Results 121 to 130 of about 1,404 (160)

Biorelevant dissolution media as a predictive tool for glyburide a class II drug

European Journal of Pharmaceutical Sciences, 2006
The purpose of this study was to predict the oral absorption of glyburide. Biorelevant dissolution methods, combined with permeability measurements and computational simulations, were used to predict the oral absorption of glyburide. The objective was to establish in vitro/in vivo correlations (IVIVCs) based on the biopharmaceutics drug classification ...
Raimar Löbenberg
exaly   +4 more sources

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Understanding the interaction between Soluplus® and biorelevant media components

Colloids and Surfaces B: Biointerfaces, 2020
Soluplus® (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) is a solubilizing copolymer commonly applied as carrier in solid dispersions of poorly soluble drugs. This polymer is used to increase the apparent solubility of drugs with low aqueous solubility and consequently enhance drug absorption by the human gastrointestinal
Juliana Munari Oliveira Pinto, Andrés Felipe Chamorro Rengifo, Cassiana Mendes, Aline Franciane Leão, Alexandre Luis Parize, Hellen Karine Stulzer   +5 more
openaire   +2 more sources

An investigation of the disintegration of tablets in biorelevant media

International Journal of Pharmaceutics, 2005
The purpose of the study was to examine the disintegration of tablets in media designed to simulate conditions pertaining in the stomach. Although many studies have been performed to determine dissolution rates in these media, little work has been undertaken on the preliminary step in dissolution, namely disintegration.
Anwar, S., Fell, J. T., Dickinson, P. A.
openaire   +3 more sources

Dissolution of solid lipid extrudates in biorelevant media

International Journal of Pharmaceutics, 2012
Solid lipid extrudates with the model drug praziquantel were produced with chemically diverse lipids and investigated regarding their dissolution behaviour in different media. The lipids used in this study were glyceryl tripalmitate, glyceryl dibehenate, glyceryl monostearate, cetyl palmitate and solid paraffin.
R, Witzleb, A, Müllertz, V-R, Kanikanti, H-J, Hamann, P, Kleinebudde   +4 more
openaire   +2 more sources

Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study

Molecular Pharmaceutics, 2017
Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with these methods.
Mann, James; Dressman, Jennifer; Rosenblatt, Karin; Ashworth, Lee; Muenster, Uwe; Frank, Kerstin; Hutchins, Paul; Williams, James; Klumpp, Lukas; Wielockx, Kristina; Berben, Philippe; Augustijns, Patrick; Holm, Rene; Hofmann, Michael; Patel, Sanjaykumar; Beato, Stefania; Ojala, Krista; Tomaszewska, Irena; Bruel, Jean-Luc; Butler, James   +20 more
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Biorelevant dissolution media: Aggregation of amphiphiles and solubility of estradiol

Journal of Pharmaceutical Sciences, 2006
Biorelevant dissolution media containing bile salt and lecithin at concentrations appropriate for fed and fasted state are useful when testing oral solid formulations of poorly water-soluble drugs. Dilution of amphiphile solutions affects the aggregation state of the amphiphiles because bile salt is partitioned between the aqueous phase and the ...
Ilardia-Arana, David, Kristensen, Henning G, Müllertz, Anette   +2 more
openaire   +3 more sources

Enhanced stability of polyacrylate-coated magnetite nanoparticles in biorelevant media

Colloids and Surfaces B: Biointerfaces, 2012
Magnetite nanoparticles (MNPs) were prepared by alkaline hydrolysis of Fe(II) and Fe(III) chlorides. Adsorption of polyacrylic acid (PAA) on MNPs was measured at pH=6.5±0.3 and I=0.01 M (NaCl) to find the optimal PAA amount for MNP stabilization under physiological conditions.
Angéla, Hajdú, Márta, Szekeres, Ildikó Y, Tóth, Rita A, Bauer, Judith, Mihály, István, Zupkó, Etelka, Tombácz   +6 more
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Investigation of monensin Type A medicated article dissolution profiles in biorelevant media

Journal of Veterinary Pharmacology and Therapeutics, 2020
AbstractIn the United States, a generic Type A medicated article (premix) product can gain government approval by demonstrating in vivo bioequivalence (BE) to the pioneer product in a blood level, pharmacodynamic, or clinical BE study. A biowaiver can be granted based on several criteria including solubility or a dose adjusted method.
Beverly J. Krabel, Laura B. Foust, Gary B. Fuller, Andrew J. Foss, Luke H. Garner, Robert P. Hunter   +5 more
openaire   +2 more sources

XAS Investigation of biorelevant cobalt complexes in aqueous media

New Journal of Chemistry, 2006
Cobalt is an essential element of biological cycles involved in numerous metallobiomolecules, but it becomes a toxic element at high concentration or a radiotoxic element because of its use in the nuclear industry. “Molecular speciation” in biological media is an essential prerequisite to evaluate its chemical behaviour as well as its toxic or ...
Bresson, C., Esnouf, S., Lamouroux, C., Solari, P.-L., den Auwer, C.   +4 more
openaire   +2 more sources

Importance of Critical Micellar Concentration for the Prediction of Solubility Enhancement in Biorelevant Media

Molecular Pharmaceutics, 2015
This study evaluated if the intrinsic surface properties of compounds are related to the solubility enhancement (SE) typically observed in biorelevant media like fasted state simulated intestinal fluids (FaSSIF). The solubility of 51 chemically diverse compounds was measured in FaSSIF and in phosphate buffer and the surface activity parameters were ...
G, Ottaviani, S, Wendelspiess, R, Alvarez-Sánchez   +2 more
exaly   +3 more sources