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Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging
Pharmaceutical Development and Technology, 2012The potential of UV imaging as a new small scale flow-through dissolution testing platform and its ability to incorporate biorelevant media was tested. Furosemide was utilized as a model poorly soluble drug, and dissolution media simulating conditions in the small intestine (5/1.25 mM and 40/10 mM bile salt/phospholipid, pH 6.5) together with ...
Gordon, Sarah +5 more
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Evaluation of biorelevant dissolution media simulating fasted and fed states
2018The most important criteria for evaluating in vitro performance and in vivo behavior of drugs is dissolution tests. It is necessary to provide conditions that best mimic the in vivo media in dissolution tests. The most important condition is the dissolution media used.
Yaşin, Diren Sarısaltık +1 more
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Influence of maltodextrin on meloxicam solubility in water and biorelevant media
Poorly soluble drugs are characterized by their limited solubility in aqueous media which affects their bioavailability, absorption efficiency, and ultimately their therapeutic potential. More than 70 % of molecules that are candidates for new drugs exhibit low water solubility, while 40 % of orally administered drugs with immediate release are ...Galić, Nives +2 more
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Update on Gastrointestinal Biorelevant Media and Physiologically Relevant Dissolution Conditions
Dissolution Technologies, 2022Daniela Amaral Silva +4 more
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