Results 91 to 100 of about 4,013 (240)

Evaluating the Impact of Intestinal Bile Salts on Drug Absorption Using PBPK Modeling: Case Studies With Efavirenz, Cinnarizine, and Posaconazole

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT A high number of poorly soluble compounds are being developed; thus, understanding the factors that influence their absorption is critical. Intestinal bile salts, which facilitate micelle‐mediated solubilization, are particularly important for drugs with low solubility and are reported to be highly variable.
Laura G. Al‐Amiry Santos, Sebastian Polak, Karen Rowland Yeo   +2 more
wiley   +1 more source

Effect of Gastric Fluid Volume on the in Vitro Dissolution and in Vivo Absorption of BCS Class II Drugs: A Case Study with Nifedipine [PDF]

, 2016
Nifedipine is a BCS Class II drug used for treatment of hypertension and preterm labor. Large inter-patient variability in nifedipine absorption results in variable exposure among different patients.
Fadda, Hala M., Foster, David R., Nader, Ahmed M., Quinney, Sara K.   +3 more
core   +2 more sources

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Development of biorelevant media and dissolution tests for gastrointestinal disease states

, 2022
Standard biorelevant media reflect the average gastrointestinal (GI) physiology in healthy volunteers. The use of biorelevant media in in vitro experiments has become an important strategy to predict drug behaviour in vivo and is often combined with in silico tools in order to simulate drug plasma profiles over time.
openaire   +3 more sources

New alternatives in photoprotection: Preparation and evaluation of lamellar silicate derivatives and their use as sunscreens

International Journal of Cosmetic Science, Volume 48, Issue 1, Page 172-185, February 2026.
The use of nanotechnology in sunscreens has increased, with various filters and organoclays tested for new intercalated formulations. As animal toxicity tests decrease, New Approach Methodologies are favoured. The S4 + OMC‐NC improved cell survival under SSL and showed antimutagenic properties, making it a promising candidate for safe photoprotection ...
Daniel Mabundu Kibwila, Alice Simon, Letícia Coli Louvisse de Abreu, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Marcelo de Pádula, Lucio Mendes Cabral   +6 more
wiley   +1 more source

DISSOLUTION MEDIA USED IN DEVELOPMENT AND QUALITY CONTROL OF DRUGS

Разработка и регистрация лекарственных средств, 2019
The main dissolution media recommended for the Dissolution test in Russia and abroad are represented in the review. Possible applications of biorelevant media and media with surfactants are also shown.
O. V. Druzhininskaya, I. E. Smekhova
doaj  

Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms

Brazilian Journal of Pharmaceutical Sciences, 2015
USP Apparatus 3 (reciprocating cylinder) is a very versatile device for the in vitro assessment of release characteristics of solid oral dosage forms, because it enables the product to be subjected to different dissolution media and agitation speeds in a
Bianca Ramos Pezzini, Michele Georges Issa, Marcelo Dutra Duque, Humberto Gomes Ferraz   +3 more
doaj   +1 more source

Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans [PDF]

, 2017
The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT).
Caroline L. Hoad, Deanna M. Mudie, EMA, EMA, FDA, FDA, Gordon L. Amidon, Gregory E. Amidon, Jeff Wright, Kathryn Murray, Khaled Heissam, Luca Marciani, Marciani L., Martin C. Garnett, Nichola Abrehart, Penny A. Gowland, Robin C. Spiller, Salem Al Atwah, Susan E. Pritchard   +18 more
core   +1 more source

Photo‐Autocatalysis: Insights From Light‐Driven Self‐Catalyzed Organic Transformations

Chemistry – An Asian Journal, Volume 21, Issue 2, 28 January 2026.
This perspective highlights recent advancements in photo‐autocatalytic reactions—light‐driven processes characterized by self‐accelerating kinetics. We explore the underlying mechanisms, demonstrating how photo‐autocatalysis can be realized either through a single photo‐autocatalyst or through a combination of a photocatalyst and an autocatalyst, and ...
James Shao‐Jiun Yang, Aira Shayne Paculba, Hsuan‐Hung Liao   +2 more
wiley   +1 more source

Characterization of biosurfactants’ micelles formation using fluorescence measurements: sodium taurocholate as case of study

ADMET and DMPK
Background and purpose: The evaluation of micellization parameters of surfactants that aggregate gradually, such as bile salts, is not trivial. In this work, different probes and data treatment models are tested to set up an analytical method based on ...
Susana Amézqueta, Elisabet Fuguet, Rubén Cabañas, Clara Ràfols   +3 more
doaj   +1 more source