Results 51 to 60 of about 17,248,582 (189)
Precision Chemistry for Protein Lysine Modification
Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley +1 more source
The Melanesian Media Declaration [PDF]
, 2020 We, the participants at the Melanesian Media Freedom representing media from Fiji, Vanuatu, Solomon Islands, Papua New Guinea and West Papua, wish to express concern about growing threats to media freedom in our region and call on members of our industry
Media Freedom Forum, Melanesia
core +1 more source
Pharmaceutics, 2019 Nifedipine (NIF) is a 1,4-dihydropyridine-based calcium channel blocker with poor solubility, whose bioavailability is highly dependent on the type of formulation.
Athanasios Mantas, Albert Mihranyan
doaj +1 more source
FEBS Open Bio, Volume 16, Issue 9, Page 1766-1785, September 2026.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Dithioketal Polymers Via Radical Polymerization of γ‐Dithiobutyrolactone
Angewandte Chemie, Volume 138, Issue 21, 18 May 2026.γ‐Dithiobutyrolactone (DTBL) behaves like a ring‐retaining monomer in radical copolymerization with a series of conjugated monomers like styrene, t‐butyl acrylate and N,N‐dimethylacrylamide. The resulting copolymers contain controlled fractions of dithioketal linkages in their backbone, allowing chemical degradation.
Maksym Odnoroh +5 more
wiley +2 more sources
PharmaceuticsThe increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus.
Friederike Brokmann +2 more
doaj +1 more source
A REVIEW ON DEVELOPMENT OF BIORELEVANT DISSOLUTION MEDIUM [PDF]
, 2014 Dissolution testing is a valuable tool that provides key information about bioavailability or bioequivalency as well as batch to batch consistency of drug.
Bhagat, Nitin B
core +1 more source
Influence of cyclodextrins on loratadine solubility in water and in biorelevant media
Acta Marisiensis. Seria Medica, 2023 Introduction and objectives: Loratadine (LOR) is an antihistaminic drug, classified as BCS class II drug due to its low solubility and high permeability. Cyclodextrins (CD) are cyclic oligosaccharides known to improve solubility of poorly soluble drugs by forming inclusion complexes.
Pocrnić, Marijana, Galić, Nives
openaire
Macromolecular Bioscience, Volume 26, Issue 9, September 2026.Personalized dosage forms engineered via hot‐melt extrusion and FDM 3D‐printing enable the evaluation of novel anti‐Alzheimer's compounds. The study integrates dissolution testing, thermo‐analytical profiling, physico‐chemical characterization, cytotoxicity, and stability to advance personalized medicine in drug development.
Marie Nevyhoštěná +7 more
wiley +1 more source
Compositional effect of complex biorelevant media on the crystallization kinetics of an active pharmaceutical ingredient [PDF]
, 2017 Bile salts are endogenous surfactants present in the human gastrointestinal tract in the form of mixed micelles that also contain phospholipids. Due to the inevitable encounter of oral drug formulations with bile salts, it is important to understand the ...
Lowinger, M. +15 more
core +1 more source