Results 161 to 170 of about 17,248,582 (189)
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Enhanced stability of polyacrylate-coated magnetite nanoparticles in biorelevant media
Colloids and Surfaces B: Biointerfaces, 2012Magnetite nanoparticles (MNPs) were prepared by alkaline hydrolysis of Fe(II) and Fe(III) chlorides. Adsorption of polyacrylic acid (PAA) on MNPs was measured at pH=6.5±0.3 and I=0.01 M (NaCl) to find the optimal PAA amount for MNP stabilization under physiological conditions.
Angéla, Hajdú +6 more
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Investigation of monensin Type A medicated article dissolution profiles in biorelevant media
Journal of Veterinary Pharmacology and Therapeutics, 2020AbstractIn the United States, a generic Type A medicated article (premix) product can gain government approval by demonstrating in vivo bioequivalence (BE) to the pioneer product in a blood level, pharmacodynamic, or clinical BE study. A biowaiver can be granted based on several criteria including solubility or a dose adjusted method.
Beverly J. Krabel +5 more
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XAS Investigation of biorelevant cobalt complexes in aqueous media
New Journal of Chemistry, 2006Cobalt is an essential element of biological cycles involved in numerous metallobiomolecules, but it becomes a toxic element at high concentration or a radiotoxic element because of its use in the nuclear industry. “Molecular speciation” in biological media is an essential prerequisite to evaluate its chemical behaviour as well as its toxic or ...
Bresson, C. +4 more
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Theoretical Dissolution Model of Poly-Disperse Drug Particles in Biorelevant Media
Journal of Pharmaceutical Sciences, 2008The purpose of the present study was to construct the theoretical dissolution model of poly-disperse drug particles in biorelevant media containing bile salt/ lecithin aggregates (micelles or vesicles). The effective diffusion coefficient in the biorelevant medium and the particle size distribution of drug particles were simultaneously factored into ...
Arimichi, Okazaki +2 more
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Journal of Pharmaceutical and Biomedical Analysis, 2018
The purpose of the present study was to investigate the precipitation of a drug on the particle surface of its salt in biorelevant media. Pioglitazone (PIO, weak base, pKa = 5.8) was used as a model drug. The crystal particles of PIO hydrochloride (PIO HCl) were immobilized between two slide glasses.
Taiga Uekusa, Kiyohiko Sugano
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The purpose of the present study was to investigate the precipitation of a drug on the particle surface of its salt in biorelevant media. Pioglitazone (PIO, weak base, pKa = 5.8) was used as a model drug. The crystal particles of PIO hydrochloride (PIO HCl) were immobilized between two slide glasses.
Taiga Uekusa, Kiyohiko Sugano
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Photocatalytic Arylations with Diazonium Salts in Aqueous and Biorelevant Media
ChemCatChemAbstract Performing designed, abiotic chemical transformations in live environments represents a powerful approach to interrogate and manipulate biology, and to uncover new types of biomedical tools. Despite significant advances in the area, the list of bio‐orthogonal reactions so far available is still very short, and mainly ...
Xulián Fernández‐González +3 more
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Biorelevant media resistant co-culture model mimicking permeability of human intestine
International Journal of Pharmaceutics, 2015Cell culture models are currently used to predict absorption pattern of new compounds and formulations in the human gastro-intestinal tract (GIT). One major drawback is the lack of relevant apical incubation fluids allowing mimicking luminal conditions in the GIT.
Delphine, Antoine +9 more
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Journal of Pharmaceutical and Biomedical Analysis, 2003
A new precise, rapid and selective high-performance-liquid-chromatographic (HPLC) method has been developed to quantify biapigenin in St. John's Wort (SJW) preparations and to investigate its release characteristics in the dissolution test using both compendial and biorelevant media.
S, Schulte-Löbbert +4 more
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A new precise, rapid and selective high-performance-liquid-chromatographic (HPLC) method has been developed to quantify biapigenin in St. John's Wort (SJW) preparations and to investigate its release characteristics in the dissolution test using both compendial and biorelevant media.
S, Schulte-Löbbert +4 more
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Molecular Pharmaceutics, 2018
Biorelevant dissolution media (BDM) methods are commonly employed to investigate the oral absorption of poorly water-soluble drugs. Despite the significant progress in this area, the effect of commonly employed pharmaceutical excipients, such as surfactants, on the solubility of drugs in BDM has not been characterized in detail.
Zahari Vinarov +4 more
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Biorelevant dissolution media (BDM) methods are commonly employed to investigate the oral absorption of poorly water-soluble drugs. Despite the significant progress in this area, the effect of commonly employed pharmaceutical excipients, such as surfactants, on the solubility of drugs in BDM has not been characterized in detail.
Zahari Vinarov +4 more
openaire +2 more sources