Results 81 to 90 of about 3,203,016 (289)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Identification of the Scopularide Biosynthetic Gene Cluster in Scopulariopsis brevicaulis [PDF]

Marine Drugs, 2015
Scopularide A is a promising potent anticancer lipopeptide isolated from a marine derived Scopulariopsis brevicaulis strain. The compound consists of a reduced carbon chain (3-hydroxy-methyldecanoyl) attached to five amino acids (glycine, l-valine, d-leucine, l-alanine, and l-phenylalanine). Using the newly sequenced S. brevicaulis genome we were able
Lukassen, Mie Bech, Saei, Wagma, Sondergaard, Teis Esben, Tamminen, Anu, Kumar, Abhishek, Kempken, Frank, Wiebe, Marilyn G., Sørensen, Jens Laurids   +8 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efficient algorithms for gene cluster detection in prokaryotic genomes [PDF]

, 2005
Schmidt T. Efficient algorithms for gene cluster detection in prokaryotic genomes. Bielefeld (Germany): Bielefeld University; 2005.The research in genomics science rapidly emerged in the last few years, and the availability of completely sequenced ...
Schmidt, Thomas
core  

A genomics based discovery of secondary metabolite biosynthetic gene clusters in Aspergillus ustus.

PLoS ONE, 2015
Secondary metabolites (SMs) produced by Aspergillus have been extensively studied for their crucial roles in human health, medicine and industrial production.
Borui Pi, Dongliang Yu, Fangwei Dai, Xiaoming Song, Congyi Zhu, Hongye Li, Yunsong Yu   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Minimum Information about a Biosynthetic Gene cluster [PDF]

, 2017
A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters.
Geiger, Christoph, Yim, Grace, Düsterhus, Stephanie, Payne, Shelley M, Ploux, Olivier, Viaud, Muriel, Scott, Barry, Petras, Daniel, Kormanec, Jan, Osburne, Marcia S, Liu, Xinyu, Wright, Gerard D, de Bruijn, Irene, Aigle, Bertrand, Lautru, Sylvie, Katz, Leonard, Melnik, Alexey V, Cummings, Matthew, Monroe, Emily A, Gomez-Escribano, Juan Pablo, Haines, Anthony S, Gross, Harald, Wilkinson, Barrie, Gerwick, William H, Keller, Nancy P, Kottmann, Renzo, Brakhage, Axel A, Fewer, David P, Gerwick, Lena, Moore, Marcus, Caffrey, Patrick, Lee, Chia Y, Truman, Andrew W, Yu, Fengan, Sherman, David, Tahlan, Kapil, Wiemann, Philipp, Sivonen, Kaarina, Stegmann, Evi, Donadio, Stefano, Tang, Yi, Rui, Zhe, Mast, Yvonne, Greule, Anja, Nett, Markus, Kötter, Peter, Bode, Helge B, Hertweck, Christian, Linquan, Bai, Smanski, Michael J, Brady, Sean F, Weber, Tilmann, Yilmaz, Pelin, Blin, Kai, Cox, Russell J, Metsä-Ketelä, Mikko, Jones, Carla S, Mahmud, Taifo, Helfrich, Eric J N, Zhang, Changsheng, Höfte, Monica, Kwon, Hyung-Jin, Masschelein, Joleen, Jensen, Susan E, Cruz-Morales, Pablo, Mantovani, Simone M, Reen, F Jerry, Petricek, Miroslav, Entian, Karl-Dieter, Süssmuth, Roderich D, Clardy, Jon, Jones, Adam C, Claesen, Jan, Kyrpides, Nikos C, Ju, Jianhua, Wyckoff, Elizabeth, Micklefield, Jason, Dorrestein, Pieter C, Takano, Eriko, Hillwig, Matthew L, Rosconi, Federico, Borriss, Rainer, Donia, Mohamed S, Moss, Nathan, Jungmann, Katrin, Kuzuyama, Tomohisa, Wohlleben, Wolfgang, Krug, Daniel, Glöckner, Frank Oliver, Gust, Bertolt, Apel, Alexander K, Zotchev, Sergey B, O, Fergal, van Wezel, Gilles P, Tsunematsu, Yuta, Walton, Jonathan D, Ehling-Schulz, Monika, Kuipers, Oscar P, Edwards, Daniel J, Yan, Xiaohui, Duddela, Srikanth, Driessen, Arnold J M, Méndez, Carmen, Sosio, Margherita, Osbourn, Anne, Chooi, Yit Heng, Kim, Hyun Uk, Salas, José A, Kegler, Carsten, Medema, Marnix H, Ostash, Bohdan, Coates, R Cameron, Lavigne, Rob, Walsh, Christopher, Balibar, Carl J, Doyle, Sean, Mitchell, Douglas A, Liu, Wen, Garg, Neha, Tian, Zhenhua, Müller, Rolf, Breitling, Rainer, Ishida, Keishi, Neilan, Brett A, Moore, Bradley S, Raaijmakers, Jos M, Nützmann, Hans-Wilhelm, Nielsen, Jens, Cheng, Yi-Qiang, Pan, Guohui, De Mot, René, Seipke, Ryan F, Barona-Gómez, Francisco, Kaysser, Leonard, Xie, Yunchang, Moreira, Leonilde M, Thomas, Christopher M, Oikawa, Hideaki, van der Donk, Wilfred A, Piel, Jörn, Willey, Joanne M, Fischbach, Michael A, Shen, Ben, Biggins, John B, Ziemert, Nadine, Luzhetskyy, Andriy, Schmitt, Esther K, Pati, Amrita, Pernodet, Jean-Luc, Tobias, Nicholas J, Klassen, Jonathan L, Balskus, Emily, Hadjithomas, Michalis, Bechthold, Andreas   +153 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

BMC Genomics, 2020
Background Lanthipeptides belong to the ribosomally synthesized and post-translationally modified peptide group of natural products and have a variety of biological activities ranging from antibiotics to antinociceptives.
Mark C. Walker, Sara M. Eslami, Kenton J. Hetrick, Sarah E. Ackenhusen, Douglas A. Mitchell, Wilfred A. van der Donk   +5 more
doaj   +1 more source