Results 51 to 60 of about 1,404 (160)
Pharmaceutics, 2020 Biphasic dissolution systems achieved good predictability for the in vivo performance of several formulations of poorly water-soluble drugs by characterizing dissolution, precipitation, re-dissolution, and absorption.
Alexander Denninger +3 more
doaj +1 more source
Charge Regulation in Crowded Solutions of a Weak Polyelectrolyte: Steric Interactions
Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.Weak polyelectrolytes (WPE) solvated in biorelevant media and synthetic complex fluids that contain substantial concentrations of macromolecules, molecular assemblies, and nanoparticles are observed to exhibit deviations from the acid–base equilibrium observed in single‐component solutions.
David Attia +2 more
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.Abstract This first‐in‐human study (ClinicalTrials.gov identifier: NCT04472897) evaluated the safety, tolerability, pharmacokinetics, and food effect of single ascending and repeat oral doses of GSK2556286 (GSK286), a novel antitubercular drug candidate with efficacy in animal models of tuberculosis.
Emma Ilsley +9 more
wiley +1 more source
Pharmaceutics, 2020 The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine.
Alexandra Teleki +2 more
doaj +1 more source
ChemBioChem, Volume 27, Issue 8, April 2026.We introduce uracil–triazole–pyrene peptidomimetics whose tunable peptide linkers precisely control light emission, copper binding, and interactions with DNA and RNA. Fine structural adjustments unlock selective biomolecular recognition and striking metal‐ and membrane‐responsive fluorescence, paving the way for a new generation of multifunctional ...
Dijana Pavlović Saftić +2 more
wiley +1 more source
Dissolution Behavior of Flufenamic Acid in Heated Mixtures with Nanocellulose
Molecules, 2020 Flufenamic acid (FFA) is a problem drug that has up to eight different polymorphs and shows poor solubility. Variability in bioavailability has been reported in the past resulting in limited use of FFA in the oral solid dosage form.
Athanasios Mantas, Albert Mihranyan
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Medium‐chain diacylglycerols were incorporated into fully hydrogenated palm kernel oil stearin (FHPKS) to regulate crystallization behavior and melt–dispersion performance. Low DAG levels (5%–10%) promoted β′‐rich crystal networks and improved thermal responsiveness, establishing a structure–property framework for designing functional lipid bases ...
Jun Jin, Mingxuan Fang, Siyu Zhang
wiley +1 more source
Organic and Metallacages for Chemical Sensing: Progress in Water‐Compatible Systems
Advanced Sensor Research, Volume 5, Issue 3, March 2026.Supramolecular cages function as three‐dimensional receptors for selective molecular recognition and sensing, and this review outlines design principles for water‐stable architectures, key analyte‐ and medium‐dependent challenges, recent water‐compatible examples (including polymer‐integrated systems), and future opportunities for cage‐based ...
Rabia Zahid +4 more
wiley +1 more source
Design of a Reconfigurable Microfluidic System Enabled by Magnetic Miniature Robots
Advanced Intelligent Systems, Volume 8, Issue 3, March 2026.Magnetic miniature robots are integrated into microfluidic chips to achieve real‐time reconfiguration. By external magnetic actuation, the robots perform sorting, mixing, flow regulation, and bubble removal on demand. This versatile platform eliminates the need for complex on‐chip hardware and enables adaptive control for biological and chemical ...
Yuanhe Chen +3 more
wiley +1 more source
DISSOLUTION MEDIA USED IN DEVELOPMENT AND QUALITY CONTROL OF DRUGS
Разработка и регистрация лекарственных средств, 2019 The main dissolution media recommended for the Dissolution test in Russia and abroad are represented in the review. Possible applications of biorelevant media and media with surfactants are also shown.
O. V. Druzhininskaya, I. E. Smekhova
doaj