Results 61 to 70 of about 17,248,582 (189)

Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation

open access: yesPharmaceutics, 2021
Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
doaj   +1 more source

The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo [PDF]

open access: yesBiomeditsinskaya Khimiya, 2011
The review deals with the modern tool for modeling of drug behavior in vivo, - the dissolution test in biorelevant media, imitating gastrointestinal fluids. The formulations and preparation methods of fasted state simulation intestinal fluid, FaSSIF and fed state simulation intestinal fluid, FeSSIF, are defined.
G V, Ramenskaia   +3 more
openaire   +2 more sources

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

open access: yesAdvanced Science, Volume 13, Issue 46, 17 August 2026.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu   +5 more
wiley   +1 more source

Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro   +3 more
wiley   +1 more source

Feedback on the proposal for a regulation establishing a common framework for media services in the internal market (European Media Freedom Act) and amending Directive 2010/13/EU [PDF]

open access: yes, 2023
With this contribution, the Centre for Media Pluralism and Media Freedom (CMPF) at the European University Institute offers a feedback to some aspects of the Proposal for a Regulation of the European Parliament and the Council establishing a common ...
Centre for Media Pluralism and Media Freedom
core   +1 more source

BIORELEVANT DISSOLUTION MEDIA: ITS CURRENT STATUS AND FUTUTRE PERSPECTIVES [PDF]

open access: yes
The landscape of dissolution media has been dynamically evolving with newer drugs entering the market among which most of them are either BCS class II or BCS class IV drugs exhibiting poor solubility.
Mehta, Tejal   +2 more
core   +1 more source

A Water‐Soluble Fluorescent 2,5‐bis(arylethynyl)rhodacyclopentadiene for Live‐Cell Imaging and Sensing of DNA, RNA, and Protein (BSA)

open access: yesChemPhotoChem, Volume 10, Issue 8, August 2026.
A water‐soluble and ‐stable 2,5‐bis(arylethynyl)rhodacyclopentadiene fluoresces, with no observable phosphorescence. However, competitive ISC to T1 leads to potent 1O2 sensitization. It binds strongly to DNA, RNA, and protein (BSA); efficiently enters living human cells accumulating preferentially in mitochondrial membranes; and is nontoxic even at ...
Shishir Ghosh   +14 more
wiley   +1 more source

CMPF’s contribution to the call for evidence on the European Media Freedom Act (EMFA) [PDF]

open access: yes, 2022
The European Commission announced in 2021 its will to draft a European Media Freedom Act (EMFA); in January 2022, it opened a public consultation in this regard.
Centre for Media Pluralism and Media Freedom
core   +1 more source

Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption

open access: yesPharmaceutics, 2019
Drug absorption across viable porcine intestines was investigated using an Ussing chamber system. The apparent permeability coefficients, Papp,pig, were compared to the permeability coefficients determined in humans in vivo, Peff,human. Eleven drugs from
Yvonne E. Arnold   +3 more
doaj   +1 more source

A Rational Design of a Biphasic DissolutionSetup—Modelling of Biorelevant Kinetics for a Ritonavir Hot-Melt Extruded Amorphous Solid Dispersion

open access: yesPharmaceutics, 2020
Biphasic dissolution systems achieved good predictability for the in vivo performance of several formulations of poorly water-soluble drugs by characterizing dissolution, precipitation, re-dissolution, and absorption.
Alexander Denninger   +3 more
doaj   +1 more source

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