Results 151 to 160 of about 17,248,582 (189)
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Solubilization thermodynamics of ibuprofen in modified and classical FeSSIF biorelevant media
Journal of Molecular Liquids, 2013Abstract Some thermodynamic information related to the transfer of ibuprofen (IBP) between aqueous systems at pH 5.0 and micellar systems, in some biorelevant media, is reported. For this purpose, the apparent solubility of IBP at different temperatures, in the modified and classical Fed State Simulated Intestinal Fluid (FeSSIF) media, at different ...
Fleming Martínez
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Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media
Molecular Pharmaceutics, 2010A series of poorly soluble BCS class II compounds with "grease ball" characteristics were assessed for solubility and dissolution rate in biorelevant dissolution media (BDM) with the purpose of investigating which molecular structures gain most in solubility when dissolved under physiologically relevant conditions.
Alex Avdeef +2 more
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Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging
Pharmaceutical Development and Technology, 2012 The potential of UV imaging as a new small scale flow-through dissolution testing platform and its ability to incorporate biorelevant media was tested. Furosemide was utilized as a model poorly soluble drug, and dissolution media simulating conditions in the small intestine (5/1.25 mM and 40/10 mM bile salt/phospholipid, pH 6.5) together with ...
Gordon, Sarah +5 more
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Sources of dissolution variability into biorelevant media
International Journal of Pharmaceutics, 2022Identifying sources of dissolution variation is often challenging. Biorelevant dissolution media are compositionally complex, can require multiple steps to fabricate, and are utilized across differing laboratories. The objective was to determine the contributions of location, operator, media fabrication method, day, and tablet to total dissolution ...
Raqeeb, Jamil, James E, Polli
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European Journal of Pharmaceutics and Biopharmaceutics, 2017 Purpose To propose media for simulating the intragastric environment under reduced gastric acid secretion in the fasted state at three levels of simulation of the gastric environment and evaluate their usefulness in evaluating the intragastric ...
Christos Reppas +2 more
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An investigation of the disintegration of tablets in biorelevant media
International Journal of Pharmaceutics, 2005The purpose of the study was to examine the disintegration of tablets in media designed to simulate conditions pertaining in the stomach. Although many studies have been performed to determine dissolution rates in these media, little work has been undertaken on the preliminary step in dissolution, namely disintegration.
Anwar, S., Fell, J. T., Dickinson, P. A.
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Understanding the interaction between Soluplus® and biorelevant media components
Colloids and Surfaces B: Biointerfaces, 2020Soluplus® (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) is a solubilizing copolymer commonly applied as carrier in solid dispersions of poorly soluble drugs. This polymer is used to increase the apparent solubility of drugs with low aqueous solubility and consequently enhance drug absorption by the human gastrointestinal
Juliana Munari Oliveira Pinto +5 more
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Dissolution of solid lipid extrudates in biorelevant media
International Journal of Pharmaceutics, 2012Solid lipid extrudates with the model drug praziquantel were produced with chemically diverse lipids and investigated regarding their dissolution behaviour in different media. The lipids used in this study were glyceryl tripalmitate, glyceryl dibehenate, glyceryl monostearate, cetyl palmitate and solid paraffin.
R, Witzleb +4 more
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Biorelevant dissolution media: Aggregation of amphiphiles and solubility of estradiol
Journal of Pharmaceutical Sciences, 2006Biorelevant dissolution media containing bile salt and lecithin at concentrations appropriate for fed and fasted state are useful when testing oral solid formulations of poorly water-soluble drugs. Dilution of amphiphile solutions affects the aggregation state of the amphiphiles because bile salt is partitioned between the aqueous phase and the ...
Ilardia-Arana, David +2 more
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AAPS PharmSciTech, 2018 Physiologically based absorption modeling has been attracting increased attention to study the interactions of weakly basic drug compounds with acid-reducing agents like proton-pump inhibitors and H2 blockers.
Christos Reppas +2 more
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