Results 61 to 70 of about 3,203,016 (289)
Biosynthetic gene clusters and the evolution of fungal chemodiversity
Natural Product Reports, 2020 This highlight synthesizes knowledge of the molecular evolutionary processes – functional divergence, horizontal transfer, and de novo assembly – that govern biosynthetic gene cluster diversification and the generation of chemodiversity in fungi.
Antonis Rokas +4 more
openaire +3 more sources
Chromatin-level regulation of biosynthetic gene clusters [PDF]
Nature Chemical Biology, 2009 Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B.
Jin Woo, Bok +11 more
openaire +2 more sources
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. [PDF]
Proceedings of the National Academy of Sciences, 1995 The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesis of clinically valuable analogues.
Schwecke, Torsten +12 more
openaire +2 more sources
ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequences. [PDF]
PLoS ONE, 2012 Thiopeptides are a growing class of sulfur-rich, highly modified heterocyclic peptides that are mainly active against Gram-positive bacteria including various drug-resistant pathogens.
Jing Li +8 more
doaj +1 more source
Transcriptional regulation of the novobiocin biosynthetic gene cluster [PDF]
Microbiology, 2009 The aminocoumarin antibiotic novobiocin is a gyrase inhibitor formed by a Streptomyces strain. The biosynthetic gene cluster of novobiocin spans 23.4 kb and contains 20 coding sequences, among them the two regulatory genes novE and novG. We investigated the location of transcriptional promoters within this cluster by insertion of transcriptional ...
Dangel, Volker +6 more
openaire +3 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Genomic and chemical analyses of 713 marine biofilm-derived bacterial strains
Applied and Environmental MicrobiologyMarine biofilms are known as a reservoir of bacterial specialized metabolites, but the majority of these metabolites remain unexplored because most biofilm-associated bacteria have not yet been cultivated or genomically characterized.
Jie Lu +6 more
doaj +1 more source
Marine Drugs, 2018 Mycemycins A–E are new members of the dibenzoxazepinone (DBP) family, derived from the gntR gene-disrupted deep sea strain Streptomyces olivaceus FXJ8.012Δ1741 and the soil strain Streptomyces sp. FXJ1.235.
Fangying Song +4 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Predicted secondary metabolite biosynthetic gene clusters in 30 streptomycetes genome
, 2020 Genomic positions and putative products of predicted secondary metabolite biosynthetic gene clusters in 30 streptomycetes ...
Namil Lee (1909531) +6 more
core +1 more source