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The biosynthesis of the cannabinoids [PDF]
Journal of Cannabis Research, 2021 Abstract Cannabis has been integral to Eurasian civilization for millennia, but a century of prohibition has limited investigation. With spreading legalization, science is pivoting to study the pharmacopeia of the cannabinoids, and a thorough understanding of their biosynthesis is required to engineer strains with ...
M. Nazir Tahir +3 more
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AMB Express, 2021 Reprogramming glycolysis for directing glycolytic metabolites to a specific metabolic pathway is expected to be useful for increasing microbial production of certain metabolites, such as amino acids, lipids or considerable secondary metabolites.
Hailong Chen +7 more
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Frontiers in Plant Science, 2022 Plants produce a wide variety of pharmacologically active molecules classified as natural products. Derivatization of these natural products can modulate or improve the bioactivity of the parent compound. Unfortunately, chemical derivatization of natural
Marianna Boccia +4 more
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Biocatalytic routes to stereo-divergent iridoids
Nature Communications, 2022 Iridoid compounds are an important class of natural products. Here, the authors report on the discovery and engineering of nepetalactol-related short chain reductases and their application for the biosynthesis of nepetalactol or nepetalactone ...
Néstor J. Hernández Lozada +12 more
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Cell Death and Disease, 2021 Increased reactive oxygen species levels in the mitochondrial matrix can induce Parkin-dependent mitophagy, which selectively degrades dysfunctional mitochondria via the autolysosome pathway. Phosphorylated mitofusin-2 (MFN2), a receptor of parkin RBR E3
Cheng Zhang +11 more
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SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System
mBio, 2021 We recently found that SspABCD, catalyzing single-stranded (ss) DNA phosphorothioate (PT) modification, coupled with SspE provides protection against phage infection.
Shiwei Wang +12 more
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Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments
Microbial Cell Factories, 2022 Epidemic diseases and antibiotic resistance are urgent threats to global health, and human is confronted with an unprecedented dilemma to conquer them by expediting development of new natural product related drugs.
Meng Zhang +7 more
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Frontiers in Microbiology, 2020 Microbial natural products have been a cornerstone of the pharmaceutical industry, but the supply of novel bioactive secondary metabolites has diminished due to extensive exploration of the most easily accessible sources, namely terrestrial Streptomyces ...
Soheila Matroodi +6 more
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Microbial Cell Factories, 2022 Background Saccharomyces cerevisiae is often used as a cell factory for the production of S-adenosyl-l-methionine (SAM) for diverse pharmaceutical applications. However, SAM production by S.
Hailong Chen +7 more
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The biosynthesis of pyoverdines [PDF]
Microbial Cell, 2018 Pyoverdines are fluorescent siderophores of pseudomonads that play important roles for growth under iron-limiting conditions. The production of pyoverdines by fluorescent pseudomonads permits their colonization of hosts ranging from humans to plants.
Michael T. Ringel, Thomas Brüser
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