is of high interest for the rational development of orodispersible films (ODFs). As the conditions in the oral cavity strongly differ from those in the gastrointestinal tract and from those performed with the pharmacopoeial test setups, a biorelevant dissolution setup was ...
Jörg Breitkreutz
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Sources of dissolution variability into biorelevant media
International Journal of Pharmaceutics, 2022Identifying sources of dissolution variation is often challenging. Biorelevant dissolution media are compositionally complex, can require multiple steps to fabricate, and are utilized across differing laboratories. The objective was to determine the contributions of location, operator, media fabrication method, day, and tablet to total dissolution ...
Raqeeb, Jamil, James E, Polli
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Biorelevant in-vitro performance testing of orally administered dosage forms
Journal of Pharmacy and Pharmacology, 2012 Abstract Objectives This review focuses on the evolution and current status of biorelevant media and hydrodynamics, and discusses the usefulness of biorelevant performance testing in the evaluation of specific dosage form related lumenal processes. Key
Christos Reppas, Maria Vertzoni
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Microwave Assisted Synthesis of Biorelevant Benzazoles
Current Medicinal Chemistry, 2018The benzazole scaffolds are present in various therapeutic agents and have been recognized as the essential pharmacophore for diverse biological activities. These have generated interest and necessity to develop efficient synthetic methods of these privileged classes of compounds to generate new therapeutic leads for various diseases.
Kapileswar, Seth +2 more
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Biorelevant characterization of biopolymers
Thermochimica Acta, 2003Abstract Polymeric biomaterials are synthetically derived or modified biological polymers designed for in vivo use or for use in the proximity of biological fluids. As is common in the polymer industry, these polymers are produced in bulk and then shaped for a specific end-use. Characterization of biopolymers has two purposes: 1.
Michael Jaffe, Zohar Ophir, Vaishali Pai
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Electrochemical Studies on Some Biorelevant Sulphonamide Azomethines
Materials Today: Proceedings, 2020Abstract Series of synthesized 4-[({2-hydroxy-5-[2-(substituted methyl phenyl) diazen-1-yl] phenyl} methylidine) amino] N-(1,3-thiazol-2 yl)/ 4-amino-N-(5-methyl-1,2-oxazol -3-yl) benzene-1-sulphonamides schiff base derivatives were analysed for their voltammetric behaviour on dropping mercury (DME) and solid electrodes using differential pulse ...
R. Kathal, R. Jain, AK. Halve
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Understanding the interaction between Soluplus® and biorelevant media components
Colloids and Surfaces B: Biointerfaces, 2020Soluplus® (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) is a solubilizing copolymer commonly applied as carrier in solid dispersions of poorly soluble drugs. This polymer is used to increase the apparent solubility of drugs with low aqueous solubility and consequently enhance drug absorption by the human gastrointestinal
Juliana Munari Oliveira Pinto +5 more
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Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study
Molecular Pharmaceutics, 2017Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with these methods.
James Mann +2 more
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Dissolution of solid lipid extrudates in biorelevant media
International Journal of Pharmaceutics, 2012Solid lipid extrudates with the model drug praziquantel were produced with chemically diverse lipids and investigated regarding their dissolution behaviour in different media. The lipids used in this study were glyceryl tripalmitate, glyceryl dibehenate, glyceryl monostearate, cetyl palmitate and solid paraffin.
R, Witzleb +4 more
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Molecular Bottlebrushes for Biorelevant Applications
2023This thesis focuses on the synthesis and applications of hydrophilic polymers with advanced architectures. Chapter 1 introduces molecular bottlebrushes (MBs) in context of their synthesis, properties, and applications in biomedicine. The chapter aims to provide fundamental knowledge and state-of-the-art of research on MBs in biorelevant applications ...
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