Results 91 to 100 of about 17,248,582 (189)

Performing a physiologically relevant test for cladribine tablets

Разработка и регистрация лекарственных средств
Introduction. The introduction of devices – analogues of GIS (hereinafter–- Gastro-intestinal simulator) is one of the current ways to develop in-vitro assessment of the quality of solid dosage forms.
P. A. Losenkova, D. D. Gvozdev, A. V. Suvorova, Yu. V. Medvedev, V. S. Shcherbakova, Yu. G. Kazaishvili, K. Ya. Zaslavskaya, A. M. Poluyanov, I. E. Shohin   +8 more
doaj   +1 more source

Monitoring media pluralism in Europe : application of the media pluralism monitor 2016 in the European Union, Montenegro and Turkey [PDF]

, 2017
This report presents the results and the methodology of the 2016 implementation of the Media Pluralism Monitor (MPM) in EU-28 countries and in Montenegro and Turkey (MPM2016), carried out by the Centre for Media Pluralism and Media Freedom, EUI.
Centre for Media Pluralism and Media Freedom
core   +1 more source

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Pharmaceutics, 2019
The formulation of arylpropionic acid derivatives (profens), which are poorly soluble Biopharmaceutical Classification System (BCS) Type II drugs, has a strong impact on their therapeutic action.
Athanasios Mantas, Valentine Labbe, Irena Loryan, Albert Mihranyan   +3 more
doaj   +1 more source

A COMPARATIVE STUDY OF DRUG RELEASE FROM POLYCOMPLEX MATRICES IN STANDARD AND BIORELEVANT MEDIA USING USP III AND USP IV APPARATUS

Разработка и регистрация лекарственных средств, 2019
The results of Indomethacin release from the oral drug delivery systems based on interpolymer complexes with Eudragit® copolymers are presented.
A. V. Sitenkova (Bukhovets), N. Fotaki, R. I. Moustafine   +2 more
doaj  

The development and validation of analytical methods for the quantitative determination of dabigatran etexilate by HPLC-DAD and UV spectrophotometry during a comparative dissolution kinetics test of dabigatran capsules in the biorelevant FaSSGF medium

Разработка и регистрация лекарственных средств
Introduction. Venous thromboembolism and atrial fibrillation are significant causes of vascular mortality. Anticoagulant therapy significantly reduces the risk of ischemic stroke, and dabigatran etexilate, a direct thrombin inhibitor, has become firmly ...
D. M. Devyatkina, P. S. Mashchenko, A. D. Vnutskikh, I. O. Devyatkin, N. A. Prozorova, A. V. Foteeva   +5 more
doaj   +1 more source

Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution

Acta Pharmaceutica, 2014
Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in ...
Stojković Aleksandra, Tajber Lidia, Paluch Krzysztof J., Djurić Zorica, Parojčić Jelena, Corrigan Owen I.   +5 more
doaj   +1 more source

Biorelevant characterization of biopolymers

, 2003
Polymeric biomaterials are synthetically derived or modified biological polymers designed for in vivo use or for use in the proximity of biological fluids.
Ophir, Zohar, Pai, Vaishali, Jaffe, Michael   +2 more
core   +1 more source

Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range

ADMET and DMPK, 2016
Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility.
Joerg Berghausen, Frank Hans Seiler, Nathalie Gobeau, Bernard Faller   +3 more
doaj   +1 more source

Prediction of In Vitro Drug Dissolution into Fed-state Biorelevant Media: Contributions of Solubility Enhancement and Relatively Low Colloid Diffusivity. [PDF]

Eur J Pharm Sci, 2022
Jamil R, Polli JE.
europepmc   +1 more source

Solubility of Piperine and Its Inclusion Complexes in Biorelevant Media and Their Effect on Attenuating Mouse Ileum Contractions. [PDF]

ACS Omega, 2021
Ezawa T, Inagaki Y, Kashiwaba K, Matsumoto N, Moteki H, Murata I, Inoue Y, Kimura M, Ogihara M, Kanamoto I.   +9 more
europepmc   +1 more source