Results 81 to 90 of about 17,248,582 (189)

Charge Regulation in Crowded Solutions of a Weak Polyelectrolyte: Steric Interactions

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
Weak polyelectrolytes (WPE) solvated in biorelevant media and synthetic complex fluids that contain substantial concentrations of macromolecules, molecular assemblies, and nanoparticles are observed to exhibit deviations from the acid–base equilibrium observed in single‐component solutions.
David Attia, Evgenee Yekymov, Rachel Yerushalmi‐Rozen   +2 more
wiley   +1 more source

A Comprehensive Study of Solid Lipid Microparticles (SLMs) Behavior in Biorelevant Dissolution Media

, 2013
The aim of this research was to study the release performance of solid lipid microparticles (SLMs) in various biorelevant dissolution media simulating the conditions of the gastric tract and the proximal human intestine.
DI SABATINO, MARCELLO, PASSERINI, NADIA, ALBERTINI, BEATRICE   +2 more
core   +1 more source

Randomized, Placebo‐Controlled, First‐in‐Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Oral Doses of Novel Antitubercular Drug Candidate, GSK2556286, in Healthy Adults

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract This first‐in‐human study (ClinicalTrials.gov identifier: NCT04472897) evaluated the safety, tolerability, pharmacokinetics, and food effect of single ascending and repeat oral doses of GSK2556286 (GSK286), a novel antitubercular drug candidate with efficacy in animal models of tuberculosis.
Emma Ilsley, Edward Banham‐Hall, Tetyana Chaychenko, Katerina Chinenyeze, Gareth Maher‐Edwards, Catherine Muya, Katie Rolfe, Raman Sharma, Simon Tiberi, David Barros‐Aguirre   +9 more
wiley   +1 more source

Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media

, 2015
Co-amorphous formulations, particularly binary drug-amino acid mixtures, have been shown to provide enhanced dissolution for poorly-soluble drugs and improved physical stability of the amorphous state.
DeClerck, L., Grohganz, H., Laitinen, R., Heikkinen, A. T., Löbmann, Korbinian, Rades, T.   +5 more
core   +1 more source

Designing an effective dissolution test for bilayer tablets tailored for optimal melatonin release in sleep disorder management

Frontiers in Nutrition
This project aims to investigate the release performance of bilayer tablet (BL-Tablet) designed with both fast and slow-release technology, targeting sleep disorders.
Rebecca Bassetto, Emanuele Amadio, Francesco Ciampanelli, Stefano Perin, Pietro Ilari, Paolo Gaballo, Martina Callegari, Sara Feltrin, Jacopo Gobbo, Samuele Zanatta, Walter Bertin   +10 more
doaj   +1 more source

Glutathione-Loaded Solid Lipid Microparticles as Innovative Delivery System for Oral Antioxidant Therapy

Pharmaceutics, 2019
The present study aimed to develop a novel formulation containing glutathione (GSH) as an oral antioxidant therapy for the treatment of oxidative stress-related intestinal diseases.
Serena Bertoni, Beatrice Albertini, Carlotta Facchini, Cecilia Prata, Nadia Passerini   +4 more
doaj   +1 more source

Liveness Redux: On Media and Their Claim to be Live [PDF]

, 2017
Increasingly media are asserting themselves as live. In television, this has been an important strategy and recently it has been employed by new media platforms such as Facebook, Periscope and Snapchat.
van Es, K.F., ICON - Media and Performance Studies, LS Media en Communicatie, Karin van Es   +3 more
core   +1 more source

Impact of presence of excipients in drug analysis in fed-state gastric biorelevant media

European Journal of Pharmaceutics and Biopharmaceutics, 2018
In this study, the influence of the presence of excipients in sample preparation and clean-up steps required prior to drug analysis in milk-based media which simulate the in vivo properties of the fed state stomach was investigated. 15 excipients, normally present in solid dosage forms of five APIs tested (atenolol, paracetamol, furosemide, nifedipine ...
Baxevanis, Fotios, Kuiper, Jesse, Fotaki, Nikoletta   +2 more
openaire   +3 more sources

In silico bioavailability for BCS class II efavirenz tablets using biorelevant dissolution media for IVIVR and simulation of formulation changes

, 2021
This work aims to evaluate the ability of biorelevant dissolution media to simulate the bioavailability of efavirenz tablets, establish an in vitro–in vivo relationship (IVIVR) based on in vivo data using GastroPlus® and simulate formulation changes ...
Beatriz Ferreira de Carvalho Patricio (11593257), Helvécio Vinícius Antunes Rocha (4749126), Thalita Martins da Silva (11593245), Marcelo Henrique da Cunha Chaves (11593251), Lucio Mendes Cabral (11593254), Thiago da Silva Honorio (11593248), Marcelo Dutra Duque (5188076)   +6 more
core   +1 more source

Biorelevant in-vitro performance testing of orally administered dosage forms

, 2012
Objectives This review focuses on the evolution and current status of biorelevant media and hydrodynamics, and discusses the usefulness of biorelevant performance testing in the evaluation of specific dosage form related lumenal processes.
Vertzoni, M., Reppas, C.
core