Results 51 to 60 of about 4,013 (240)

A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow [PDF]

, 2016
© 2016 Author(s). The study of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease, has relied largely upon the use of animal or cell culture models; neither of which can represent all aspects of the human pathophysiology ...
A. Dawson, Ananthakrishnan A. N., C. Dyer, Itzkowitz S. H., J. Davies, J. Greenman, J. Macfie, L. Karsai, M. Jacobsen, Ponder A., Rodrigues E., Triantafillidis J. K.   +11 more
core   +1 more source

Dithioketal Polymers Via Radical Polymerization of γ‐Dithiobutyrolactone

Angewandte Chemie, EarlyView.
γ‐Dithiobutyrolactone (DTBL) behaves like a ring‐retaining monomer in radical copolymerization with a series of conjugated monomers like styrene, t‐butyl acrylate and N,N‐dimethylacrylamide. The resulting copolymers contain controlled fractions of dithioketal linkages in their backbone, allowing chemical degradation.
Maksym Odnoroh, Oleksandr Ivanchenko, Asja A. Kroeger, Michelle L. Coote, Stéphane Mazières, Mathias Destarac   +5 more
wiley   +2 more sources

The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character

Pharmaceutics, 2023
Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioavailability ...
Dóra Csicsák, Rita Szolláth, Szabina Kádár, Rita Ambrus, Csilla Bartos, Emese Balogh, István Antal, István Köteles, Petra Tőzsér, Vivien Bárdos, Péter Horváth, Enikő Borbás, Krisztina Takács-Novák, Bálint Sinkó, Gergely Völgyi   +14 more
doaj   +1 more source

Pyrene, a Test Case for Deep-Ultraviolet Molecular Photophysics [PDF]

, 2019
We determined the complete relaxation dynamics of pyrene in ethanol from the second bright state, employing experimental and theoretical broadband heterodyne detected transient grating and two-dimensional photon echo (2DPE) spectroscopy, using pulses ...
Garavelli, M., Giussani, A., Miller, R., Mukamel, S., Nenov, A., Picchiotti, A., Prokhorenko, V.   +6 more
core   +2 more sources

European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children. [PDF]

, 2017
© American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate ...
C Tuleu, Catherine Tuleu, F Liu, F Liu, Fang Liu, H Batchelor, H Batchelor, H Wachtel, Hannah Batchelor, HK Batchelor, J Walsh, J Walsh, J Walsh, J Walsh, J Walsh, Jenny Walsh, M Pein, Roy Turner, S Salunke, S Salunke, S Salunke, S Salunke, S Salunke, S Salunke, Smita Salunke, T Nunn, T Sam, TB Ernest, Tzuchi Rob Ju   +28 more
core   +4 more sources

Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

British Journal of Pharmacy, 2022
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde).
Connor O'Farrell, Konstantinos Stamatopoulos , Mark J. H. Simmons, Hannah Batchelor   +3 more
doaj   +1 more source

Development and Validation of a Robust and Efficient HPLC Method for the Simultaneous Quantification of Levodopa, Carbidopa, Benserazide and Entacapone in Complex Matrices

Journal of Pharmacy & Pharmaceutical Sciences, 2017
Purpose: A variety of fixed-dose combination products is used in the therapy of Parkinson Disease. However, to date a proper analytical method applicable for comparative screening of different antiparkinson products was not available.
Erik Wollmer, Sandra Klein
doaj   +1 more source

Supporting food effect prediction using biorelevant small scale in vitro solubility approaches

British Journal of Pharmacy, 2023
This study applies biorelevant fasted and fed simulated intestinal media (SIM) to compare the solubility of griseofulvin, ibuprofen, and dipyridamole to investigate the prediction of food effects.
Maria Ines Silva , Qamar Abuhassan, Kate Pyper, Ibrahim Khadra, Gavin Halbert   +4 more
doaj   +1 more source

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release [PDF]

, 2014
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to im-prove their
Allemandi, Daniel Alberto, Castro, Silvina Gabriela, González Vidal, Noelia Luján, Palma, Santiago Daniel, Sanchez Bruni, Sergio Fabian   +4 more
core   +1 more source

Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms

Pharmaceutics, 2020
We have previously reported that heated powder mixtures of ibuprofen (IBU) and high surface area nanocellulose exhibit an enhanced dissolution and solubility of the drug due to IBU amorphization.
Athanasios Mantas, Marie-Amélie Petit, Albert Mihranyan   +2 more
doaj   +1 more source