Milk Modulates the Gastrointestinal Stability of Tick-Borne Encephalitis Virus: Implications for Alimentary Transmission. [PDF]
J Med VirolABSTRACT Tick‐borne encephalitis virus (TBEV) can be transmitted alimentarily through contaminated dairy products, yet the mechanisms by which the virus survives the digestive tract remain poorly understood. In this study, we investigated the stability of TBEV in milk under simulated gastrointestinal conditions.
Machacek M +3 more
europepmc +2 more sources
A Reproducible Workflow for Macrophage Membrane Isolation and Nanocore Selection Toward Bioinspired Nanoparticles Targeting Immunologically Cold Tumors. [PDF]
Small MethodsA reproducible workflow is established for isolating macrophage membranes to enable the efficient preparation and characterization of membrane‐coated nanoparticles. By optimizing M2‐like nanovesicle stability and nanocore compatibility, this procedure advances the engineering of macrophage membrane‐coated nanoparticles with improved tumor targeting ...
Peixoto D +6 more
europepmc +2 more sources
Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies [PDF]
Journal of Pharmacy and Pharmacology, 2010 Karen Kleberg +2 more
openalex +3 more sources
British Journal of Pharmacy, 2023 The extent of absorption of orally administered drugs depends on their solubility in human intestinal fluid (HIF). Simulated intestinal fluid is used as biorelevant media to determine drug solubility in vitro.
Rana Tamimi +4 more
doaj +1 more source
Pharmaceutics, 2021 Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins +2 more
doaj +1 more source
In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
Pharmaceutics, 2022 In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models.
Tim Becker +16 more
doaj +1 more source
Biorelevant dissolution of candesartan cilexetil
ADMET and DMPK, 2017 The choice of an appropriate medium for dissolution tests is an essential step during a dosage form development. The adequate design of dissolution testing enables forecasting in vivo behavior of drug formulation.
Lucie Gruberová, Bohumil Kratochvil
doaj +1 more source
Comparative study of the potential of poly(2-ethyl-2-oxazoline) as carrier in the formulation of amorphous solid dispersions of poorly soluble drugs [PDF]
, 2019 Despite the fact that solid dispersions are gaining momentum, the number of polymers that have been used as a carrier during the past 50 years is rather limited.
Boel, Eline +5 more
core +1 more source
Optically induced electrothermal microfluidic tweezers in bio-relevant media
Scientific Reports, 2023 Non-contact micro-manipulation tools have enabled invasion-free studies of fragile synthetic particles and biological cells. Rapid electrokinetic patterning (REP) traps target particles/cells, suspended in an electrolyte, on an electrode surface.
Kshitiz Gupta +5 more
doaj +1 more source
In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica formulation [PDF]
, 2017 Drug release from mesoporous silica systems has been widely investigated in vitro using USP Type II (paddle) dissolution apparatus. However, it is not clear if the observed enhanced in vitro dissolution can forecast drug bioavailability in vivo.
Ahern, Robert J. +7 more
core +1 more source