Results 111 to 120 of about 1,404 (160)

Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability. [PDF]

Pharmaceutics
Koch N, Bourcy Q, Jennotte O, Chiap P, Lechanteur A, Cardot JM, Evrard B.   +6 more
europepmc   +1 more source

Oral delivery of stabilized lipid nanoparticles for nucleic acid therapeutics. [PDF]

Drug Deliv Transl Res
Suri K, Pfeifer L, Cvet D, Li A, McCoy M, Singh A, Amiji MM.   +6 more
europepmc   +1 more source

Mucin Mimics and Impacts the Function of Polymeric Inhibitors in Stabilizing Drug Supersaturation. [PDF]

Mol Pharm
Kordorwu V, Castleberry S, Lustig S, Carrier RL.   +3 more
europepmc   +1 more source

Quality by Design-Based Formulation Development of an Oral Semaglutide Tablet. [PDF]

Pharmaceutics
Yoon JH, Kim DH, Kim JE.
europepmc   +1 more source

Exploring the impact of various zwitterionic surface modifications on the mucus diffusion and membrane permeability of lipid-based nanocarriers. [PDF]

Drug Deliv Transl Res
Spennacchio A, Richter LM, Stengel D, Hermann M, Lopedota AA, Lopalco A, Denora N, Bernkop-Schnürch A.   +7 more
europepmc   +1 more source

Bioavailability Enhancement and Polymorphic Stabilization of One BCS Class IV Metastable Drug Through Novel Formulation Approach. [PDF]

Turk J Pharm Sci
Panda R, Lankalapalli S.
europepmc   +1 more source

The Advancement of In Vitro Lipolysis: Two-Step Flow-Through Method for the Evaluation of Lipid-Based Drug Delivery Systems. [PDF]

Pharmaceutics
Rede K, Gašperlin M, Bogataj M, Bolko Seljak K.   +3 more
europepmc   +1 more source

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Sources of dissolution variability into biorelevant media

International Journal of Pharmaceutics, 2022
Identifying sources of dissolution variation is often challenging. Biorelevant dissolution media are compositionally complex, can require multiple steps to fabricate, and are utilized across differing laboratories. The objective was to determine the contributions of location, operator, media fabrication method, day, and tablet to total dissolution ...
Raqeeb, Jamil, James E, Polli
openaire   +2 more sources

The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug [PDF]

AAPS Journal, 2010
Simulation of gastrointestinal conditions is essential to adequately predict the in vivo behavior of drug formulations. To reduce the size and number of human studies required to identify a drug product with appropriate performance in both the fed and fasted states, it is advantageous to be able to pre-screen formulations in vitro.
Sandra Klein, Klein Sandra
exaly   +3 more sources

Biorelevant Dissolution Media

2021
Biorelevant dissolution media are aqueous solutions or suspensions whose composition and physicochemical characteristics closely resemble human fluids found along the different portions of the gastrointestinal tract, developed to study the solubility and/or dissolution profile of orally administered drugs in a more physiologically relevant manner.
Ruiz, María Esperanza, Talevi, Alan
openaire   +2 more sources