Results 61 to 70 of about 1,404 (160)

Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Brazilian Journal of Pharmaceutical Sciences, 2015
USP Apparatus 3 (reciprocating cylinder) is a very versatile device for the in vitro assessment of release characteristics of solid oral dosage forms, because it enables the product to be subjected to different dissolution media and agitation speeds in a
Bianca Ramos Pezzini, Michele Georges Issa, Marcelo Dutra Duque, Humberto Gomes Ferraz   +3 more
doaj   +1 more source

Characterization of biosurfactants’ micelles formation using fluorescence measurements: sodium taurocholate as case of study

ADMET and DMPK
Background and purpose: The evaluation of micellization parameters of surfactants that aggregate gradually, such as bile salts, is not trivial. In this work, different probes and data treatment models are tested to set up an analytical method based on ...
Susana Amézqueta, Elisabet Fuguet, Rubén Cabañas, Clara Ràfols   +3 more
doaj   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

THE FEATURES OF THE PREDICTIVE DISSOLUTION TESTING (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Dissolution test plays an important role at different levels of the development and manufacturing drugs as one of the major quality control tools and an integral part of In vitro tests in the study of drug release from the developed dosage forms. Article
R. I. Moustafine, A. V. Sitenkova (Bukhovets), N. Fotaki   +2 more
doaj  

Organic Electrochemical Transistors for Neuromorphic Devices and Applications

Advanced Materials, Volume 38, Issue 9, 12 February 2026.
Organic electrochemical transistors are emerging as promising platforms for neuromorphic devices that emulate neuronal and synaptic activities and can seamlessly integrate with biological systems. This review focuses on resultant organic artificial neurons, synapses, and integrated devices, with an emphasis on their ability to perform neuromorphic ...
Kexin Xiang, Jiajun Song, Hong Liu, Junxin Chen, Feng Yan   +4 more
wiley   +1 more source

Evaluating the Impact of Intestinal Bile Salts on Drug Absorption Using PBPK Modeling: Case Studies With Efavirenz, Cinnarizine, and Posaconazole

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT A high number of poorly soluble compounds are being developed; thus, understanding the factors that influence their absorption is critical. Intestinal bile salts, which facilitate micelle‐mediated solubilization, are particularly important for drugs with low solubility and are reported to be highly variable.
Laura G. Al‐Amiry Santos, Sebastian Polak, Karen Rowland Yeo   +2 more
wiley   +1 more source

Effect of physicochemical properties on the pharmacokinetic parameters of the new representative of benzothiazinones antituberculosis drug macozinonе

Терапевтический архив, 2020
Introduction.Tuberculosis (TB) is one of the top ten causes of death worldwide. Improvement of the treatment options via development of new drugs and treatment regimens that would be more convenient for patients is one of key options of improving the ...
A. L. Khokhlov, A. O. Mariandyshev, V. S. Shcherbakova, I. V. Ozerova, Yu. G. Kazaishvili, O. V. Igumnova, A. A. Bolgarina, B. A. Rudoy   +7 more
doaj   +1 more source

Impact of presence of excipients in drug analysis in fed-state gastric biorelevant media

European Journal of Pharmaceutics and Biopharmaceutics, 2018
In this study, the influence of the presence of excipients in sample preparation and clean-up steps required prior to drug analysis in milk-based media which simulate the in vivo properties of the fed state stomach was investigated. 15 excipients, normally present in solid dosage forms of five APIs tested (atenolol, paracetamol, furosemide, nifedipine ...
Baxevanis, Fotios, Kuiper, Jesse, Fotaki, Nikoletta   +2 more
openaire   +3 more sources

Glutathione-Loaded Solid Lipid Microparticles as Innovative Delivery System for Oral Antioxidant Therapy

Pharmaceutics, 2019
The present study aimed to develop a novel formulation containing glutathione (GSH) as an oral antioxidant therapy for the treatment of oxidative stress-related intestinal diseases.
Serena Bertoni, Beatrice Albertini, Carlotta Facchini, Cecilia Prata, Nadia Passerini   +4 more
doaj   +1 more source

Development of biorelevant media and dissolution tests for gastrointestinal disease states

, 2022
Standard biorelevant media reflect the average gastrointestinal (GI) physiology in healthy volunteers. The use of biorelevant media in in vitro experiments has become an important strategy to predict drug behaviour in vivo and is often combined with in silico tools in order to simulate drug plasma profiles over time.
openaire   +2 more sources