Results 21 to 30 of about 17,248,582 (189)
Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability
British Journal of Pharmacy, 2023 The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically ...
Erin Seonaid Campbell +5 more
doaj +1 more source
A Combined Experimental and Predictive Modeling Study of Diltiazem Release From Natural Polymer Microcapsules in Different Media. [PDF]
CPT Pharmacometrics Syst PharmacolA mechanistic sublingual absorption model was developed by integrating in vitro release kinetics of diltiazem‐loaded microcapsules with a SimBiology‐based two‐compartment model, enabling simulation of in vivo performance across physiologically relevant pH variability scenarios.
Üstün Z, Kara Ü.
europepmc +2 more sources
Pharmaceuticals, 2022 Herein, a simple and rapid HPLC method for the determination of paracetamol milk-containing biorelevant media is proposed. The separation of the analyte from the milk-containing biorelevant media was accomplished isocratically using a mobile phase ...
Natalia Manousi +4 more
doaj +1 more source
Pharmaceutics, 2022 The aim of this study was to understand drug solubilization as a function of age and identify drugs at risk of altered drug solubility in newborns and young infants in comparison to adults.
Mariana Guimarães +4 more
doaj +1 more source
Remote Activation of Hollow Nanoreactors for Heterogeneous Photocatalysis in Biorelevant Media [PDF]
Nano Letters, 2020 Major current challenges in nano-biotechnology and nano-biomedicine include the implementation of predesigned chemical reactions in biological environments. In this context, heterogeneous catalysis is emerging as a promising approach to extend the richness of organic chemistry onto the complex environments inherent to living systems.
Ana Sousa-Castillo +9 more
openaire +6 more sources
, 2022 Dissolution is a key step in the uptake of oral drugs. In order to compare the behaviour of the dissolution of two formulations, the dissolution profile test was used. This assay must be discriminative and should mimic in vivo conditions.
Rocha, Helvécio Vinícius Antunes +2 more
core +2 more sources
British Journal of Pharmacy, 2023 The extent of absorption of orally administered drugs depends on their solubility in human intestinal fluid (HIF). Simulated intestinal fluid is used as biorelevant media to determine drug solubility in vitro.
Rana Tamimi +4 more
doaj +1 more source
Pharmaceutics, 2021 Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins +2 more
doaj +1 more source
In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
Pharmaceutics, 2022 In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models.
Tim Becker +16 more
doaj +1 more source
Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds? [PDF]
, 2013 In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Taupitz, Thomas, Klein, Sandra
core +1 more source