Results 111 to 120 of about 4,013 (240)
Pharmaceutics, 2019 The present study aimed to develop a novel formulation containing glutathione (GSH) as an oral antioxidant therapy for the treatment of oxidative stress-related intestinal diseases.
Serena Bertoni +4 more
doaj +1 more source
Mechanistic Studies of Drug Dissolution Testing : Implications of solid phase properties and in vivo prognostic media [PDF]
, 2010 Drug absorption after oral administration requires that the drug first dissolves into gastro-intestinal tract liquids. In vivo dissolution of a drug is affected by physiological and drug-related physicochemical factors.
Lehto, Paula
core
Performing a physiologically relevant test for cladribine tablets
Разработка и регистрация лекарственных средствIntroduction. The introduction of devices – analogues of GIS (hereinafter–- Gastro-intestinal simulator) is one of the current ways to develop in-vitro assessment of the quality of solid dosage forms.
P. A. Losenkova +8 more
doaj +1 more source
Antioxidant activity and cytotoxicity of solubilized C60 and its conjugates with butylated hydroxytoluene [PDF]
, 2011 It has been described that fullerenes (C60) present interesting properties with potential application in clinical conditions related to oxidative stress. One of the most prominent features of fullerenes is the ability to quench free radicals.
Caetano, Liliana Aranha +4 more
core
Predicting human intestinal absorption in the presence of bile salt with micellar liquid chromatography [PDF]
, 2016 Understanding intestinal absorption for pharmaceutical compounds is vital to estimate bioavailability and therefore the in vivo potential of a drug.
Parkes, Gareth M.B +2 more
core +1 more source
Frontiers in NutritionThis project aims to investigate the release performance of bilayer tablet (BL-Tablet) designed with both fast and slow-release technology, targeting sleep disorders.
Rebecca Bassetto +10 more
doaj +1 more source
Influence of cyclodextrins on loratadine solubility in water and in biorelevant media
Acta Marisiensis. Seria Medica, 2023 Introduction and objectives: Loratadine (LOR) is an antihistaminic drug, classified as BCS class II drug due to its low solubility and high permeability. Cyclodextrins (CD) are cyclic oligosaccharides known to improve solubility of poorly soluble drugs by forming inclusion complexes.
Pocrnić, Marijana, Galić, Nives
openaire
Pharmaceutics, 2019 The formulation of arylpropionic acid derivatives (profens), which are poorly soluble Biopharmaceutical Classification System (BCS) Type II drugs, has a strong impact on their therapeutic action.
Athanasios Mantas +3 more
doaj +1 more source
Acta Pharmaceutica, 2014 Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in ...
Stojković Aleksandra +5 more
doaj +1 more source