Results 111 to 120 of about 3,454,458 (298)

Proposed biosynthetic gene cluster required to synthesize the inhibitory molecule.

, 2018
Proposed biosynthetic gene cluster required to synthesize the inhibitory molecule.
Pushpavathi Reddyvari (6162860), Ralitsa Borisova (6162863), Abbas G. Shilabin (6162866), Bert C. Lampson (6162869), Amber L. Ward (6162857)   +4 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Deduced function of ORFs in the grecocycline biosynthetic gene cluster.

, 2016
Deduced function of ORFs in the grecocycline biosynthetic gene cluster.
Sergey B. Zotchev (562665), Oksana Bilyk (1432951), Olga N. Sekurova (562661), Andriy Luzhetskyy (1432954)   +3 more
core   +1 more source

Identification and heterologous expression of the globomycin biosynthetic gene cluster

, 2023
Globomycin is a cyclic lipodepsipeptide originally isolated from several Streptomyces species which displays strong and selective antibacterial activity against Gram-negative pathogens.
Weber, Tilmann, Sterndorff, Eva Baggesgaard, Martín, Jesús, Ortiz-López, Francisco Javier, Reyes, Fernando, Gren, Tetiana, Jørgensen, Tue S., Jiang, Xinglin, Oves-Costales, Daniel, Román-Hurtado, Fernando, Genilloud, Olga   +10 more
core   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Correlation of Guaiacol Production With Presence and Expression of the Guaiacol Biosynthetic Gene Cluster in Alicyclobacillus Spp

eFood
The whole genome sequences of A. dauci DSM 28700, A. fastidiosus KKP 3000 (guaiacol producers), and A. fastidiosus DSM 17978 (non‐guaiacol producer) were firstly determined. Then, the presence of the guaiacol biosynthetic gene cluster in genome sequences
Rui Cai, Yanhui Li, Qi Wang, Hong Guo, Yuxiang Zhang, Yahong Yuan, Qinglin Sheng, Zhouli Wang, Tianli Yue   +8 more
doaj   +1 more source

Molecular Biodiversity in Fusarium subglutinans and F. temperatum: A Valuable Tool to Distinguish the Two Sister Species and Determine the Beauvericin Chemotype

Journal of Fungi
Fusarium subglutinans and F. temperatum are widely distributed maize pathogens recognized as distinct species with a species-specific chemotype based on patterns of mycotoxins.
Antonia Susca, Alessandra Villani, Miriam Haidukowski, Filomena Epifani, Antonio F. Logrieco, Antonio Moretti   +5 more
doaj   +1 more source