Results 121 to 130 of about 3,454,458 (298)

A systems approach to model the relationship between aflatoxin gene cluster expression, environmental factors, growth and toxin production by Aspergillus flavus. [PDF]

, 2011
A microarray analysis was used to examine the effect of combinations of water activity (a(w), 0.995-0.90) and temperature (20-42°C) on the activation of aflatoxin biosynthetic genes (30 genes) in Aspergillus flavus grown on a conducive YES (20 g yeast ...
Geisen, Rolf, Markus Schmidt-Heydt, Magan, Naresh, Roberto Parra, Rolf Geisen, Naresh Magan, Schmidt-Heydt, Markus, Abdel-Hadi, Ahmed, Ahmed Abdel-Hadi, Magan, N., Abdel-Hadi, A., Parra, R., Parra-Saldívar, Roberto   +12 more
core   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Evolutionary trajectory of phytoalexin biosynthetic gene clusters in rice

The Plant Journal, 2016
SummaryPlants frequently possess operon‐like gene clusters for specialized metabolism. Cultivated rice, Oryza sativa, produces antimicrobial diterpene phytoalexins represented by phytocassanes and momilactones, and the majority of their biosynthetic genes are clustered on chromosomes 2 and 4, respectively.
Koji, Miyamoto, Masahiro, Fujita, Matthew R, Shenton, Shota, Akashi, Chizu, Sugawara, Arisa, Sakai, Kiyotaka, Horie, Morifumi, Hasegawa, Hiroshi, Kawaide, Wataru, Mitsuhashi, Hideaki, Nojiri, Hisakazu, Yamane, Nori, Kurata, Kazunori, Okada, Tomonobu, Toyomasu   +14 more
openaire   +3 more sources

Overview of the turnerbactin biosynthetic gene cluster.

, 2013
A. Organization of genes involved in turnerbactin biosynthesis. The locations of putative Fur boxes are indicated by asterisks (*). The black triangle indicates the location of NRPS disruption. B. Domain organization of the NRPS modules of TnbF.
Brian Fishman (469711), Amaro E. Trindade-Silva (153934), Andrew W. Han (134007), Margo G. Haygood (134018), Carlos A. G. Soares (262422), Daniel L. Distel (134016), Alison Butler (469712), Moriah Sandy (469710)   +7 more
core   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites

, 2016
An industrial microorganism, Streptomyces avermitilis, which is a producer of anthelmintic macrocyclic lactones, avermectins, has been constructed as a versatile model host for heterologous expression of genes encoding secondary metabolite biosynthesis ...
Kyoko Komatsu (1934425), Junko Hashimoto (1374684), Motoki Takagi (1695631), David E. Cane (1311837), Kazuo Shin-ya (133016), Ikuko Kozone (504412), Hanae Koiwai (1934428), Miho Izumikawa (1491067), Mamoru Komatsu (1934431), Satoshi Omura (44367), Haruo Ikeda (121866), Yuuki Yamada (1934434)   +11 more
core   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria

eLife
Microbial competition for trace metals shapes their communities and interactions with humans and plants. Many bacteria scavenge trace metals with metallophores, small molecules that chelate environmental metal ions.
Zachary L Reitz, Bita Pourmohsenin, Melanie Susman, Emil Thomsen, Daniel Roth, Alison Butler, Nadine Ziemert, Marnix H Medema   +7 more
doaj   +1 more source