Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir [PDF]
, 2019 The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir
Bhagat, Snehal B. +6 more
core +1 more source
Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies [PDF]
, 2019 Background Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety.
Benedé, Sara +14 more
core +1 more source
Concentration and composition dependent aggregation of Pluronic- and Poly-(2-oxazolin)-Efavirenz Formulations in Biorelevant Media [PDF]
, 2021 Sebastian Endres +9 more
openalex +2 more sources
THE FEATURES OF THE PREDICTIVE DISSOLUTION TESTING (REVIEW)
Разработка и регистрация лекарственных средств, 2019 Dissolution test plays an important role at different levels of the development and manufacturing drugs as one of the major quality control tools and an integral part of In vitro tests in the study of drug release from the developed dosage forms. Article
R. I. Moustafine +2 more
doaj
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates +26 more
wiley +1 more source
Evaluation of a Three Compartment In Vitro Gastrointestinal Simulator Dissolution Apparatus to Predict In Vivo Dissolution [PDF]
, 2014 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109359/1/jps24112 ...
Amidon, Gordon L. +3 more
core +1 more source
In vitro conditions for performance evaluation of products for intravascular administration:Developing appropriate test media using Amphotericin B as a model drug [PDF]
, 2020 Currently, there are no compendial in vitro release tests specifically indicated for parenteral formulations. Consideration of biorelevant and clinically relevant test media represents a valuable approach for the development of in vitro tests that ...
D'Arcy, Deirdre M +2 more
core +1 more source
Toward Integrative Predictive Toxicology: Advanced Methods for Drug Toxicity and Safety Prediction
WIREs Computational Molecular Science, Volume 16, Issue 1, January/February 2026.This figure summarizes the different methods in integrative predictive toxicology reviewed in this work, ranging from exploration of molecular mechanisms to in silico pharmacokinetic modeling and construction of adverse outcome pathway (AOP) networks based on key events (KEs) and key event relationships (KERs). Further integration with multi‐omics data
Eleonora Gianquinto +6 more
wiley +1 more source
Терапевтический архив, 2020 Introduction.Tuberculosis (TB) is one of the top ten causes of death worldwide. Improvement of the treatment options via development of new drugs and treatment regimens that would be more convenient for patients is one of key options of improving the ...
A. L. Khokhlov +7 more
doaj +1 more source
Evolution of a physiological pH 6.8 bicarbonate buffer system: application to the dissolution testing of enteric coated products. [PDF]
, 2011 The use of compendial pH 6.8 phosphate buffer to assess dissolution of enteric coated products gives rise to poor in vitro-in vivo correlations because of the inadequacy of the buffer to resemble small intestinal fluids.
Abdul W. Basit +44 more
core +1 more source