Results 71 to 80 of about 4,013 (240)
Pharmaceutics, 2019 Nifedipine (NIF) is a 1,4-dihydropyridine-based calcium channel blocker with poor solubility, whose bioavailability is highly dependent on the type of formulation.
Athanasios Mantas, Albert Mihranyan
doaj +1 more source
The gut in the beaker : missing the surfactants [PDF]
, 2016 Gastrointestinal drug administration is the preferred route for the majority of drugs however, the natural physiology and physicochemistry of the gastrointestinal tract is critical to absorption but complex and influenced by factors such as diet or ...
Halbert, Gavin W. +2 more
core +1 more source
Charge Regulation in Crowded Solutions of a Weak Polyelectrolyte: Steric Interactions
Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.Weak polyelectrolytes (WPE) solvated in biorelevant media and synthetic complex fluids that contain substantial concentrations of macromolecules, molecular assemblies, and nanoparticles are observed to exhibit deviations from the acid–base equilibrium observed in single‐component solutions.
David Attia +2 more
wiley +1 more source
Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation
Pharmaceutics, 2021 Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
doaj +1 more source
Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges [PDF]
, 2016 The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore ...
Al Shafiee, Maen, Kaialy, Waseem
core +1 more source
ChemBioChem, Volume 27, Issue 8, April 2026.We introduce uracil–triazole–pyrene peptidomimetics whose tunable peptide linkers precisely control light emission, copper binding, and interactions with DNA and RNA. Fine structural adjustments unlock selective biomolecular recognition and striking metal‐ and membrane‐responsive fluorescence, paving the way for a new generation of multifunctional ...
Dijana Pavlović Saftić +2 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Medium‐chain diacylglycerols were incorporated into fully hydrogenated palm kernel oil stearin (FHPKS) to regulate crystallization behavior and melt–dispersion performance. Low DAG levels (5%–10%) promoted β′‐rich crystal networks and improved thermal responsiveness, establishing a structure–property framework for designing functional lipid bases ...
Jun Jin, Mingxuan Fang, Siyu Zhang
wiley +1 more source
Pharmaceutics, 2019 Drug absorption across viable porcine intestines was investigated using an Ussing chamber system. The apparent permeability coefficients, Papp,pig, were compared to the permeability coefficients determined in humans in vivo, Peff,human. Eleven drugs from
Yvonne E. Arnold +3 more
doaj +1 more source
Organic and Metallacages for Chemical Sensing: Progress in Water‐Compatible Systems
Advanced Sensor Research, Volume 5, Issue 3, March 2026.Supramolecular cages function as three‐dimensional receptors for selective molecular recognition and sensing, and this review outlines design principles for water‐stable architectures, key analyte‐ and medium‐dependent challenges, recent water‐compatible examples (including polymer‐integrated systems), and future opportunities for cage‐based ...
Rabia Zahid +4 more
wiley +1 more source
Impact of presence of excipients in drug analysis in fed-state gastric biorelevant media [PDF]
European Journal of Pharmaceutics and Biopharmaceutics, 2018 In this study, the influence of the presence of excipients in sample preparation and clean-up steps required prior to drug analysis in milk-based media which simulate the in vivo properties of the fed state stomach was investigated. 15 excipients, normally present in solid dosage forms of five APIs tested (atenolol, paracetamol, furosemide, nifedipine ...
Baxevanis, Fotios +2 more
openaire +2 more sources