Results 241 to 250 of about 3,454,458 (298)

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Evolution, structure and function of the biosynthetic gene cluster of myriocin, a potent inhibitory sphingolipid

Brand A, Rutter B, Herrera M, Perez-Ortiz G, Greco C, Ashley B, Deng H, Hay A, Bedford C, Wenzel M, Mondo S, Konkel Z, Slot J, Farrer R, Campopiano D.   +14 more
europepmc   +1 more source

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source

The distribution and evolution of muscarine and the ibotenic acid biosynthetic gene cluster within the genus <i>Amanita</i> section <i>Amanita</i> revealed by phylogenomics. [PDF]

IMA Fungus
Su YT, He ZM, Yang YZ, Xu F, Lai MM, Yang ZL, Zhang P, Chen ZH.   +7 more
europepmc   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Genome-Based Mining of Carpatamides I-M and Their Candidate Biosynthetic Gene Cluster. [PDF]

Mar Drugs
Shen SM, Xie YC, Tu LR, Wu ME, Wang YM, Song CH, Sun YH, Luo MH.   +7 more
europepmc   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Expanding the genome information on Bacillales for biosynthetic gene cluster discovery. [PDF]

Sci Data
Song L, Nielsen LJD, Xu X, Mohite OS, Nuhamunada M, Xu Z, Murphy R, Bodawatta K, Poulsen M, Abdulla MH, Sonnenschein EC, Weber T, Kovács ÁT.   +12 more
europepmc   +1 more source

Efficient in vitro refactoring and biosynthetic gene cluster amplification for the overproduction and accelerated discovery of anticancer thioamitides

Santos-Aberturas J, Frattaruolo L, Tassinari E, Rejzek M, Fong LKW, Kawicha P, Sangdee A, Grandellis C, Cappello AR, Truman AW.   +9 more
europepmc   +1 more source

Uncovering a novel biosynthetic gene cluster for sordarin through genome mining in the fungus Talaromyces adpressus. [PDF]

Bioresour Bioprocess
Xu Q, Ren X, Hu L, Xu Q, Zhang X, Deng M, Ye Y, Zhang Y, Lu Y, Qiao Y.   +9 more
europepmc   +1 more source