Results 71 to 80 of about 1,404 (160)

Performing a physiologically relevant test for cladribine tablets

Разработка и регистрация лекарственных средств
Introduction. The introduction of devices – analogues of GIS (hereinafter–- Gastro-intestinal simulator) is one of the current ways to develop in-vitro assessment of the quality of solid dosage forms.
P. A. Losenkova, D. D. Gvozdev, A. V. Suvorova, Yu. V. Medvedev, V. S. Shcherbakova, Yu. G. Kazaishvili, K. Ya. Zaslavskaya, A. M. Poluyanov, I. E. Shohin   +8 more
doaj   +1 more source

Designing an effective dissolution test for bilayer tablets tailored for optimal melatonin release in sleep disorder management

Frontiers in Nutrition
This project aims to investigate the release performance of bilayer tablet (BL-Tablet) designed with both fast and slow-release technology, targeting sleep disorders.
Rebecca Bassetto, Emanuele Amadio, Francesco Ciampanelli, Stefano Perin, Pietro Ilari, Paolo Gaballo, Martina Callegari, Sara Feltrin, Jacopo Gobbo, Samuele Zanatta, Walter Bertin   +10 more
doaj   +1 more source

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Pharmaceutics, 2019
The formulation of arylpropionic acid derivatives (profens), which are poorly soluble Biopharmaceutical Classification System (BCS) Type II drugs, has a strong impact on their therapeutic action.
Athanasios Mantas, Valentine Labbe, Irena Loryan, Albert Mihranyan   +3 more
doaj   +1 more source

Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution

Acta Pharmaceutica, 2014
Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in ...
Stojković Aleksandra, Tajber Lidia, Paluch Krzysztof J., Djurić Zorica, Parojčić Jelena, Corrigan Owen I.   +5 more
doaj   +1 more source

Simplified Biorelevant Media for Screening Dissolution Performance of Poorly Soluble Drugs

Dissolution Technologies, 2007
8 INTRODUCTION Simulation of gastrointestinal conditions is essential to adequately predict the in vivo behavior of poorly soluble drugs. Simulating small intestinal conditions with biorelevant media such as fasted state simulated intestinal fluid (FaSSIF) and fed state simulated intestinal fluid (FeSSIF) has become standard practice in many ...
Thomas Zoeller, Sandra Klein
openaire   +1 more source

A COMPARATIVE STUDY OF DRUG RELEASE FROM POLYCOMPLEX MATRICES IN STANDARD AND BIORELEVANT MEDIA USING USP III AND USP IV APPARATUS

Разработка и регистрация лекарственных средств, 2019
The results of Indomethacin release from the oral drug delivery systems based on interpolymer complexes with Eudragit® copolymers are presented.
A. V. Sitenkova (Bukhovets), N. Fotaki, R. I. Moustafine   +2 more
doaj  

Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range

ADMET and DMPK, 2016
Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility.
Joerg Berghausen, Frank Hans Seiler, Nathalie Gobeau, Bernard Faller   +3 more
doaj   +1 more source

Prediction of In Vitro Drug Dissolution into Fed-state Biorelevant Media: Contributions of Solubility Enhancement and Relatively Low Colloid Diffusivity. [PDF]

Eur J Pharm Sci, 2022
Jamil R, Polli JE.
europepmc   +1 more source

SC Powder – domestic powder for the preparation of biorelevant media from the company Scientific Compliance

Разработка и регистрация лекарственных средств
The use of biorelevant dissolution media makes it possible to reproduce conditions as in the human gastrointestinal tract. This expands the capabilities of laboratories involved in the analysis of solid dosage forms and allows obtaining physiologically ...
article Editorial
doaj  

Solubility of Piperine and Its Inclusion Complexes in Biorelevant Media and Their Effect on Attenuating Mouse Ileum Contractions. [PDF]

ACS Omega, 2021
Ezawa T, Inagaki Y, Kashiwaba K, Matsumoto N, Moteki H, Murata I, Inoue Y, Kimura M, Ogihara M, Kanamoto I.   +9 more
europepmc   +1 more source