Biorelevant dissolution of candesartan cilexetil [PDF]
ADMET and DMPK, 2017 The choice of an appropriate medium for dissolution tests is an essential step during a dosage form development. The adequate design of dissolution testing enables forecasting in vivo behavior of drug formulation.
Lucie Gruberová, Bohumil Kratochvil
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Mechanisms of drug solubilization by polar lipids in biorelevant media [PDF]
European Journal of Pharmaceutical Sciences, 2020 Despite the widespread use of lipid excipients in both academic research and oral formulation development, rational selection guidelines are still missing. In the current study, we aimed to establish a link between the molecular structure of commonly used polar lipids and drug solubilization in biorelevant media.
Vladimir Katev +2 more
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Impact of Permeation Enhancers on the Release of Insulin from Tablets in Biorelevant Media. [PDF]
Mol PharmThe use of chemical permeation enhancers (PEs) to improve the permeation of peptides across gastric and intestinal epithelia has proven an effective strategy in the development of oral dosage forms of peptides. However, there remains a poor understanding of how the presence of PEs impacts the dissolution characteristics of oral formulations containing ...
Fagan A +4 more
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Development and Characterization of a New Oral Antileishmanial Bis(pyridine-2-Carboxamidine) Drug Through Innovative Dissolution Testing in Biorelevant Media Combined with Pharmacokinetic Studies [PDF]
PharmaceuticsBackground/Objectives: Currently there are very few effective oral antileishmanial treatments. In this study we evaluated a new bis(pyridine-2-carboxamidine) antileishmanial drug (JNII40_base) and its hydrochloride salt (JNII40_HCl).
Almudena Laguna +6 more
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Formulation-dependent dissolution and bioaccessibility of curcuminoids and (S)-ar-turmerone from eight commercial turmeric extract- and curcumin-containing dietary supplements [PDF]
Pharmaceutical BiologyContext Curcumin-containing dietary supplements are widely marketed with claims of enhanced bioavailability, despite well-recognized limitations related to poor aqueous solubility, chemical instability, and extensive first-pass metabolism.
Bill J. Gurley +7 more
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Biorelevant dissolution media as a predictive tool for glyburide a class II drug
European Journal of Pharmaceutical Sciences, 2006 The purpose of this study was to predict the oral absorption of glyburide. Biorelevant dissolution methods, combined with permeability measurements and computational simulations, were used to predict the oral absorption of glyburide. The objective was to establish in vitro/in vivo correlations (IVIVCs) based on the biopharmaceutics drug classification ...
Raimar Löbenberg
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Development of biorelevant media and dissolution tests for gastrointestinal disease states
, 2022 Standard biorelevant media reflect the average gastrointestinal (GI) physiology in healthy volunteers. The use of biorelevant media in in vitro experiments has become an important strategy to predict drug behaviour in vivo and is often combined with in silico tools in order to simulate drug plasma profiles over time.
Šegregur, Domagoj
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SC Powder – domestic powder for the preparation of biorelevant media from the company Scientific Compliance [PDF]
Разработка и регистрация лекарственных средствThe use of biorelevant dissolution media makes it possible to reproduce conditions as in the human gastrointestinal tract. This expands the capabilities of laboratories involved in the analysis of solid dosage forms and allows obtaining physiologically ...
article Editorial
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The investigation of kinetics dissolution of prolonged indapamide drugs in biorelevant media
Сеченовский вестник, 2013 In the current work there was performed the development of the method of determination dissolution kinetics in biorelevant media of slightly soluble substance, for example indapamide. The method was validated in terms of specificity, linearity, precision,
E. Yu. Sannikova +3 more
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Stability of Biorelevant Media Under Various Storage Conditions
Dissolution Technologies, 2019 S.6-18The physical and chemical stability of various biorelevant media (FaSSGF, FaSSIF V1, FaSSIF V2, FaSSIF V3, and FeSSIF) were investigated over periods after preparation of up to 120 h at room temperature (RT) (22 degrees C) and 37 degrees C.
Lukas Klumpp +5 more
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