Results 111 to 120 of about 379,309 (342)

Diversity and biosynthetic potential of culturable microbes associated with toxic marine animals [PDF]

, 2013
Tetrodotoxin (TTX) is a neurotoxin that has been reported from taxonomically diverse organisms across 14 different phyla. The biogenic origin of tetrodotoxin is still disputed, however, TTX biosynthesis by host-associated bacteria has been reported.
Chau, Rocky, Kalaitzis, John, Neilan, Brett, Wood, Susanna A.   +3 more
core   +4 more sources

The Transcriptional Architecture of Bacterial Biosynthetic Gene Clusters

Journal of Natural Products
AbstractBacteria produce diverse bioactive metabolites with ecological and pharmaceutical importance. These compounds are synthesized by biosynthetic gene clusters (BGCs), whose expression is tightly regulated. While many studies have examined the factors influencing BGC expression, including transcription factors (TFs) and environmental signals, the ...
Ribeiro Monteiro, Silvia, Kerdel, Yasmine, Gathot, Julianne, Rigali, Sébastien   +3 more
openaire   +2 more sources

Heterologous Expression of Novobiocin and Clorobiocin Biosynthetic Gene Clusters [PDF]

Applied and Environmental Microbiology, 2005
ABSTRACT A method was developed for the heterologous expression of biosynthetic gene clusters in different Streptomyces strains and for the modification of these clusters by single or multiple gene replacements or gene deletions with unprecedented speed and versatility.
Alessandra S, Eustáquio, Bertolt, Gust, Ute, Galm, Shu-Ming, Li, Keith F, Chater, Lutz, Heide   +5 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Characterization of the diastaphenazine/izumiphenazine C biosynthetic gene cluster from plant endophyte Streptomyces diastaticus W2

Microbial Biotechnology, 2022
Summary Two phenazine compounds, diastaphenazine and izumiphenazine C, with complex structures and promising antitumour activity have been isolated from the plant endophytic actinomycete Streptomyces diastaticus W2.
Junli Dong, Beibei He, Ruinan Wang, Xiuli Zuo, Rui Zhan, Linfang Hu, Yiqing Li, Jing He   +7 more
doaj   +1 more source

Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster

PLoS ONE, 2016
Transformation-associated recombination (TAR) in yeast is a rapid and inexpensive method for cloning and assembly of large DNA fragments, which relies on natural homologous recombination.
O. Bilyk, O. Sekurova, S. Zotchev, A. Luzhetskyy   +3 more
semanticscholar   +1 more source

Evolution and Diversity of Biosynthetic Gene Clusters in Fusarium

Frontiers in Microbiology, 2018
Plant pathogenic fungi in the Fusarium genus cause severe damage to crops, resulting in great financial losses and health hazards. Specialized metabolites synthesized by these fungi are known to play key roles in the infection process, and to provide survival advantages inside and outside the host.
Koen Hoogendoorn, Koen Hoogendoorn, Lena Barra, Cees Waalwijk, Jeroen S. Dickschat, Theo A. J. van der Lee, Marnix H. Medema   +6 more
openaire   +4 more sources

Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes [PDF]

Journal of Natural Products, 2019
Tuberculosis is an infectious disease of global concern. Members of the diazaquinomycin (DAQ) class of natural products have shown potent and selective activity against drug-resistant Mycobacterium tuberculosis. However, poor solubility has prevented further development of this compound class.
Jana Braesel, Jung-Ho Lee, Benoit Arnould, Brian T. Murphy, Alessandra S. Eustáquio   +4 more
openaire   +2 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Rapid metabolic pathway assembly and modification using serine integrase site-specific recombination [PDF]

, 2013
Synthetic biology requires effective methods to assemble DNA parts into devices and to modify these devices once made. Here we demonstrate a convenient rapid procedure for DNA fragment assembly using site-specific recombination by ϕC31 integrase.
Colloms, S.D., Keasling, J.D., Merrick, C.A., Olorunniji, F.J., Osbourn, A., Rosser, S.J., Smith, M.C.M., Stark, W.M.   +7 more
core   +4 more sources