Results 71 to 80 of about 62,800 (259)

A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene cluster (MIBiG) repository: prospects for research-based educational experiences

Standards in Genomic Sciences, 2018
Microorganisms utilize complex enzymatic pathways to biosynthesize structurally complex and pharmacologically relevant molecules. These pathways are encoded by gene clusters and are found in a diverse set of organisms.
Samuel C. Epstein, Louise K. Charkoudian, Marnix H. Medema   +2 more
doaj   +1 more source

Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica [PDF]

Tetrahedron, 2014
The lomaiviticins are a family of cytotoxic marine natural products that have captured the attention of both synthetic and biological chemists due to their intricate molecular scaffolds and potent biological activities. Here we describe the identification of the gene cluster responsible for lomaiviticin biosynthesis in Salinispora pacifica strains DPJ ...
Jeffrey E, Janso, Brad A, Haltli, Alessandra S, Eustáquio, Kerry, Kulowski, Abraham J, Waldman, Li, Zha, Hitomi, Nakamura, Valerie S, Bernan, Haiyin, He, Guy T, Carter, Frank E, Koehn, Emily P, Balskus   +11 more
openaire   +2 more sources

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Microbiological and molecular insights on rare Actinobacteria harboring bioactive prospective

Bulletin of the National Research Centre, 2020
Background Actinobacteria is as a group of advanced filamentous bacteria. Rare Actinobacteria are of special interest as they are rarely isolated from the environments. They are a major source of important bioactive compounds.
Dina H. Amin, Nagwa A. Abdallah, Assem Abolmaaty, Sahar Tolba, Elizabeth M. H. Wellington   +4 more
doaj   +1 more source

The Transcriptional Architecture of Bacterial Biosynthetic Gene Clusters

Journal of Natural Products
Abstract Bacteria produce diverse bioactive metabolites with ecological and pharmaceutical importance. These compounds are synthesized by biosynthetic gene clusters (BGCs), whose expression is tightly regulated. While many studies have examined the factors influencing BGC expression, including transcription factors (TFs) and ...
Ribeiro Monteiro, Silvia, Kerdel, Yasmine, Gathot, Julianne, Rigali, Sébastien   +3 more
openaire   +3 more sources

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source

Activation of an unconventional meroterpenoid gene cluster in Neosartorya glabra leads to the production of new berkeleyacetals

Acta Pharmaceutica Sinica B, 2018
Fungal genomes carry many gene clusters seemingly capable of natural products biosynthesis, yet most clusters remain cryptic or down-regulated. Genome mining revealed an unconventional paraherquonin-like meroterpenoid biosynthetic gene cluster in the ...
Tao Zhang, Jun Wan, Zhajun Zhan, Jian Bai, Bingyu Liu, Youcai Hu   +5 more
doaj   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

In silico Screening Unveil the Great Potential of Ruminal Bacteria Synthesizing Lasso Peptides

Frontiers in Microbiology, 2020
Studies of rumen microbial ecology suggest that the capacity to produce antimicrobial peptides could be a useful trait in species competing for ecological niches in the ruminal ecosystem.
Yasmin Neves Vieira Sabino, Katialaine Corrêa de Araújo, Fábia Giovana do Val de Assis, Sofia Magalhães Moreira, Thaynara da Silva Lopes, Tiago Antônio de Oliveira Mendes, Sharon Ann Huws, Hilário C. Mantovani   +7 more
doaj   +1 more source