Results 291 to 300 of about 373,234 (333)
Cell Chemical Biology, 2019 Summary The disconnect between the genomic prediction of secondary metabolite biosynthetic potential and the observed laboratory production profile of microorganisms is well-documented.
Katherine D Bauman +2 more
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Antibiotics, 2018 Specialized metabolites are of great interest due to their possible industrial and clinical applications. The increasing number of antimicrobial resistant infectious agents is a major health threat and therefore, the discovery of chemical diversity and ...
Claudia M Vicente +2 more
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Proceedings of the National Academy of Sciences of the United States of America, 2017 Gregory C A Amos +2 more
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Sequence analysis of porothramycin biosynthetic gene cluster [PDF]
Folia Microbiologica, 2014 The biosynthetic gene cluster of porothramycin, a sequence-selective DNA alkylating compound, was identified in the genome of producing strain Streptomyces albus subsp. albus (ATCC 39897) and sequentially characterized. A 39.7 kb long DNA region contains 27 putative genes, 18 of them revealing high similarity with homologous genes from biosynthetic ...
Lucie Najmanová +2 more
exaly +3 more sources
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A gene cluster of the ochratoxin A biosynthetic genes inPenicillium
Mycotoxin Research, 2006A putative ochratoxin A (OTA) biosynthetic gene cluster inP. nordicum has been identified. The first part of the gene cluster is located on a DNA fragment of 10 kb in length and harbours three genes. A gene with high homology to an alkaline serine protease gene (accession number AY557343), which represents the upstream border of the cluster ...
R, Geisen +2 more
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Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi
Mycological Research, 2008Epipolythiodioxopiperazines (ETPs) are toxic secondary metabolites made only by fungi. Recent research efforts have provided insight into the molecular mechanisms of the toxicity of these compounds. The availability of complete genome sequences for many fungi has also facilitated the identification of putative ETP biosynthetic gene clusters. Expression
Ellen M, Fox, Barbara J, Howlett
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Biosynthetic Gene Clusters in Bacteria: A Review
Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, 2022Soil is a nutrient-rich environment that harbors billions of microbial species. The diversity of microbes in an environment varies with the change in edaphic factors. To survive these environmental changes, microbes produce secondary metabolites which are not directly associated with their growth and reproduction. Bacterial genomes possess biosynthetic
Rimsha Dilshad, Nazia Jamil, Rida Batool
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Computational advances in biosynthetic gene cluster discovery and prediction.
Biotechnology AdvancesBiosynthetic gene clusters (BGCs) are groups of clustered genes found in bacteria, fungi, and some plants and animals that are crucial for synthesizing secondary metabolites.
Sisi Zhu +6 more
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Cloning and Sequencing of the Chaetocin Biosynthetic Gene Cluster
ChemBioChem, 2013How a fungus does it: The epidithiodiketopiperazine (ETP) fungal alkaloids, which include gliotoxin, have garnered much attention since their initial isolation. The cloning and sequencing of the biosynthetic gene cluster for another ETP, chaetocin A were used to suggest a route towards dimerization and sulfur incorporation in these molecules.
Thomas, Gerken, Christopher T, Walsh
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