Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution [PDF]
Pharmaceutics, 2022 Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharmacopoeial ...
Thomas Eason +4 more
doaj +9 more sources
Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media [PDF]
Pharmaceutics, 2022 Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance ...
Miao Zhang +6 more
doaj +5 more sources
MPTHub: An Open-Source Software for Characterizing the Transport of Particles in Biorelevant Media [PDF]
Nanomaterials, 2022 The study of particle transport in different environments plays an essential role in understanding interactions with humans and other living organisms.
Leandro Gabriel +4 more
doaj +6 more sources
Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media [PDF]
Pharmaceutics, 2022 The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of ...
Dong Ye +9 more
doaj +3 more sources
Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations [PDF]
BMC Biotechnology, 2023 Background Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients.
Ramzi Shawahna +5 more
doaj +3 more sources
Metabolic Stability of D-Allulose in Biorelevant Media and Hepatocytes: Comparison with Fructose and Erythritol [PDF]
Foods, 2019 D-allulose, a C-3 epimer of D-fructose, is a rare monosaccharide used as a food ingredient or a sweetener. In the present study, the in vitro metabolic stability of D-allulose was examined in biorelevant media, that is, simulated gastric fluid (SGF) and ...
Han-Joo Maeng +8 more
doaj +5 more sources
Mechanistic Investigation into the Phase Separation Behavior of Soluplus in the Presence of Biorelevant Media. [PDF]
Mol PharmMore than a decade since its introduction, the polymeric excipient Soluplus continues to receive considerable attention for its application in the development of amorphous solid dispersions (ASDs) and its utility as a solubilizer for drugs exhibiting solubility limited absorption.
Lange JJ +8 more
europepmc +5 more sources
Nanostructured Lipid Carriers as Physicochemical Modulators of Complex Natural Extracts: Release Behavior and Bile-Induced Remodeling in Biorelevant Media [PDF]
MoleculesPropolis is a chemically complex natural product with recognized antioxidant potential, but its compositional heterogeneity and poor aqueous solubility complicate formulation and interpretation of in vitro release behavior.
Javiera Carrasco-Rojas +6 more
doaj +2 more sources
Cocrystal Solubilization in Biorelevant Media and its Prediction from Drug Solubilization. [PDF]
J Pharm Sci, 2015 This work examines cocrystal solubility in biorelevant media (FeSSIF, fed-state simulated intestinal fluid), and develops a theoretical framework that allows for the simple and quantitative prediction of cocrystal solubilization from drug solubilization.
Lipert MP +3 more
europepmc +4 more sources
The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug [PDF]
AAPS Journal, 2010 Simulation of gastrointestinal conditions is essential to adequately predict the in vivo behavior of drug formulations. To reduce the size and number of human studies required to identify a drug product with appropriate performance in both the fed and fasted states, it is advantageous to be able to pre-screen formulations in vitro.
Sandra Klein
exaly +3 more sources