Results 21 to 30 of about 4,013 (240)
Dissolution and precipitation behavior of ternary solid dispersions of ezetimibe in biorelevant media [PDF]
Drug Development and Industrial Pharmacy, 2016 The effects of different formulations and processes on inducing and maintaining the supersaturation of ternary solid dispersions of ezetimibe (EZ) in two biorelevant media fasted-state simulated intestinal fluid (FaSSIF) and fasted-state simulated gastric fluid (FaSSGF) at different temperatures (25 °C and 37 °C) were investigated in this work. Ternary
Amani Alhayali +2 more
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Biorelevant dissolution media as a predictive tool for glyburide a class II drug
European Journal of Pharmaceutical Sciences, 2006 The purpose of this study was to predict the oral absorption of glyburide. Biorelevant dissolution methods, combined with permeability measurements and computational simulations, were used to predict the oral absorption of glyburide. The objective was to establish in vitro/in vivo correlations (IVIVCs) based on the biopharmaceutics drug classification ...
Wei, Hai, Löbenberg, Raimar
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Simplified Biorelevant Media for Screening Dissolution Performance of Poorly Soluble Drugs
Dissolution Technologies, 2007 8 INTRODUCTION Simulation of gastrointestinal conditions is essential to adequately predict the in vivo behavior of poorly soluble drugs. Simulating small intestinal conditions with biorelevant media such as fasted state simulated intestinal fluid (FaSSIF) and fed state simulated intestinal fluid (FeSSIF) has become standard practice in many ...
Thomas Zoeller, Sandra Klein
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The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little [PDF]
International Journal of Pharmaceutics: XFluid co-administered with oral medication directly affects its behaviour. Often, people use fluids other than water when taking their medications. Capsules (mainly gelatine- and HPMC-based) are widely used solid oral dosage forms.
Dorota Sarwinska +11 more
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Разработка и регистрация лекарственных средств, 2019 The results of Indomethacin release from the oral drug delivery systems based on interpolymer complexes with Eudragit® copolymers are presented.
A. V. Sitenkova (Bukhovets) +2 more
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The investigation of kinetics dissolution of prolonged indapamide drugs in biorelevant media
Сеченовский вестник, 2013 In the current work there was performed the development of the method of determination dissolution kinetics in biorelevant media of slightly soluble substance, for example indapamide. The method was validated in terms of specificity, linearity, precision,
E. Yu. Sannikova +3 more
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Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability
British Journal of Pharmacy, 2023 The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically ...
Erin Seonaid Campbell +5 more
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Pharmaceuticals, 2022 Herein, a simple and rapid HPLC method for the determination of paracetamol milk-containing biorelevant media is proposed. The separation of the analyte from the milk-containing biorelevant media was accomplished isocratically using a mobile phase ...
Natalia Manousi +4 more
doaj +1 more source
Pharmaceutics, 2022 The aim of this study was to understand drug solubilization as a function of age and identify drugs at risk of altered drug solubility in newborns and young infants in comparison to adults.
Mariana Guimarães +4 more
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Remote Activation of Hollow Nanoreactors for Heterogeneous Photocatalysis in Biorelevant Media [PDF]
Nano Letters, 2020 Major current challenges in nano-biotechnology and nano-biomedicine include the implementation of predesigned chemical reactions in biological environments. In this context, heterogeneous catalysis is emerging as a promising approach to extend the richness of organic chemistry onto the complex environments inherent to living systems.
Ana Sousa-Castillo +9 more
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