Results 141 to 150 of about 17,248,582 (189)

Solution Ensembles of Griselimycin Expand the Definition of Molecular Chameleonicity. [PDF]

J Med Chem
Hagemeyer LJ, Darling WTP, Hempel-Højgaard NJ, Kihlberg J, Erdelyi M.   +4 more
europepmc   +1 more source

Key Factors for Improving Predictive Accuracy and Avoiding Overparameterization of the PBPK Absorption Model in Food Effect Studies of Weakly Basic Water-Insoluble Compounds in Immediate Release Formulations. [PDF]

Pharmaceutics
Zhang M, Zhang S, Wang L, Zhang Z, Hu Q, Liu D.   +5 more
europepmc   +1 more source

Development of Practical Low-Volume Screening Method and Pharmacokinetic Simulation of Levofloxacin-Loaded Nanofiber Inserts for Sustained Ocular Therapy. [PDF]

Pharmaceutics
Abboud HA, Zelkó R, Kazsoki A.
europepmc   +1 more source

Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and its Regulatory Utility to Support Oral Drug Product Development and Harmonization. [PDF]

Pharm Res
Cheng YH, Thomas S, Tsang YC, Almeida S, Ashraf M, Fotaki N, Heimbach T, Patel N, Shah H, Jiang X, Kim MJ, Moody R, Rostami-Hodjegan A, Singh R, Zhao L, Babiskin A, Wu F.   +16 more
europepmc   +1 more source

A Reproducible Workflow for Macrophage Membrane Isolation and Nanocore Selection Toward Bioinspired Nanoparticles Targeting Immunologically Cold Tumors. [PDF]

Small Methods
Peixoto D, Diaz-Rodriguez P, Veiga F, Concheiro A, Paiva-Santos AC, Conde J, Alvarez-Lorenzo C.   +6 more
europepmc   +1 more source

Allicin-loaded soluplus polymeric micelles differentially modulate doxorubicin response in adenocarcinoma and myocardial cell models. [PDF]

Sci Rep
Al-Hadid KJ, Alshaer W, AlQuaissi B, Al-Momany BZ, Alsarayreh N, Alqudah DA, Alsheleh T.   +6 more
europepmc   +1 more source

Biorelevant Dissolution Media

, 2021
Biorelevant dissolution media are aqueous solutions or suspensions whose composition and physicochemical characteristics closely resemble human fluids found along the different portions of the gastrointestinal tract, developed to study the solubility and/or dissolution profile of orally administered drugs in a more physiologically relevant manner.
Ruiz, María Esperanza, Talevi, Alan
openaire   +3 more sources

Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media

European Journal of Pharmaceutics and Biopharmaceutics, 2011
The performance of the Ion-Selective Electrode (ISE) for in vitro dissolution testing using biorelevant media was evaluated in this study. In vitro dissolution was carried out using USP apparatus 2 (paddle method) with classical and with updated biorelevant media to simulate the pre- and postprandial states.
Jennifer Dressman
exaly   +5 more sources

Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study

Molecular Pharmaceutics, 2017
Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to gauge the reproducibility of results obtained with these methods.
Mann, James; Dressman, Jennifer; Rosenblatt, Karin; Ashworth, Lee; Muenster, Uwe; Frank, Kerstin; Hutchins, Paul; Williams, James; Klumpp, Lukas; Wielockx, Kristina; Berben, Philippe; Augustijns, Patrick; Holm, Rene; Hofmann, Michael; Patel, Sanjaykumar; Beato, Stefania; Ojala, Krista; Tomaszewska, Irena; Bruel, Jean-Luc; Butler, James   +20 more
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Importance of Critical Micellar Concentration for the Prediction of Solubility Enhancement in Biorelevant Media

Molecular Pharmaceutics, 2015
This study evaluated if the intrinsic surface properties of compounds are related to the solubility enhancement (SE) typically observed in biorelevant media like fasted state simulated intestinal fluids (FaSSIF). The solubility of 51 chemically diverse compounds was measured in FaSSIF and in phosphate buffer and the surface activity parameters were ...
G, Ottaviani, S, Wendelspiess, R, Alvarez-Sánchez   +2 more
exaly   +3 more sources