Results 11 to 20 of about 1,587,544 (388)

SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System

open access: yesmBio, 2021
We recently found that SspABCD, catalyzing single-stranded (ss) DNA phosphorothioate (PT) modification, coupled with SspE provides protection against phage infection.
Shiwei Wang   +12 more
doaj   +1 more source

Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments

open access: yesMicrobial Cell Factories, 2022
Epidemic diseases and antibiotic resistance are urgent threats to global health, and human is confronted with an unprecedented dilemma to conquer them by expediting development of new natural product related drugs.
Meng Zhang   +7 more
doaj   +1 more source

Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic Streptomonospora sp. PA3

open access: yesFrontiers in Microbiology, 2020
Microbial natural products have been a cornerstone of the pharmaceutical industry, but the supply of novel bioactive secondary metabolites has diminished due to extensive exploration of the most easily accessible sources, namely terrestrial Streptomyces ...
Soheila Matroodi   +6 more
doaj   +1 more source

The multiple effects of REG1 deletion and SNF1 overexpression improved the production of S-adenosyl-l-methionine in Saccharomyces cerevisiae

open access: yesMicrobial Cell Factories, 2022
Background Saccharomyces cerevisiae is often used as a cell factory for the production of S-adenosyl-l-methionine (SAM) for diverse pharmaceutical applications. However, SAM production by S.
Hailong Chen   +7 more
doaj   +1 more source

Engineering Corynebacterium glutamicum for de novo production of 2-phenylethanol from lignocellulosic biomass hydrolysate

open access: yesBiotechnology for Biofuels and Bioproducts, 2023
Background 2-Phenylethanol is a specific aromatic alcohol with a rose-like smell, which has been widely used in the cosmetic and food industries. At present, 2-phenylethanol is mainly produced by chemical synthesis.
Nianqing Zhu   +6 more
doaj   +1 more source

Salicylic Acid Biosynthesis in Plants

open access: yesFrontiers in Plant Science, 2020
Salicylic acid (SA) is an important plant hormone that is best known for mediating host responses upon pathogen infection. Its role in plant defense activation is well established, but its biosynthesis in plants is not fully understood.
Hannes Lefevere, L. Bauters, G. Gheysen
semanticscholar   +1 more source

Polysaccharide Biosynthesis [PDF]

open access: yesThe Journal of General Physiology, 1966
Polysaccharide synthesis is discussed from the point of view of the sources of biological information that determine the structures and control the rates of synthesis of complex polysaccharides. It is concluded that three types of information contribute in important and different ways, namely enzyme specificity, primer substances, and the structure of ...
P W, Robbins, A, Wright, M, Dankert
openaire   +2 more sources

Oxytetracycline Biosynthesis [PDF]

open access: yesJournal of Biological Chemistry, 2010
Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. OTC is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive ...
Lauren B, Pickens, Yi, Tang
openaire   +2 more sources

Effects of cadmium stress on seed germination and physiological-biochemical characteristics in okra: a comparative study of red and green varieties [PDF]

open access: yesPeerJ
Previous study has demonstrated that okra (Abelmoschus esculentus (L.) Moench) is capable of accumulating cadmium (Cd) in both plants and fruits. However, there is still little known about the physiological responses of different okra cultivars to Cd ...
Wanwan Wang   +6 more
doaj   +2 more sources

Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]

open access: yes, 2009
OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali   +4 more
core   +2 more sources

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