Results 101 to 110 of about 3,203,016 (289)

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria [PDF]

, 2010
peer-reviewedBackground: Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. These peptides have significant, but largely untapped, potential as preservatives and chemotherapeutic agents. Type 1 lantibiotics are
Ross R Paul, Paul D Cotter, Cotter Paul D, O'Sullivan, Orla, Hill, Colin, Colin Hill, Cotter, Paul D., R Paul Ross, Ross, R Paul, Orla O'Sullivan, Marsh Alan J, O'Sullivan Orla, Marsh, Alan J., Hill Colin, Alan J Marsh   +14 more
core   +1 more source

Characterization and regulation of biosynthetic gene clusters in Aspergillus niger [PDF]

, 2020
Fungi produce a broad range of secondary metabolites with various bioactivities that have allowed them to be used as antibiotics and pharmaceutical drugs. The genes encoding secondary metabolites are commonly organized contiguously into biosynthetic gene
Evdokias, Gregory
core   +3 more sources

Protein‐Nanoarchitectures for Low‐Field Intracellular Electro‐Immunomodulation

Advanced Functional Materials, EarlyView.
DHQ‐SDH‐mediated binding of AuNPs drives the formation of interconnected, chain‐like nanoarchitectures with enhanced electrical conductivity. These conductive assemblies undergo macrophage uptake and enable low‐field electrical stimulation, promoting M1‐to‐M2 phenotypic switching with decreased iNOS and increased CD206 expression. Such protein‐mediated
Viktoriya Pakharenko, Djanira Rodrigues Negrão, Tanmay Gupta, Robert Jeng, Otavio Augusto Titton Dias, Maia Jaffer‐Diaz, Dinesh Christendat, Mohini Sain   +7 more
wiley   +1 more source

Gene Modules Co-regulated with Biosynthetic Gene Clusters for Allelopathy between Rice and Barnyardgrass

, 2019
Allelopathy is a central process in crop–weed interactions and is mediated by the release of allelochemicals that result in adverse growth effects on one or the other plant in the interaction.
Sanling Wu, Dongya Wu, Most. Humaira Sultana, Longjiang Fan, Qian-Hao Zhu, Hongyu Chen, Lingfeng Mao, Fangjie Liu, Fei Fu, Lei Jia, Yingying Wang, Jie Qiu, Weidi Wang, Chuyu Ye, Md. Alamin   +14 more
core   +1 more source

The Transcriptional Architecture of Bacterial Biosynthetic Gene Clusters

Journal of Natural Products
Abstract Bacteria produce diverse bioactive metabolites with ecological and pharmaceutical importance. These compounds are synthesized by biosynthetic gene clusters (BGCs), whose expression is tightly regulated. While many studies have examined the factors influencing BGC expression, including transcription factors (TFs) and ...
Ribeiro Monteiro, Silvia, Kerdel, Yasmine, Gathot, Julianne, Rigali, Sébastien   +3 more
openaire   +3 more sources

Activation of an unconventional meroterpenoid gene cluster in Neosartorya glabra leads to the production of new berkeleyacetals

Acta Pharmaceutica Sinica B, 2018
Fungal genomes carry many gene clusters seemingly capable of natural products biosynthesis, yet most clusters remain cryptic or down-regulated. Genome mining revealed an unconventional paraherquonin-like meroterpenoid biosynthetic gene cluster in the ...
Tao Zhang, Jun Wan, Zhajun Zhan, Jian Bai, Bingyu Liu, Youcai Hu   +5 more
doaj   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

In silico Screening Unveil the Great Potential of Ruminal Bacteria Synthesizing Lasso Peptides

Frontiers in Microbiology, 2020
Studies of rumen microbial ecology suggest that the capacity to produce antimicrobial peptides could be a useful trait in species competing for ecological niches in the ruminal ecosystem.
Yasmin Neves Vieira Sabino, Katialaine Corrêa de Araújo, Fábia Giovana do Val de Assis, Sofia Magalhães Moreira, Thaynara da Silva Lopes, Tiago Antônio de Oliveira Mendes, Sharon Ann Huws, Hilário C. Mantovani   +7 more
doaj   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source