Results 231 to 240 of about 379,309 (342)

Evolution and diversification of the momilactone biosynthetic gene cluster in the genus Oryza. [PDF]

New Phytol
Priego-Cubero S, Liu Y, Toyomasu T, Gigl M, Hasegawa Y, Nojiri H, Dawid C, Okada K, Becker C.   +8 more
europepmc   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

The distribution and evolution of muscarine and the ibotenic acid biosynthetic gene cluster within the genus <i>Amanita</i> section <i>Amanita</i> revealed by phylogenomics. [PDF]

IMA Fungus
Su YT, He ZM, Yang YZ, Xu F, Lai MM, Yang ZL, Zhang P, Chen ZH.   +7 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Rediscovery of viomellein as an antibacterial compound and identification of its biosynthetic gene cluster in dermatophytes. [PDF]

Appl Environ Microbiol
Ninomiya A, Masuda K, Yamada T, Kuroki M, Ban S, Yaguchi T, Urayama S-i, Hagiwara D.   +7 more
europepmc   +1 more source

Butirosin Biosynthetic Gene Cluster from Bacillus circulans

Butirosin Biosynthetic Gene Cluster from Bacillus circulans
identifier:oai:t2r2.star.titech.ac.jp ...
openaire  

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Identification and heterologous expression of an NRPS biosynthetic gene cluster responsible for the production of the pyrazinones Ichizinone A, B and C. [PDF]

Microb Cell Fact
Oberhäuser P, Myronovskyi M, Stierhof M, Gromyko O, Luzhetskyy A.   +4 more
europepmc   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Uncovering a novel biosynthetic gene cluster for sordarin through genome mining in the fungus Talaromyces adpressus. [PDF]

Bioresour Bioprocess
Xu Q, Ren X, Hu L, Xu Q, Zhang X, Deng M, Ye Y, Zhang Y, Lu Y, Qiao Y.   +9 more
europepmc   +1 more source