Mechanistic study of physicochemical and biochemical processes affecting intestinal absorption of the sesquiterpene lactone nobilin from multi-component systems in the Caco-2 model [PDF]
, 2015 The overall aim of this work was to investigate the intestinal absorption of the sesquiterpene lactone nobilin from the flowers of Anthemis nobilis L.
Thormann, U.
core +1 more source
Concentration and Composition Dependent Aggregation of Pluronic- and Poly-(2-Oxazolin)-Efavirenz Formulations in Biorelevant Media [PDF]
, 2021 Interactions of intestinal fluids with polymer excipients, drugs and their formulations are not fully understood. Here, diffusion ordered spectroscopy (DOSY) and nuclear Overhauser effect spectroscopy (NOESY), complemented by cryo-TEM were employed to ...
Lorenz, Meinel +9 more
core +2 more sources
Optically induced electrothermal microfluidic tweezers in bio-relevant media
Scientific Reports, 2023 Non-contact micro-manipulation tools have enabled invasion-free studies of fragile synthetic particles and biological cells. Rapid electrokinetic patterning (REP) traps target particles/cells, suspended in an electrolyte, on an electrode surface.
Kshitiz Gupta +5 more
doaj +1 more source
Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine [PDF]
, 2019 The oral cavity is of great importance to the performance of orally retained formulations, including: orally disintegrating tablets, taste-masked formulations, and buccal/sublingual delivery systems.
Gershkovich, Pavel +6 more
core +1 more source
Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions
Pharmaceutics, 2022 The aim of this study was to compare the performance of two amorphous formulation strategies: mesoporous silica via solvent impregnation, and solid dispersions by spray drying. Poorly soluble fenofibrate was chosen as the model drug compound.
Hongwei Zhang +5 more
doaj +1 more source
Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements
Separations, 2019 A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure.
Samantha L. Bowerbank +2 more
doaj +1 more source
Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Chenel M +6 more
europepmc +2 more sources
Química Nova, 2010 An analytical method by liquid chromatography has been proposed and validated to study the apparent solubility of ibuprofen in biorelevant dissolution media.
Sandra M. Gómez +2 more
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Pharmaceutics, 2023 Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioavailability ...
Dóra Csicsák +14 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho +9 more
wiley +2 more sources