Results 21 to 30 of about 1,404 (160)
Mechanisms of drug solubilization by polar lipids in biorelevant media
European Journal of Pharmaceutical Sciences, 2020 Despite the widespread use of lipid excipients in both academic research and oral formulation development, rational selection guidelines are still missing. In the current study, we aimed to establish a link between the molecular structure of commonly used polar lipids and drug solubilization in biorelevant media. The solubilization of fenofibrate by 13
Vladimir Katev +2 more
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British Journal of Pharmacy, 2023 The extent of absorption of orally administered drugs depends on their solubility in human intestinal fluid (HIF). Simulated intestinal fluid is used as biorelevant media to determine drug solubility in vitro.
Rana Tamimi +4 more
doaj +1 more source
Pharmaceutics, 2021 Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins +2 more
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In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
Pharmaceutics, 2022 In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models.
Tim Becker +16 more
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Biorelevant dissolution of candesartan cilexetil
ADMET and DMPK, 2017 The choice of an appropriate medium for dissolution tests is an essential step during a dosage form development. The adequate design of dissolution testing enables forecasting in vivo behavior of drug formulation.
Lucie Gruberová, Bohumil Kratochvil
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Optically induced electrothermal microfluidic tweezers in bio-relevant media
Scientific Reports, 2023 Non-contact micro-manipulation tools have enabled invasion-free studies of fragile synthetic particles and biological cells. Rapid electrokinetic patterning (REP) traps target particles/cells, suspended in an electrolyte, on an electrode surface.
Kshitiz Gupta +5 more
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Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions
Pharmaceutics, 2022 The aim of this study was to compare the performance of two amorphous formulation strategies: mesoporous silica via solvent impregnation, and solid dispersions by spray drying. Poorly soluble fenofibrate was chosen as the model drug compound.
Hongwei Zhang +5 more
doaj +1 more source
Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements
Separations, 2019 A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure.
Samantha L. Bowerbank +2 more
doaj +1 more source
Química Nova, 2010 An analytical method by liquid chromatography has been proposed and validated to study the apparent solubility of ibuprofen in biorelevant dissolution media.
Sandra M. Gómez +2 more
doaj +1 more source
Dissolution and precipitation behavior of ternary solid dispersions of ezetimibe in biorelevant media [PDF]
Drug Development and Industrial Pharmacy, 2016 The effects of different formulations and processes on inducing and maintaining the supersaturation of ternary solid dispersions of ezetimibe (EZ) in two biorelevant media fasted-state simulated intestinal fluid (FaSSIF) and fasted-state simulated gastric fluid (FaSSGF) at different temperatures (25 °C and 37 °C) were investigated in this work. Ternary
Amani, Alhayali +2 more
openaire +2 more sources