Results 131 to 140 of about 1,404 (160)
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Theoretical Dissolution Model of Poly-Disperse Drug Particles in Biorelevant Media
Journal of Pharmaceutical Sciences, 2008The purpose of the present study was to construct the theoretical dissolution model of poly-disperse drug particles in biorelevant media containing bile salt/ lecithin aggregates (micelles or vesicles). The effective diffusion coefficient in the biorelevant medium and the particle size distribution of drug particles were simultaneously factored into ...
Arimichi, Okazaki +2 more
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Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media
Molecular Pharmaceutics, 2010A series of poorly soluble BCS class II compounds with "grease ball" characteristics were assessed for solubility and dissolution rate in biorelevant dissolution media (BDM) with the purpose of investigating which molecular structures gain most in solubility when dissolved under physiologically relevant conditions.
Jonas H Fagerberg +2 more
exaly +3 more sources
Journal of Pharmaceutical and Biomedical Analysis, 2018
The purpose of the present study was to investigate the precipitation of a drug on the particle surface of its salt in biorelevant media. Pioglitazone (PIO, weak base, pKa = 5.8) was used as a model drug. The crystal particles of PIO hydrochloride (PIO HCl) were immobilized between two slide glasses.
Taiga Uekusa, Kiyohiko Sugano
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The purpose of the present study was to investigate the precipitation of a drug on the particle surface of its salt in biorelevant media. Pioglitazone (PIO, weak base, pKa = 5.8) was used as a model drug. The crystal particles of PIO hydrochloride (PIO HCl) were immobilized between two slide glasses.
Taiga Uekusa, Kiyohiko Sugano
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Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media
European Journal of Pharmaceutics and Biopharmaceutics, 2011The performance of the Ion-Selective Electrode (ISE) for in vitro dissolution testing using biorelevant media was evaluated in this study. In vitro dissolution was carried out using USP apparatus 2 (paddle method) with classical and with updated biorelevant media to simulate the pre- and postprandial states.
Jennifer B Dressman
exaly +4 more sources
Solubilization thermodynamics of ibuprofen in modified and classical FeSSIF biorelevant media
Journal of Molecular Liquids, 2013Abstract Some thermodynamic information related to the transfer of ibuprofen (IBP) between aqueous systems at pH 5.0 and micellar systems, in some biorelevant media, is reported. For this purpose, the apparent solubility of IBP at different temperatures, in the modified and classical Fed State Simulated Intestinal Fluid (FeSSIF) media, at different ...
Fleming Martinez
exaly +2 more sources
Biorelevant media resistant co-culture model mimicking permeability of human intestine
International Journal of Pharmaceutics, 2015Cell culture models are currently used to predict absorption pattern of new compounds and formulations in the human gastro-intestinal tract (GIT). One major drawback is the lack of relevant apical incubation fluids allowing mimicking luminal conditions in the GIT.
Delphine, Antoine +9 more
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Photocatalytic Arylations with Diazonium Salts in Aqueous and Biorelevant Media
ChemCatChemAbstract Performing designed, abiotic chemical transformations in live environments represents a powerful approach to interrogate and manipulate biology, and to uncover new types of biomedical tools. Despite significant advances in the area, the list of bio‐orthogonal reactions so far available is still very short, and mainly ...
Xulián Fernández‐González +3 more
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2022
Bioavailability is one of the most important indicators in assessing the absorption of vitamins by a living organism. Bioavailability is the assessment of the amount of nutrients absorbed from food/feed products through the gastrointestinal tract of an organism.
Li, N.G. +5 more
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Bioavailability is one of the most important indicators in assessing the absorption of vitamins by a living organism. Bioavailability is the assessment of the amount of nutrients absorbed from food/feed products through the gastrointestinal tract of an organism.
Li, N.G. +5 more
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Molecular Pharmaceutics, 2018
Biorelevant dissolution media (BDM) methods are commonly employed to investigate the oral absorption of poorly water-soluble drugs. Despite the significant progress in this area, the effect of commonly employed pharmaceutical excipients, such as surfactants, on the solubility of drugs in BDM has not been characterized in detail.
Zahari Vinarov +4 more
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Biorelevant dissolution media (BDM) methods are commonly employed to investigate the oral absorption of poorly water-soluble drugs. Despite the significant progress in this area, the effect of commonly employed pharmaceutical excipients, such as surfactants, on the solubility of drugs in BDM has not been characterized in detail.
Zahari Vinarov +4 more
openaire +2 more sources
Journal of Pharmaceutical and Biomedical Analysis, 2003
A new precise, rapid and selective high-performance-liquid-chromatographic (HPLC) method has been developed to quantify biapigenin in St. John's Wort (SJW) preparations and to investigate its release characteristics in the dissolution test using both compendial and biorelevant media.
S, Schulte-Löbbert +4 more
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A new precise, rapid and selective high-performance-liquid-chromatographic (HPLC) method has been developed to quantify biapigenin in St. John's Wort (SJW) preparations and to investigate its release characteristics in the dissolution test using both compendial and biorelevant media.
S, Schulte-Löbbert +4 more
openaire +2 more sources