Results 41 to 50 of about 17,248,582 (189)

Development and Validation of a Robust and Efficient HPLC Method for the Simultaneous Quantification of Levodopa, Carbidopa, Benserazide and Entacapone in Complex Matrices

Journal of Pharmacy & Pharmaceutical Sciences, 2017
Purpose: A variety of fixed-dose combination products is used in the therapy of Parkinson Disease. However, to date a proper analytical method applicable for comparative screening of different antiparkinson products was not available.
Erik Wollmer, Sandra Klein
doaj   +1 more source

Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

British Journal of Pharmacy, 2022
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde).
Connor O'Farrell, Konstantinos Stamatopoulos , Mark J. H. Simmons, Hannah Batchelor   +3 more
doaj   +1 more source

Supporting food effect prediction using biorelevant small scale in vitro solubility approaches

British Journal of Pharmacy, 2023
This study applies biorelevant fasted and fed simulated intestinal media (SIM) to compare the solubility of griseofulvin, ibuprofen, and dipyridamole to investigate the prediction of food effects.
Maria Ines Silva , Qamar Abuhassan, Kate Pyper, Ibrahim Khadra, Gavin Halbert   +4 more
doaj   +1 more source

Dissolution and precipitation behavior of ternary solid dispersions of ezetimibe in biorelevant media [PDF]

Drug Development and Industrial Pharmacy, 2016
The effects of different formulations and processes on inducing and maintaining the supersaturation of ternary solid dispersions of ezetimibe (EZ) in two biorelevant media fasted-state simulated intestinal fluid (FaSSIF) and fasted-state simulated gastric fluid (FaSSGF) at different temperatures (25 °C and 37 °C) were investigated in this work. Ternary
Amani, Alhayali, Staffan, Tavellin, Sitaram, Velaga   +2 more
openaire   +2 more sources

Biorelevant Media Slows the Solution-Mediated Phase Transformation of Amorphous Spironolactone [PDF]

Journal of Pharmaceutical Sciences, 2018
Solution-mediated phase transformation (SMPT) can reduce the high drug concentration expected from amorphous formulations, eliminating the improvement in drug absorption one hoped to gain from this high energy drug state. The differences in SMPT of a supersaturating system were compared in biorelevant media (fasted state simulated intestinal fluid and ...
Mary S, Kleppe, Roy J, Haskell, Robin H, Bogner   +2 more
openaire   +2 more sources

Biopharmaceutical Trials of a Dosage Form, which Contain Methionine and Turmeric Extract (Curcuma longa L.)

Разработка и регистрация лекарственных средств, 2021
Introduction. The presence of biologically active substances in the extract from the roots of turmeric extract (Curcuma longa L.) makes it reasonable and makes it possible to predict their effectiveness in pathological conditions caused by oxidative ...
O. A. Gizinger, A. A. Khisamova
doaj   +1 more source

Directly Compressed Tablets of Free Acid Ibuprofen with Nanocellulose Featuring Enhanced Dissolution: A Side-by-Side Comparison with Commercial Oral Dosage Forms

Pharmaceutics, 2020
We have previously reported that heated powder mixtures of ibuprofen (IBU) and high surface area nanocellulose exhibit an enhanced dissolution and solubility of the drug due to IBU amorphization.
Athanasios Mantas, Marie-Amélie Petit, Albert Mihranyan   +2 more
doaj   +1 more source

Integrating In Vitro Biopharmaceutics into Physiologically Based Biopharmaceutic Model (PBBM) to Predict Food Effect of BCS IV Zwitterionic Drug (GSK3640254)

Pharmaceutics, 2023
A strategy followed to integrate in vitro solubility and permeability data into a PBBM model to predict the food effect of a BCS IV zwitterionic drug (GSK3640254) observed in clinical studies is described.
Konstantinos Stamatopoulos, Paola Ferrini, Dung Nguyen, Ying Zhang, James M. Butler, Jon Hall, Nena Mistry   +6 more
doaj   +1 more source

Expanding the Scope of 1,2‐Diazepines Through Alternative Activation Strategies

European Journal of Organic Chemistry, Volume 29, Issue 35, 19 September 2026.
Often overlooked due to tedious synthetic routes, 1,2‐diazepines can be found in handful of biorelevant molecules. Previous reports from our group lifted the principal synthetic lock: a rapid and user‐friendly protocol to reach monocyclic 1,2‐diazepines from readily available pyridines and electrophilic activating groups. Herein, we extend the scope of
Alexis Leblais, Diego Robles, Aurélie Damond, Xavier Moreau, Clément Ghiazza   +4 more
wiley   +1 more source

Integration of Biorelevant Pediatric Dissolution Methodology into PBPK Modeling to Predict In Vivo Performance and Bioequivalence of Generic Drugs in Pediatric Populations:a Carbamazepine Case Study [PDF]

, 2023
This study investigated the impact of gastro-intestinal fluid volume and bile salt (BS) concentration on the dissolution of carbamazepine (CBZ) immediate release (IR) 100 mg tablets and to integrate these in vitro biorelevant dissolution profiles into ...
Lanyan Fang, Pawar, Gopal, Burckart, Gilbert J., Al Shoyaib, Abdullah, Gilbert J. Burckart, Abdullah Al Shoyaib, Hannah K. Batchelor, Liang Zhao, Kairui Feng, Batchelor, Hannah K., Youssef M. Mousa, Jones, Marie-Christine, Gopal Pawar, Zhao, Liang, Jones, Marie-Christine; id_orcid, Marie-Christine Jones, Feng, Kairui, Mousa, Youssef M., Fang, Lanyan, Fang Wu, Wu, Fang   +20 more
core   +1 more source