Design of a Reconfigurable Microfluidic System Enabled by Magnetic Miniature Robots
Advanced Intelligent Systems, Volume 8, Issue 3, March 2026.Magnetic miniature robots are integrated into microfluidic chips to achieve real‐time reconfiguration. By external magnetic actuation, the robots perform sorting, mixing, flow regulation, and bubble removal on demand. This versatile platform eliminates the need for complex on‐chip hardware and enables adaptive control for biological and chemical ...
Yuanhe Chen +3 more
wiley +1 more source
Pharmaceutics, 2020 Biphasic dissolution systems achieved good predictability for the in vivo performance of several formulations of poorly water-soluble drugs by characterizing dissolution, precipitation, re-dissolution, and absorption.
Alexander Denninger +3 more
doaj +1 more source
Statistical investigation of simulated fed intestinal media composition on the equilibrium solubility of oral drugs [PDF]
, 2017 Gastrointestinal fluid is a complex milieu and it is recognised that gut drug solubility is different to that observed in simple aqueous buffers. Simulated gastrointestinal media have been developed covering fasted and fed states to facilitate in vitro ...
Dunn, Claire +4 more
core +1 more source
Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution [PDF]
, 2018 The measurement of physicochemical properties at an early phase of drug discovery and development is crucial to reduce attrition rates due to poor biopharmaceutical properties.
Bard, Bruno +5 more
core
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential [PDF]
, 2016 The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin.
Anand, Sridhar +5 more
core +2 more sources
Organic Electrochemical Transistors for Neuromorphic Devices and Applications
Advanced Materials, Volume 38, Issue 9, 12 February 2026.Organic electrochemical transistors are emerging as promising platforms for neuromorphic devices that emulate neuronal and synaptic activities and can seamlessly integrate with biological systems. This review focuses on resultant organic artificial neurons, synapses, and integrated devices, with an emphasis on their ability to perform neuromorphic ...
Kexin Xiang +4 more
wiley +1 more source
Dissolution Behavior of Flufenamic Acid in Heated Mixtures with Nanocellulose
Molecules, 2020 Flufenamic acid (FFA) is a problem drug that has up to eight different polymorphs and shows poor solubility. Variability in bioavailability has been reported in the past resulting in limited use of FFA in the oral solid dosage form.
Athanasios Mantas, Albert Mihranyan
doaj +1 more source
Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution [PDF]
, 2014 Traditional pharmaceutical dissolution tests determine the amount of drug dissolved over time by measuring drug content in the dissolution medium. This method provides little direct information about what is happening on the surface of the dissolving ...
Fussell, A.L. +4 more
core +3 more sources
Strategic drug analysis in fed-state gastric biorelevant media based on drug physicochemical properties [PDF]
European Journal of Pharmaceutics and Biopharmaceutics, 2018 Milk-based media such as the Fed State Simulated Gastric Fluid (FeSSGF) are commonly used in order to simulate the in vivo properties of the fed state stomach. Due to the lack of a specific guideline for standardised sample clean-up in these media, the aim of the current study was to develop an optimum protocol for the extraction and quantification of ...
Baxevanis, Fotios +2 more
openaire +2 more sources