Results 271 to 280 of about 373,234 (333)

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Increasing TET Expression and 5‐Hydroxymethylcytosine Formation by a Carbocyclic 5‐Aza‐2′‐deoxy‐cytidine Antimetabolite

Angewandte Chemie, EarlyView.
The carbocyclic Decitabine analog (cAzadC) incorporates as an antimetabolite weakly into the genome of growing tumor cells, where it triggers a genome‐wide demethylation and a surprisingly strong hydroxymethylation of cytosine, which translates into an efficient in vivo antitumor (AML) effect.
Maike Däther, Elsa Peev, Annika Fröhlich, Binje Vick, Sogol Fatourechi, Gilles Gasparoni, Matthias Heiss, Corinna C. Pleintinger, Emmanuel Asu Bisong, Hans Hurmiz, Davide Guglielminotti, Yasmin V. Gärtner, Tina Aumer, Karsten Spiekermann, Jörn Walter, Irmela Jeremias, Franziska R. Traube, Thomas Carell   +17 more
wiley   +2 more sources

Structure Elucidation, Biosynthetic Gene Cluster Distribution, and Biological Activities of Ketomemicin Analogs in <i>Salinispora</i>. [PDF]

Mar Drugs
Castro-Falcón G, Guillén-Matus DG, Silva EBD, Guo W, Ross A, Sá Magalhães Serafim M, Fernandes THM, Tantillo DJ, O'Donoghue AJ, Jensen PR.   +9 more
europepmc   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Context matters: assessing the impacts of genomic background and ecology on microbial biosynthetic gene cluster evolution. [PDF]

mSystems
Salamzade R, Kalan LR.
europepmc   +1 more source

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

<i>rm</i>Combi-OGAB for the Directed Evolution of a Biosynthetic Gene Cluster toward Productivity Improvement. [PDF]

ACS Synth Biol
Miyamoto N, Hayashi K, Ogata N, Yamada N, Tsuge K.   +4 more
europepmc   +1 more source

Comprehensive mutant chemotyping reveals embedding of a lineage-specific biosynthetic gene cluster in wider plant metabolism. [PDF]

Proc Natl Acad Sci U S A
Qiao X, Houghton A, Reed J, Steuernagel B, Zhang J, Owen C, Leveau A, Orme A, Louveau T, Melton R, Wulff BBH, Osbourn A.   +11 more
europepmc   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Identification of a Biosynthetic Gene Cluster for the Production of the Blue-Green Pigment Xylindein by the Fungus <i>Chlorociboria aeruginascens</i>. [PDF]

J Nat Prod
Guo Y, Navarro-Muñoz J, Rodenbach C, Dwars E, Dieleman C, van den Hout B, Sanders B, Zhou M, Arogunjo A, Cox RJ, Driessen AJM, Collemare J.   +11 more
europepmc   +1 more source