Metabolic Stability of D-Allulose in Biorelevant Media and Hepatocytes: Comparison with Fructose and Erythritol [PDF]
Foods, 2019 D-allulose, a C-3 epimer of D-fructose, is a rare monosaccharide used as a food ingredient or a sweetener. In the present study, the in vitro metabolic stability of D-allulose was examined in biorelevant media, that is, simulated gastric fluid (SGF) and ...
Han-Joo Maeng +8 more
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Mechanisms of Drug Solubilization by Polar Lipids in Biorelevant Media
European Journal of Pharmaceutical Sciences, 2020 Despite the widespread use of lipid excipients in both academic research and oral formulation development, rational selection guidelines are still missing. In the current study, we aimed to establish a link between the molecular structure of commonly used polar lipids and drug solubilization in biorelevant media.
Vladimir Katev +2 more
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Technical Note: Using Biorelevant Media with Different Types of Orally Administered Formulations
Dissolution Technologies, 2010 One of the most important aims of formulation development for a poorly soluble new chemical entity (NCE) or active pharmaceutical ingredient (API) is to enhance bioavailability. For orally administered compounds, this can be broadly assessed by knowing the solubility and the permeability of a compound.
Bastian Kloefer, Peter van Hoogevest
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Characterization of Affitin proteolytic digestion in biorelevant media and improvement of their stabilities via protein engineering. [PDF]
Sci Rep, 2020 Loussouarn A +4 more
europepmc +3 more sources
Formulation-dependent dissolution and bioaccessibility of curcuminoids and (S)-ar-turmerone from eight commercial turmeric extract- and curcumin-containing dietary supplements [PDF]
Pharmaceutical BiologyContext Curcumin-containing dietary supplements are widely marketed with claims of enhanced bioavailability, despite well-recognized limitations related to poor aqueous solubility, chemical instability, and extensive first-pass metabolism.
Bill J. Gurley +7 more
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Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range [PDF]
ADMET and DMPK, 2016 Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility.
Joerg Berghausen +3 more
doaj +4 more sources
Modification of the Biorelevant Release Testing of Esophageal Applied Mucoadhesive Films and Development of Formulation Strategies to Increase the Mucosal Contact Time [PDF]
PharmaceuticsThe increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus.
Friederike Brokmann +2 more
doaj +2 more sources
Solubility of Piperine and Its Inclusion Complexes in Biorelevant Media and Their Effect on Attenuating Mouse Ileum Contractions. [PDF]
ACS Omega, 2021 Ezawa T +9 more
europepmc +3 more sources
Development of Fluorescent Sensors for Biorelevant Anions in Aqueous Media Using Positively Charged Quantum Dots [PDF]
MicromachinesQuantum dots (QDs) have captured the attention of the scientific community due to their unique optical and electronic properties, leading to extensive research for different applications. They have also been employed as sensors for ionic species owing to
Hitalo J. B. Silva +3 more
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Polyelectrolyte coating on superparamagnetic iron oxide nanoparticles as interface between magnetic core and biorelevant media. [PDF]
Interface Focus, 2016 Tombácz E +7 more
europepmc +3 more sources