Results 41 to 50 of about 1,404 (160)

Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

Advanced NanoBiomed Research, EarlyView.
Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro, Aldo R. Boccaccini, Nicholas R. Forsyth, Tina P. Dale   +3 more
wiley   +1 more source

Immediate-Release Nifedipine Binary Dry Powder Mixtures with Nanocellulose Featuring Enhanced Solubility and Dissolution Rate

Pharmaceutics, 2019
Nifedipine (NIF) is a 1,4-dihydropyridine-based calcium channel blocker with poor solubility, whose bioavailability is highly dependent on the type of formulation.
Athanasios Mantas, Albert Mihranyan
doaj   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo [PDF]

Biomeditsinskaya Khimiya, 2011
The review deals with the modern tool for modeling of drug behavior in vivo, - the dissolution test in biorelevant media, imitating gastrointestinal fluids. The formulations and preparation methods of fasted state simulation intestinal fluid, FaSSIF and fed state simulation intestinal fluid, FeSSIF, are defined.
G V, Ramenskaia, I E, Shokhin, A Iu, Savchenko, E A, Volkova   +3 more
openaire   +2 more sources

Electrooxidative Iodination of Carbonyl Compounds: A Mild, Simple, and Scalable Access to α‐Iodocarbonyls

ChemElectroChem, Volume 13, Issue 13, 2 July 2026.
The efficient electrochemical synthesis of iodinated carbonyl compounds, valuable building blocks, is reported. The method relies on the controlled generation of electrophilic iodine species from simple and inexpensive iodide salts under mild electrochemical conditions, enabling excellent compatibility with aldehydes bearing sensitive functional groups.
Biswadeep Manna, Nora Deil, Marine Pinaud, Sagar Arepally, Monika Merje Meinberg, Anastasiya Krech, Maksim Ošeka   +6 more
wiley   +1 more source

Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation

Pharmaceutics, 2021
Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
doaj   +1 more source

Bidirectional Photoswitching of a Tailored Azobenzene with Red and Far‐Red Light Involving Triplet Sensitization in an Aqueous System

Advanced Science, Volume 13, Issue 36, 29 June 2026.
The action spectrum of a tailored azobenzene is shifted toward bio‐optical window through the chemical modification of its singlet and triplet energy levels. Consequently, the bidirectional photo‐switching of azobenzene in physiological conditions is achieved when excited by red and far‐red light, which offers greater tissue penetration.
Mila Miroshnichenko, Helen Hölzel, Edvinas Orentas, Karolis Kazlauskas, Pedro Ferreira, Fabienne Dumoulin, Carles Alcaide, Miquel Solà, Roger Bresolí‐Obach, Santi Nonell, Pankaj Bharmoria, Kasper Moth‐Poulsen   +11 more
wiley   +1 more source

Influence of cyclodextrins on loratadine solubility in water and in biorelevant media

Acta Marisiensis. Seria Medica, 2023
Introduction and objectives: Loratadine (LOR) is an antihistaminic drug, classified as BCS class II drug due to its low solubility and high permeability. Cyclodextrins (CD) are cyclic oligosaccharides known to improve solubility of poorly soluble drugs by forming inclusion complexes.
Pocrnić, Marijana, Galić, Nives
openaire  

Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption

Pharmaceutics, 2019
Drug absorption across viable porcine intestines was investigated using an Ussing chamber system. The apparent permeability coefficients, Papp,pig, were compared to the permeability coefficients determined in humans in vivo, Peff,human. Eleven drugs from
Yvonne E. Arnold, Julien Thorens, Stéphane Bernard, Yogeshvar N. Kalia   +3 more
doaj   +1 more source

Potential of Covalent Organic Framework in Pharmacy and Biomedicine: Influence of Structure on Properties and Applications

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
From modular COF design to biomedical translation, this Review maps how linkage chemistry, topology, pore environment, and particle engineering govern bioperformance, therapeutic and diagnostic function, safety, and clinical readiness. Covalent organic frameworks (COFs) are a versatile class of crystalline porous materials with growing potential in ...
Julia Kolodziejczyk, Marta E. Plonska‐Brzezinska   +1 more
wiley   +1 more source