Results 111 to 120 of about 373,234 (333)

Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster

ChemBioChem, 2016
Comparative transcriptional profiling of a ΔbldM mutant of Streptomyces venezuelae with its unmodified progenitor revealed that the expression of a cryptic biosynthetic gene cluster containing both type I and type III polyketide synthase genes is ...
Anyarat Thanapipatsiri, J. Gomez-Escribano, Lijiang Song, M. Bibb, Mahmoud M. Al-Bassam, G. Chandra, A. Thamchaipenet, G. Challis, M. Bibb   +8 more
semanticscholar   +1 more source

Identification and engineering of 32 membered antifungal macrolactone notonesomycins

Microbial Cell Factories, 2020
Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186.
Falicia Goh, Mingzi M. Zhang, Tian Ru Lim, Kia Ngee Low, Choy Eng Nge, Elena Heng, Wan Lin Yeo, Fernanda L. Sirota, Sharon Crasta, Zann Tan, Veronica Ng, Chung Yan Leong, Huibin Zhang, Alexander Lezhava, Swaine L. Chen, Shawn S. Hoon, Frank Eisenhaber, Birgit Eisenhaber, Yoganathan Kanagasundaram, Fong T. Wong, Siew Bee Ng   +20 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The biosynthetic gene cluster and proposed biosynthetic pathway to kasumigamide.

, 2016
(a) ORFs encoded in the putative kasumigamide biosynthetic gene cluster, kasA-I. Double-headed arrows show the location of pDCYN1-2. The ORFs related to PKS-NRPS are highlighted in red. Putative transposases are colored in green.
Yoko Egami (2110489), Yu Nakashima (3121311), Miki Kimura (2110486), Toshiyuki Wakimoto (1452055), Ikuro Abe (1433923)   +4 more
core   +1 more source

Characterization of the diastaphenazine/izumiphenazine C biosynthetic gene cluster from plant endophyte Streptomyces diastaticus W2

Microbial Biotechnology, 2022
Summary Two phenazine compounds, diastaphenazine and izumiphenazine C, with complex structures and promising antitumour activity have been isolated from the plant endophytic actinomycete Streptomyces diastaticus W2.
Junli Dong, Beibei He, Ruinan Wang, Xiuli Zuo, Rui Zhan, Linfang Hu, Yiqing Li, Jing He   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Genetic and functional characterization of the gene cluster directing the biosynthesis of putisolvin I and II in Pseudomonas putida strain PCL1445

, 2008
Pseudomonas putida PCL1445 secretes two cyclic lipopeptides, putisolvin I and putisolvin II, which possess a surface-tension-reducing ability, and are able to inhibit biofilm formation and to break down biofilms of Pseudomonas species including ...
Dubern, J.F., Stiekema, W.J., Coppoolse, E.R., Bloemberg, G.V.   +3 more
core   +1 more source

E. coli Extracellular Matrix: A Tunable Composite With Hierarchical Structure

Advanced Materials, EarlyView.
The complex composite‐like mechanical behavior of E. coli biofilm matrix is the result of a synergic contribution of the rigid curli and swelling pEtN‐cellulose, and emerges from specific ratio and assembly conditions. The interactions between the two fibers govern biofilm hydration and characteristic wrinkling patterns, providing crucial insights for ...
Macarena Siri, Agustín Mangiarotti, Anne Seewald, Nikolai Rosenthal, Shahrouz Amini, Emeline Raguin, Peter Fratzl, Cécile M. Bidan   +7 more
wiley   +1 more source

Nonlinear Biosynthetic Gene Cluster Dose Effect on Penicillin Production by Penicillium chrysogenum [PDF]

, 2010
Industrial penicillin production levels by the filamentous fungus Penicillium chrysogenum increased dramatically by classical strain improvement. High-yielding strains contain multiple copies of the penicillin biosynthetic gene cluster that encodes three
Woszczynska, Marta,, Ebbendorf, Bjorg,, Nijland, Jeroen G., Ebbendorf, Bjorg, Driessen, Arnold J. M., Bjorg Ebbendorf, Rémon Boer, Jeroen G. Nijland, See Profile, Jeroen G Nijland, Arnold J. M. Driessen, Nijland, Jeroen G.,, Bovenberg, Roel A. L., Marta Woszczynska, Roel A. L. Bovenberg, Roel A L Bovenberg, Boer, Rémon,, Driessen, Arnold J.M.,, Bovenberg, Roel A.L.,, Woszczynska, Marta, Boer, Remon   +20 more
core   +1 more source