Results 11 to 20 of about 1,404 (160)

Modification of the Biorelevant Release Testing of Esophageal Applied Mucoadhesive Films and Development of Formulation Strategies to Increase the Mucosal Contact Time [PDF]

Pharmaceutics
The increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus.
Friederike Brokmann, Paul Simonek, Christoph Rosenbaum   +2 more
doaj   +2 more sources

The investigation of kinetics dissolution of prolonged indapamide drugs in biorelevant media

Сеченовский вестник, 2013
In the current work there was performed the development of the method of determination dissolution kinetics in biorelevant media of slightly soluble substance, for example indapamide. The method was validated in terms of specificity, linearity, precision,
E. Yu. Sannikova, A. A. Kruglyakova, I. E. Shokhin, G. V. Ramenskaya   +3 more
doaj   +1 more source

The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little [PDF]

International Journal of Pharmaceutics: X
Fluid co-administered with oral medication directly affects its behaviour. Often, people use fluids other than water when taking their medications. Capsules (mainly gelatine- and HPMC-based) are widely used solid oral dosage forms.
Dorota Sarwinska, Mathilde Leyh, Constantin Foja, Theodora Tzakri, Philipp Schick, Felix Morof, Julius Krause, James Mann, Richard Barker, Mladen Vassilev Tzvetkov, Werner Weitschies, Michael Grimm   +11 more
doaj   +2 more sources

Mechanistic Investigation into the Phase Separation Behavior of Soluplus in the Presence of Biorelevant Media. [PDF]

Mol Pharm
More than a decade since its introduction, the polymeric excipient Soluplus continues to receive considerable attention for its application in the development of amorphous solid dispersions (ASDs) and its utility as a solubilizer for drugs exhibiting solubility limited absorption.
Lange JJ, Senniksen MB, Wyttenbach N, Page S, Bateman LM, O'Dwyer PJ, Saal W, Kuentz M, Griffin BT.   +8 more
europepmc   +4 more sources

Impact of Permeation Enhancers on the Release of Insulin from Tablets in Biorelevant Media. [PDF]

Mol Pharm
The use of chemical permeation enhancers (PEs) to improve the permeation of peptides across gastric and intestinal epithelia has proven an effective strategy in the development of oral dosage forms of peptides. However, there remains a poor understanding of how the presence of PEs impacts the dissolution characteristics of oral formulations containing ...
Fagan A, Bateman LM, Crean AM, O'Shea JP, Taylor LS.   +4 more
europepmc   +3 more sources

Cocrystal Solubilization in Biorelevant Media and its Prediction from Drug Solubilization. [PDF]

J Pharm Sci, 2015
This work examines cocrystal solubility in biorelevant media (FeSSIF, fed-state simulated intestinal fluid), and develops a theoretical framework that allows for the simple and quantitative prediction of cocrystal solubilization from drug solubilization.
Lipert MP, Roy L, Childs SL, Rodríguez-Hornedo N.   +3 more
europepmc   +4 more sources

Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability

British Journal of Pharmacy, 2023
The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically ...
Erin Seonaid Campbell, Hannah Batchelor, James Matthew Butler, Ibrahim Khadra, Nena Minstry, Konstantinos Stamatopoulos   +5 more
doaj   +1 more source

Development and Validation of an HPLC-UV Method for the Dissolution Studies of 3D-Printed Paracetamol Formulations in Milk-Containing Simulated Gastrointestinal Media

Pharmaceuticals, 2022
Herein, a simple and rapid HPLC method for the determination of paracetamol milk-containing biorelevant media is proposed. The separation of the analyte from the milk-containing biorelevant media was accomplished isocratically using a mobile phase ...
Natalia Manousi, Christina Karavasili, Dimitrios G. Fatouros, Paraskevas D. Tzanavaras, Constantinos K. Zacharis   +4 more
doaj   +1 more source

Remote Activation of Hollow Nanoreactors for Heterogeneous Photocatalysis in Biorelevant Media [PDF]

Nano Letters, 2020
Major current challenges in nano-biotechnology and nano-biomedicine include the implementation of predesigned chemical reactions in biological environments. In this context, heterogeneous catalysis is emerging as a promising approach to extend the richness of organic chemistry onto the complex environments inherent to living systems.
Ana Sousa-Castillo, José R. Couceiro, María Tomás-Gamasa, Andrea Mariño-López, Fernando López, Walid Baaziz, Ovidiu Ersen, Miguel Comesaña-Hermo, José L. Mascareñas, Miguel A. Correa-Duarte   +9 more
openaire   +6 more sources

Understanding the Impact of Age-Related Changes in Pediatric GI Solubility by Multivariate Data Analysis

Pharmaceutics, 2022
The aim of this study was to understand drug solubilization as a function of age and identify drugs at risk of altered drug solubility in newborns and young infants in comparison to adults.
Mariana Guimarães, Anil Maharaj, Andrea Edginton, Maria Vertzoni, Nikoletta Fotaki   +4 more
doaj   +1 more source