Results 51 to 60 of about 3,203,016 (289)
Journal of Fungi, 2023 Genomic analysis has demonstrated that many fungi possess essential gene clusters for the production of previously unobserved secondary metabolites; however, these genes are normally reduced or silenced under most conditions.
Mengyao Xue +8 more
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Genome Mining for Actinomycete Biosynthetic Gene Clusters [PDF]
, 2018 Whole-genome sequencing has shown that the large (8-12 Mbp) genomes of Streptomyces and allied genera of Gram-positive filamentous bacteria house a rich and previously underestimated repertoire of gene clusters for biosynthesis of specialised metabolites,
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ML-Miner: A Machine Learning Tool Used for Identification of Novel Biosynthetic Gene Clusters
, 2022 Identifying biosynthetic gene clusters from genomic data is challenging, with many in-silico tools suffering from a high rediscovery rate due to their dependence on rule-based algorithms.
Wambo, Paul A.
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Identification and analysis of the resorcinomycin biosynthetic gene cluster [PDF]
Bioscience, Biotechnology, and Biochemistry, 2015 Abstract Resorcinomycin (1) is composed of a nonproteinogenic amino acid, (S)-2-(3,5-dihydroxy-4-isopropylphenyl)-2-guanidinoacetic acid (2), and glycine. A biosynthetic gene cluster was identified in a genome database of Streptoverticillium roseoverticillatum by searching for orthologs of the genes responsible for biosynthesis of ...
Koichi, Ooya +3 more
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BMC Genomics, 2023 Exploring Brevibacterium strains from various ecosystems may lead to the discovery of new antibiotic-producing strains. Brevibacterium sp. H-BE7, a strain isolated from marine sediments from Northern Patagonia, Chile, had its genome sequenced to study ...
Andrés Cumsille +8 more
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mSphere of Influence: Systematically Decoding Microbial Chemical Communication
mSphere, 2019 Laura A. Mike works in the field of bacterial pathogenesis. In this mSphere of Influence article, she reflects on how “Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters” by P. Cimermancic et al. (Cell 158:
Laura A. Mike
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Cloning and characterization of the biosynthetic gene cluster for kutznerides [PDF]
Proceedings of the National Academy of Sciences, 2007 Kutznerides, actinomycete-derived cyclic depsipetides, consist of six nonproteinogenic residues, including a highly oxygenated tricyclic hexahydropyrroloindole, a chlorinated piperazic acid, 2-(1-methylcyclopropyl)-glycine, a β-branched-hydroxy acid, and 3-hydroxy glutamic acid, for which biosynthetic logic has not been elucidated.
Danica Galonic, Fujimori +5 more
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Microbial Biotechnology, 2021 Summary Butenyl‐spinosyn, a promising biopesticide produced by Saccharopolyspora pogona, exhibits stronger insecticidal activity and a broader pesticidal spectrum. However, its titre in the wild‐type S.
Jie Rang +14 more
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Plant genome mining for triterpene biosynthetic genes and gene clusters [PDF]
, 2020 Plant specialised metabolites are highly diverse in their functions and chemistries. The discovery of plant biosynthetic gene clusters (BGCs) and the rapidly increasing volume of sequence data available for analysis provides a timely opportunity for wide,
Owen, Charlotte
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The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum
Journal of Industrial Microbiology & Biotechnology, 2004 The erythromycin-biosynthetic (ery) gene cluster of Aeromicrobium erythreum was cloned and characterized. The 55.4-kb cluster contains 25 ery genes. Homologues were found for each gene in the previously characterized ery gene cluster from Saccharopolyspora erythraea. In addition, four new predicted ery genes were identified.
Igor A, Brikun +4 more
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