Biopharmaceutical classification of poorly soluble drugs with respect to “enabling formulations” [PDF]
, 2013 The large number of drug candidates with poor dissolution characteristics seen in the past decade, has fostered interest in so-called "enabling formulations", i.e., formulations which shall make such drugs bio-available.
Brandl, Martin +3 more
core +1 more source
Biorelevant Media Slows the Solution-Mediated Phase Transformation of Amorphous Spironolactone [PDF]
Journal of Pharmaceutical Sciences, 2018 Solution-mediated phase transformation (SMPT) can reduce the high drug concentration expected from amorphous formulations, eliminating the improvement in drug absorption one hoped to gain from this high energy drug state. The differences in SMPT of a supersaturating system were compared in biorelevant media (fasted state simulated intestinal fluid and ...
Mary S, Kleppe +2 more
openaire +2 more sources
Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions
Pharmaceutics, 2022 The aim of this study was to compare the performance of two amorphous formulation strategies: mesoporous silica via solvent impregnation, and solid dispersions by spray drying. Poorly soluble fenofibrate was chosen as the model drug compound.
Hongwei Zhang +5 more
doaj +1 more source
Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]
, 2019 Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair +57 more
core +2 more sources
3D printing of medicines: Engineering novel oral devices with unique design and drug release characteristics [PDF]
, 2015 YesThree dimensional printing (3DP) was used to engineer novel oral drug delivery devices, with specialised design configurations loaded with multiple actives, with applications in personalised medicine.
Abdul W. Basit +7 more
core +1 more source
Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements
Separations, 2019 A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure.
Samantha L. Bowerbank +2 more
doaj +1 more source
Statistical investigation of the full concentration range of fasted and fed simulated intestinal fluid on the equilibrium solubility of oral drugs [PDF]
, 2018 Upon oral administration the solubility of a drug in intestinal fluid is a key property influencing bioavailability. It is also recognised that simple aqueous solubility does not reflect intestinal solubility and to optimise in vitro investigations ...
Dunn, Claire +5 more
core +1 more source
Development of Mucoadhesive Gel Microbicide to Target Mucosal HIV Reservoirs [PDF]
, 2014 The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready availability and most importantly cost. The aim of this work was to develop affordable microbicide mucoadhesive gel formulation of synthetic anti HIV ...
Shegokar, Ranjita, Singh, Kamalinder K
core +1 more source
Química Nova, 2010 An analytical method by liquid chromatography has been proposed and validated to study the apparent solubility of ibuprofen in biorelevant dissolution media.
Sandra M. Gómez +2 more
doaj +1 more source
Biorelevant drug release of Metformin dosage forms using complementary in vitro tools [PDF]
, 2017 Drug release from immediate release (IR) and extended release (ER) metformin products was investigated using the Dow Chemical Company’s FloVitroTM biorelevant dissolution instrument.
Box, Karl +2 more
core +1 more source