Results 1 to 10 of about 681,288 (296)

Increasing glycolysis by deletion of kcs1 and arg82 improved S-adenosyl-l-methionine production in Saccharomyces cerevisiae

AMB Express, 2021
Reprogramming glycolysis for directing glycolytic metabolites to a specific metabolic pathway is expected to be useful for increasing microbial production of certain metabolites, such as amino acids, lipids or considerable secondary metabolites.
Hailong Chen, Nianqing Zhu, Yan Wang, Xinxin Gao, Yuhe Song, Jia Zheng, Jiaping Peng, Xin Zhang   +7 more
doaj   +1 more source

Biocatalytic routes to stereo-divergent iridoids

Nature Communications, 2022
Iridoid compounds are an important class of natural products. Here, the authors report on the discovery and engineering of nepetalactol-related short chain reductases and their application for the biosynthesis of nepetalactol or nepetalactone ...
Néstor J. Hernández Lozada, Benke Hong, Joshua C. Wood, Lorenzo Caputi, Jérôme Basquin, Ling Chuang, Maritta Kunert, Carlos E. Rodríguez López, Chloe Langley, Dongyan Zhao, C. Robin Buell, Benjamin R. Lichman, Sarah E. O’Connor   +12 more
doaj   +1 more source

Directed Biosynthesis of New to Nature Alkaloids in a Heterologous Nicotiana benthamiana Expression Host

Frontiers in Plant Science, 2022
Plants produce a wide variety of pharmacologically active molecules classified as natural products. Derivatization of these natural products can modulate or improve the bioactivity of the parent compound. Unfortunately, chemical derivatization of natural
Marianna Boccia, Dagny Grzech, Adriana A. Lopes, Sarah E. O’Connor, Lorenzo Caputi   +4 more
doaj   +1 more source

Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner

Cell Death and Disease, 2021
Increased reactive oxygen species levels in the mitochondrial matrix can induce Parkin-dependent mitophagy, which selectively degrades dysfunctional mitochondria via the autolysosome pathway. Phosphorylated mitofusin-2 (MFN2), a receptor of parkin RBR E3
Cheng Zhang, Pengqing Nie, Chunliu Zhou, Yue Hu, Suling Duan, Meijia Gu, Dongxu Jiang, Yunfu Wang, Zixin Deng, Jincao Chen, Shi Chen, Lianrong Wang   +11 more
doaj   +1 more source

SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System

mBio, 2021
We recently found that SspABCD, catalyzing single-stranded (ss) DNA phosphorothioate (PT) modification, coupled with SspE provides protection against phage infection.
Shiwei Wang, Mengping Wan, Ruolin Huang, Yujing Zhang, Yuqing Xie, Yue Wei, Mustafa Ahmad, Dan Wu, Yue Hong, Zixin Deng, Shi Chen, Zhiqiang Li, Lianrong Wang   +12 more
doaj   +1 more source

Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments

Microbial Cell Factories, 2022
Epidemic diseases and antibiotic resistance are urgent threats to global health, and human is confronted with an unprecedented dilemma to conquer them by expediting development of new natural product related drugs.
Meng Zhang, Liyuan Kong, Rong Gong, Marianna Iorio, Stefano Donadio, Zixin Deng, Margherita Sosio, Wenqing Chen   +7 more
doaj   +1 more source

Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic Streptomonospora sp. PA3

Frontiers in Microbiology, 2020
Microbial natural products have been a cornerstone of the pharmaceutical industry, but the supply of novel bioactive secondary metabolites has diminished due to extensive exploration of the most easily accessible sources, namely terrestrial Streptomyces ...
Soheila Matroodi, Soheila Matroodi, Vilja Siitonen, Bikash Baral, Keith Yamada, Amir Akhgari, Mikko Metsä-Ketelä   +6 more
doaj   +1 more source

The multiple effects of REG1 deletion and SNF1 overexpression improved the production of S-adenosyl-l-methionine in Saccharomyces cerevisiae

Microbial Cell Factories, 2022
Background Saccharomyces cerevisiae is often used as a cell factory for the production of S-adenosyl-l-methionine (SAM) for diverse pharmaceutical applications. However, SAM production by S.
Hailong Chen, Xiaoqin Chai, Yan Wang, Jing Liu, Guohai Zhou, Pinghe Wei, Yuhe Song, Lingman Ma   +7 more
doaj   +1 more source

Engineering Corynebacterium glutamicum for de novo production of 2-phenylethanol from lignocellulosic biomass hydrolysate

Biotechnology for Biofuels and Bioproducts, 2023
Background 2-Phenylethanol is a specific aromatic alcohol with a rose-like smell, which has been widely used in the cosmetic and food industries. At present, 2-phenylethanol is mainly produced by chemical synthesis.
Nianqing Zhu, Wenjing Xia, Guanglu Wang, Yuhe Song, Xinxing Gao, Jilei Liang, Yan Wang   +6 more
doaj   +1 more source

Effects of cadmium stress on seed germination and physiological-biochemical characteristics in okra: a comparative study of red and green varieties [PDF]

PeerJ
Previous study has demonstrated that okra (Abelmoschus esculentus (L.) Moench) is capable of accumulating cadmium (Cd) in both plants and fruits. However, there is still little known about the physiological responses of different okra cultivars to Cd ...
Wanwan Wang, Lei Yu, Xuexia Zhang, Jingbo Yu, Zhou Jiang, Long Xu, Haiyun Rui   +6 more
doaj   +2 more sources