Results 111 to 120 of about 121,897 (203)

Coenzyme Q10 deficiencies: pathways in yeast and humans. [PDF]

, 2018
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant.
Awad, Agape M, Bradley, Michelle C, Clarke, Catherine F, Fernández-Del-Río, Lucía, Nag, Anish, Tsui, Hui S   +5 more
core  

Rational Design of Polyketide Natural Products

Food Technology and Biotechnology, 2005
Compounds of polyketide origin possess a wealth of pharmacological effects, including antibacterial, antifungal, antiparasitic, anticancer and immunosuppressive activities.
Enej Kuščer, Peter Raspor, Hrvoje Petković   +2 more
doaj  

Predicting protein complexes in biosynthetic gene clusters

ABSTRACT Biosynthetic gene clusters (BGCs) are contiguous genomic regions that encode diverse, non-homologous proteins required for the production of specific natural products. Their genetic diversity underlies the structural complexity of these compounds, and their biosynthetic pathways still remain to be clarified in many cases.
Yoshitaka Moriwaki, Taro Shiraishi, Yohei Katsuyama, Kenichi Matsuda, Toyoyuki Ose, Atsushi Minami, Hideaki Oikawa, Tomohisa Kuzuyama, Ryuichiro Ishitani, Tohru Terada   +9 more
openaire   +1 more source

Characterization of the unconventional meroterpenoid gene cluster from Stachybotrys sp. CPCC 401591 for phenylspirodrimanes biosynthesis

Microbial Cell Factories
Background Phenylspirodrimanes (PSDs) are a unique class of meroterpenoids that have been extensively studied due to their diverse biological activities. These metabolites are supposedly biosynthesized through the farnesylation of orsellinate.
Hui Lv, Bailin Song, Lingjin Bu, Wenni He, Lu Wang, Liyan Yu, Tao Zhang   +6 more
doaj   +1 more source

Research progress on plant biosynthetic gene cluster [PDF]

SCIENTIA SINICA Vitae, 2021
ShuangQian SHEN, ChuanSong ZHAN, ChenKun YANG, Jie LUO   +3 more
openaire   +1 more source

Activating cryptic biosynthetic gene clusters via ACTIMOT

Engineering Microbiology
The mainstream strategy of genome mining relies on the homologous activation and heterologous expression of target biosynthetic gene clusters (BGCs). However, the efficiency of the current techniques available for new compound discovery hardly complements these efforts. In a recent publication in Science, Xie et al. reported their breakthrough progress
openaire   +2 more sources

The Biosynthetic Gene Cluster of Boydines in Scedosporium apiospermum. [PDF]

Mycopathologia
Carvalho C, Hérivaux A, Wéry M, Jouhanneau JC, Papon N, Bouchara JP.   +5 more
europepmc   +1 more source

Unraveling the metabolic potential and roles of reductases in the omicsynin biosynthetic gene cluster. [PDF]

Nat Prod Bioprospect
Li Y, Fu J, Sun H, Du Y, Si S, Li Y, Li X, Jiang J, Hong B.   +8 more
europepmc   +1 more source

The terrein biosynthetic gene cluster of Aspergillus terreus: structure, function, regulation, and similar gene clusters. [PDF]

Front Fungal Biol
Németh MZ, Csíkos S, Kovács GM.
europepmc   +1 more source

A novel <i>Streptomyces</i> species producing thiolutin with anti-MRSA activity and insights into its biosynthetic gene cluster. [PDF]

Front Microbiol
Niu X, Wu Y, Yu X, Wu S, Wen Y, Zhang G, Liu G, Zhang W, Jiang K, Yang H, Zhong M, Jiang J, Yu H.   +12 more
europepmc   +1 more source