Results 1 to 10 of about 4,013 (240)

MPTHub: An Open-Source Software for Characterizing the Transport of Particles in Biorelevant Media [PDF]

Nanomaterials, 2022
The study of particle transport in different environments plays an essential role in understanding interactions with humans and other living organisms.
Leandro Gabriel, Helena Almeida, Marta Avelar, Bruno Sarmento, José das Neves   +4 more
doaj   +7 more sources

Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media [PDF]

Pharmaceutics, 2022
The poor solubility and permeability of compounds beyond Lipinski’s Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of ...
Dong Ye, Álvaro López Mármol, Verena Lenz, Patricia Muschong, Anita Wilhelm-Alkubaisi, Manuel Weinheimer, Mirko Koziolek, Kerstin A. Sauer, Loic Laplanche, Mario Mezler   +9 more
doaj   +4 more sources

Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations [PDF]

BMC Biotechnology, 2023
Background Lamotrigine is an effective antiseizure medication that can be used in the management of focal and generalized epilepsies in pediatric patients.
Ramzi Shawahna, Hala Saba’aneh, Amal Daraghmeh, Yara Qassarwi, Valentina Franco, Xavier Declèves   +5 more
doaj   +4 more sources

Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media [PDF]

Pharmaceutics, 2022
Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance ...
Miao Zhang, Bin Wu, Shudong Zhang, Lin Wang, Qin Hu, Dongyang Liu, Xijing Chen   +6 more
doaj   +4 more sources

Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution [PDF]

Pharmaceutics, 2022
Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharmacopoeial ...
Thomas Eason, Gisela Ramirez, Andrew J. Clulow, Malinda Salim, Ben J. Boyd   +4 more
doaj   +4 more sources

Mechanistic Investigation into the Phase Separation Behavior of Soluplus in the Presence of Biorelevant Media. [PDF]

Mol Pharm
More than a decade since its introduction, the polymeric excipient Soluplus continues to receive considerable attention for its application in the development of amorphous solid dispersions (ASDs) and its utility as a solubilizer for drugs exhibiting solubility limited absorption.
Lange JJ, Senniksen MB, Wyttenbach N, Page S, Bateman LM, O'Dwyer PJ, Saal W, Kuentz M, Griffin BT.   +8 more
europepmc   +7 more sources

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media [PDF]

Pharmaceutics, 2020
The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine.
Alexandra Teleki, Olivia Nylander, Christel A.S. Bergström   +2 more
doaj   +7 more sources

Cocrystal Solubilization in Biorelevant Media and its Prediction from Drug Solubilization. [PDF]

J Pharm Sci, 2015
This work examines cocrystal solubility in biorelevant media (FeSSIF, fed-state simulated intestinal fluid), and develops a theoretical framework that allows for the simple and quantitative prediction of cocrystal solubilization from drug solubilization.
Lipert MP, Roy L, Childs SL, Rodríguez-Hornedo N.   +3 more
europepmc   +6 more sources

Development and Characterization of a New Oral Antileishmanial Bis(pyridine-2-Carboxamidine) Drug Through Innovative Dissolution Testing in Biorelevant Media Combined with Pharmacokinetic Studies [PDF]

Pharmaceutics
Background/Objectives: Currently there are very few effective oral antileishmanial treatments. In this study we evaluated a new bis(pyridine-2-carboxamidine) antileishmanial drug (JNII40_base) and its hydrochloride salt (JNII40_HCl).
Almudena Laguna, Borja Martínez-Alonso, Víctor Guarnizo-Herrero, J. Jonathan Nué-Martinez, Christophe Dardonville, Santiago Torrado-Santiago, Carlos Torrado-Salmerón   +6 more
doaj   +4 more sources

Nanostructured Lipid Carriers as Physicochemical Modulators of Complex Natural Extracts: Release Behavior and Bile-Induced Remodeling in Biorelevant Media [PDF]

Molecules
Propolis is a chemically complex natural product with recognized antioxidant potential, but its compositional heterogeneity and poor aqueous solubility complicate formulation and interpretation of in vitro release behavior.
Javiera Carrasco-Rojas, Javiera Solas-Soto, Rubén Veas-Albornoz, Carlos F. Lagos, Mario J. Simirgiotis, Francisco Arriagada, Andrea C. Ortiz   +6 more
doaj   +2 more sources