Results 31 to 40 of about 1,404 (160)

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character

Pharmaceutics, 2023
Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioavailability ...
Dóra Csicsák, Rita Szolláth, Szabina Kádár, Rita Ambrus, Csilla Bartos, Emese Balogh, István Antal, István Köteles, Petra Tőzsér, Vivien Bárdos, Péter Horváth, Enikő Borbás, Krisztina Takács-Novák, Bálint Sinkó, Gergely Völgyi   +14 more
doaj   +1 more source

Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

British Journal of Pharmacy, 2022
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde).
Connor O'Farrell, Konstantinos Stamatopoulos , Mark J. H. Simmons, Hannah Batchelor   +3 more
doaj   +1 more source

Development and Validation of a Robust and Efficient HPLC Method for the Simultaneous Quantification of Levodopa, Carbidopa, Benserazide and Entacapone in Complex Matrices

Journal of Pharmacy & Pharmaceutical Sciences, 2017
Purpose: A variety of fixed-dose combination products is used in the therapy of Parkinson Disease. However, to date a proper analytical method applicable for comparative screening of different antiparkinson products was not available.
Erik Wollmer, Sandra Klein
doaj   +1 more source

Supporting food effect prediction using biorelevant small scale in vitro solubility approaches

British Journal of Pharmacy, 2023
This study applies biorelevant fasted and fed simulated intestinal media (SIM) to compare the solubility of griseofulvin, ibuprofen, and dipyridamole to investigate the prediction of food effects.
Maria Ines Silva , Qamar Abuhassan, Kate Pyper, Ibrahim Khadra, Gavin Halbert   +4 more
doaj   +1 more source

Dithioketal Polymers Via Radical Polymerization of γ‐Dithiobutyrolactone

Angewandte Chemie, Volume 138, Issue 21, 18 May 2026.
γ‐Dithiobutyrolactone (DTBL) behaves like a ring‐retaining monomer in radical copolymerization with a series of conjugated monomers like styrene, t‐butyl acrylate and N,N‐dimethylacrylamide. The resulting copolymers contain controlled fractions of dithioketal linkages in their backbone, allowing chemical degradation.
Maksym Odnoroh, Oleksandr Ivanchenko, Asja A. Kroeger, Michelle L. Coote, Stéphane Mazières, Mathias Destarac   +5 more
wiley   +2 more sources

Biorelevant Media Slows the Solution-Mediated Phase Transformation of Amorphous Spironolactone [PDF]

Journal of Pharmaceutical Sciences, 2018
Solution-mediated phase transformation (SMPT) can reduce the high drug concentration expected from amorphous formulations, eliminating the improvement in drug absorption one hoped to gain from this high energy drug state. The differences in SMPT of a supersaturating system were compared in biorelevant media (fasted state simulated intestinal fluid and ...
Mary S, Kleppe, Roy J, Haskell, Robin H, Bogner   +2 more
openaire   +2 more sources

Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms

Pharmaceutics, 2020
We have previously reported that heated powder mixtures of ibuprofen (IBU) and high surface area nanocellulose exhibit an enhanced dissolution and solubility of the drug due to IBU amorphization.
Athanasios Mantas, Marie-Amélie Petit, Albert Mihranyan   +2 more
doaj   +1 more source

Biopharmaceutical Trials of a Dosage Form, which Contain Methionine and Turmeric Extract (Curcuma longa L.)

Разработка и регистрация лекарственных средств, 2021
Introduction. The presence of biologically active substances in the extract from the roots of turmeric extract (Curcuma longa L.) makes it reasonable and makes it possible to predict their effectiveness in pathological conditions caused by oxidative ...
O. A. Gizinger, A. A. Khisamova
doaj   +1 more source

Integrating In Vitro Biopharmaceutics into Physiologically Based Biopharmaceutic Model (PBBM) to Predict Food Effect of BCS IV Zwitterionic Drug (GSK3640254)

Pharmaceutics, 2023
A strategy followed to integrate in vitro solubility and permeability data into a PBBM model to predict the food effect of a BCS IV zwitterionic drug (GSK3640254) observed in clinical studies is described.
Konstantinos Stamatopoulos, Paola Ferrini, Dung Nguyen, Ying Zhang, James M. Butler, Jon Hall, Nena Mistry   +6 more
doaj   +1 more source